Sensitivity of laser opto-acoustic imaging in detection of small deeply embedded tumors

Esenaliev, Rinat O.; Karabutov, Alexander A.; Oraevsky, Alexander A.

doi:10.1109/2944.796320

Cited by 230 publications

(177 citation statements)

References 27 publications

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“…PAI is a promising non-ionizing and noninvasive biomedical imaging technique based on the photoacoustic effect 6 with simultaneous sensitive optical contrast and high ultrasonic resolution. This imaging technique has been applied for detecting early cancers 6,8,9 and monitoring thermal lesions generated by HIFU or other means. 10,11 In this study, we report an enhanced-heating effect during PAI-guided HIFU therapy.…”

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confidence: 99%

Enhanced-heating effect during photoacoustic imaging-guided high-intensity focused ultrasound

Cui¹,

Yang²

2011

Applied Physics Letters

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Photoacoustic imaging (PAI) technique has been used to monitor thermal lesion formation during high-intensity focused ultrasound (HIFU) treatment. While previous studies focused on photoacoustic detection of changes in temperature during HIFU treatment, we report an enhanced-heating effect when PAI is used to monitor HIFU treatment. We found that the temperature induced by HIFU could be significantly enhanced when the diagnostic laser system for photoacoustic detection was operating during HIFU treatment. This finding demonstrates an advantage of using PAI to guide HIFU therapy.

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confidence: 99%

Enhanced-heating effect during photoacoustic imaging-guided high-intensity focused ultrasound

Cui¹,

Yang²

2011

Applied Physics Letters

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“…Moreover, they used only 16 receive elements to form an image using a diagnostic frequency ultrasound array. Others [17][18][19][20] have also demonstrated the use of arrays for photoacoustic imaging, however for low diagnostic frequencies. Optical detection of ultrasound using Fabry-Perot etalons has led to emerging 2-D arrays, recently producing 3-D microvascular images in animals and human subjects [21].…”

Section: Introductionmentioning

confidence: 99%

Realtime photoacoustic microscopy in vivo with a 30-MHz ultrasound array transducer

Zemp¹,

Liu²,

Bitton³

et al. 2008

Opt. Express

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Abstract:We present a novel high-frequency photoacoustic microscopy system capable of imaging the microvasculature of living subjects in realtime to depths of a few mm. The system consists of a high-repetitionrate Q-switched pump laser, a tunable dye laser, a 30-MHz linear ultrasound array transducer, a multichannel high-frequency data acquisition system, and a shared-RAM multi-core-processor computer. Data acquisition, beamforming, scan conversion, and display are implemented in realtime at 50 frames per second. Clearly resolvable images of 6-μm-diameter carbon fibers are experimentally demonstrated at 80 μm separation distances. Realtime imaging performance is demonstrated on phantoms and in vivo with absorbing structures identified to depths of 2.5-3 mm. This work represents the first high-frequency realtime photoacoustic imaging system to our knowledge.

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“…The feasibility of imaging small, deeply embedded tumors was also studied by Esenaliev et al, who used tissue phantoms. 9 Oraevsky et al used photoacoustic imaging to detect ductal-lobular carcinoma in the human breast. 10 Using a single ultrasonic transducer to scan circularly about a small-animal head, Wang et al 11,12 and Ku et al 13 reconstructed clear photoacoustic images of the cortical vasculature in the brain in vivo with high spatial resolution and high optical contrast.…”

Section: Introductionmentioning

confidence: 99%

Imaging of tumor angiogenesis in rat brains in vivo by photoacoustic tomography

Ku¹,

Wang²,

Xie³

et al. 2005

Appl. Opt.

216

137

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Green laser pulses at a wavelength of 532 nm from a Q-switched Nd:YAG laser were employed as irradiation sources for photoacoustic tomography (PAT). The vascular structure of the brain was imaged clearly, with optimal contrast, because blood has strong absorption near this wavelength. The photoacoustic images of rat brain tumors in this study clearly reveal the angiogenesis that is associated with tumors. Brain tumors can be identified based on the distorted vascular architecture of brain tumorigenesis and related vascular changes, such as hemorrhage. This research demonstrates that PAT can potentially provide a powerful tool for small-animal biological research.

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Sensitivity of laser opto-acoustic imaging in detection of small deeply embedded tumors

Cited by 230 publications

References 27 publications

Enhanced-heating effect during photoacoustic imaging-guided high-intensity focused ultrasound

Enhanced-heating effect during photoacoustic imaging-guided high-intensity focused ultrasound

Realtime photoacoustic microscopy in vivo with a 30-MHz ultrasound array transducer

Imaging of tumor angiogenesis in rat brains in vivo by photoacoustic tomography

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