Sensitivity of periodontal-pathological microflora and Candida fungi to dual probiotic

Mirsaeva, Faniya; Ханов, Тимур; Кузнецова, Т. Н.

doi:10.33925/1683-3759-2019-24-4-323-327

Cited by 4 publications

(2 citation statements)

References 3 publications

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“…В связи с этим восстановление баланса между микробным пейзажем и местным иммунитетом полости рта относится к важным условиям терапии воспалительных заболеваний пародонта. Современные пробиотики, которые в настоящее время применяются в современной стоматологической и гастроэнтерологической практике, решают широкий круг задач [10]:…”

Section: Introductionunclassified

“…По результатам выполненных исследований и результатам работ ряда авторов[10] можно сделать вывод о ведущей роли дефицита INF-γ в развитии хронического пародонтита. Низкое содержание в ЗДЖ и ПК INF-γ способствует угнетению фагоцитарной активности макрофагов, что в свою очередь обеспечивает защитный эффект для клеток Candida, предотвращая их поглощение фагоцитами, тем самым давая им возможность выживать при незавершенном фагоцитозе.…”

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The role of probiotics in correction of microbiocenosis and cytokine balance of the oral cavity of patient with chronic inflammatory disease of periodont

et al. 2020

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Relevance. A long-term inflammation in the oral cavity, unreasonable treatment of periodontal patients with antibiotics cause imbalance between certain types of fungal-bacterial associations accompanied by oral dysbiosis and change of local immune status. So, development and application of new comprehensive diagnosis and treatment techniques in periodontal patients, use of products for correction of microbiota and local immunity are a current and a long-term task. Purpose is to optimize the comprehensive treatment protocol of inflammatory periodontal diseases by introducing probiotics and evaluation of oral microbiome and cytokine profile.Materials and methods. 140 patients were examined. Of these 60 patients had chronic generalized plaque-induced gingivitis and 60 patients suffered from moderate chronic generalized periodontitis. Bacterial and fungal microbiome was assessed and the host immune response was evaluated in all patients before and after the treatment. Half of the patients were treated conventionally and the other half were treated according to a modified scheme: probiotic “Bifidumbacterin Forte” was added.Results. A large number of yeast-like fungi Candida and commensal bacteria were detected in periodontal pockets of patients with chronic generalized plaque-induced gingivitis and moderate chronic generalized periodontitis. That correlates with a significant increase of pro-inflammatory cytokines (TNF-α, IL—8), decrease of concentration of INF-γ and increase of antiinflammatory cytokine IL-4.Conclusion. Changes in clinical, microbiological and immunological values during a modified combination therapy with a probiotic and during a conventional treatment demonstrated that effectiveness of treatment of chronic gingivitis and chronic periodontitis increased by 40% and 37% respectively.

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The role of probiotics in correction of microbiocenosis and cytokine balance of the oral cavity of patient with chronic inflammatory disease of periodont

et al. 2020

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Effectiveness of treatment of patients with chronic catarrhal gingivitis working in limestone mining

Haibullina

Rahmatullina

Valeeva

et al. 2021

Russian Journal of Dentistry

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BACKGROUND: Inflammatory periodontal diseases are an important medical and social problem, since more than 90% of the adult population of the Russian Federation suffer from this pathology. AIM: The work is to study the effectiveness of the treatment of chronic catarrhal gingivitis in employees of a limestone mining enterprise based on clinical and microbiological methods. MATERIALS AND METHODS: We examined 214 employees aged 2227 years (machinists, crushers, sorters and workers of the administrative and economic part) working at a limestone mining enterprise (Ufa). Chronic catarrhal gingivitis was detected in 61 patients. To determine the effectiveness of treatment by randomization, patients were divided into the 1st (main) group (n=31) with chronic catarrhal gingivitis, who were prescribed the treatment recommended by us, and the 2nd (comparison) group (n=30) with chronic catarrhal gingivitis, who were treated with basic therapy. Clinical studies were conducted according to the standard scheme and recorded in the medical history. anamnesis was collected, dental formula, plaque, swelling and hyperemia of the gums were registered during the dental examination, bite and occlusive contacts were evaluated. The following indices were used: hygienic, bleeding, papillary-marginal-alveolar (PMA). RESULTS: Clinical and functional data of these patients were obtained. A microbiological assessment of the gingival fluid content is given. Issues of the diagnostics and treatment of patients with chronic gingivitis (catarrhal) with the use of a drug based on lactobacilli and bifidobacteria and Placentol are considered. The effectiveness of the treatment has been determined. CONCLUSION: The proposed method using resorption of Smart candies and rinsing with Placentol balm in patients with chronic catarrhal gingivitis working at a limestone mining enterprise is more effective and can be included in the protocol for the treatment of patients with chronic catarrhal gingivitis working at limestone mining.

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Probiotics – a new panacea for periodontal diseases?! Literature review

Taimazova,

Choniashvili,

Avanisyan

et al. 2023

Medicinskij alfavit

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Introduction. The emergence of new antibiotic-resistant strains of microorganisms, the widespread spread of viral and fungal diseases, as well as the growing allergisation of the population have generated interest in bacterial preparations – probiotics, which include living microorganisms – representatives, as a rule, of the obligate human microflora, which, when ingested in sufficient quantities, enter the body, retain their activity and viability, have a positive effect on the patient’s health.The purpose of the study was to review the literature on this topic, to determine the concepts of the use of probiotics in dentistry, as well as to identify promising directions in the development of methods of therapy of periodontal diseases with their use.Materials and methods. When studying this issue, scientific sources indexed in the Higher Attestation Commission, Scopus and Web of Sciences were analyzed.Results. Probiotics are a recognized therapeutic adjunct for various generalized and systemic diseases of the oral cavity. Their role in the prevention and treatment of dental caries, as well as its complications, is a direction that has been studied quite fully in the last two decades. The evidence for this is reflected in many randomized control studies. To test various probiotic combinations, it is necessary to conduct multicenter studies so that patients can take advantage of the entire therapeutic spectrum of new drugs based on probiotics and synbiotics.

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Sensitivity of periodontal-pathological microflora and Candida fungi to dual probiotic

Cited by 4 publications

References 3 publications

The role of probiotics in correction of microbiocenosis and cytokine balance of the oral cavity of patient with chronic inflammatory disease of periodont

The role of probiotics in correction of microbiocenosis and cytokine balance of the oral cavity of patient with chronic inflammatory disease of periodont

Effectiveness of treatment of patients with chronic catarrhal gingivitis working in limestone mining

Probiotics – a new panacea for periodontal diseases?! Literature review

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