Sensitivity-related illness: The escalating pandemic of allergy, food intolerance and chemical sensitivity

Genuis, Stephen J.

doi:10.1016/j.scitotenv.2010.08.047

Cited by 83 publications

(101 citation statements)

References 162 publications

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“…Certain food antigens and specific IgG antibodies may form immune complexes that could cause an inflammatory cascade. 23 Similarly, high levels of the IgG4 food antibodies are also observed in patients with inflammatory bowel disease, where intestinal mucosal permeability is known to be increased. 24,25 Some studies have demonstrated that food-specific IgG4 antibody-guided exclusion diet may be effective in alleviating IBS symptoms.…”

Section: Discussionmentioning

confidence: 98%

Alterations of Food-specific Serum IgG4 Titers to Common Food Antigens in Patients With Irritable Bowel Syndrome

Lee

2017

J Neurogastroenterol Motil

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Background/AimsThe role of dietary factors in the pathogenesis of irritable bowel syndrome (IBS) is still unclear. The aim of this study was to compare IgG4 levels to common food antigens between patients with IBS and healthy controls. MethodsThirty-two patients diagnosed as IBS according to the Rome III criteria (12 diarrhea subgroup; 20 non-diarrhea subgroup) and 32 sex and age-matched healthy controls participated in the study. Serum IgG4 titers to 90 common foods were measured in each subject. The number of subjects with positivity defined as the cut-off value ≥ 0.7 U/mL was compared. ResultsPatients with IBS had significantly higher IgG4 titers to wheat, leek and taro compared to those of controls. Serum IgG4 titers to ginger, cocoa, walnut, white radish, onion, and lettuce in IBS patients tended to be higher than controls. IgG4 titers to wheat, gluten and gliadin in the diarrhea subgroup, and lettuce, leek and taro in the non-diarrhea subgroup tended to be higher compared with controls. The number of subjects with positivity to apple, orange, lettuce, and leek was significantly higher in IBS patients than controls. The number of subjects with positivity to apple, orange, gluten, and gliadin in the diarrhea subgroup, and egg white, pineapple, soybean, lettuce, and leek in the non-diarrhea subgroup was significantly higher compared with controls. ConclusionsSerum IgG4 antibody levels to some common foods are abnormally elevated in IBS patients. The type of foods with abnormally elevated serum IgG4 titers in the diarrhea subgroup may be different from that in the non-diarrhea subgroup. (J Neurogastroenterol Motil 2017;23:578-584)

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Section: Discussionmentioning

confidence: 98%

Alterations of Food-specific Serum IgG4 Titers to Common Food Antigens in Patients With Irritable Bowel Syndrome

Lee

2017

J Neurogastroenterol Motil

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“…A pathophysiological hypothesis has been proposed for MCS. Exogenous toxic exposures cause toxicant-induced loss of tolerance with dysregulation of immune state (5), which may involve N-methyl-D-aspartate (NMDA) sensitization with increased level of nitric oxide (NO) and peroxynitrite (5). No medication has been found to be effective for the treatment of MCS (3).…”

Section: Introductionmentioning

confidence: 99%

Levetiracetam improves symptoms of multiple chemical sensitivity: Case report

et al. 2017

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: Multiple chemical sensitivity (MCS) is a disorder of unknown etiology with no effective treatment. Many clinicians accept that a diagnosis of somatic symptoms disorder (SSD) is an appropriate diagnostic category for MCS. We found that administration of levetiracetam improved recurrent symptoms of MCS in a patient. A 23-year-old female presented with recurrent multiple symptoms of musculoskeletal, airway or mucous membrane, heart/chest-related, gastrointestinal, cognitive, affective, neuromuscular, head-related, and skinrelated induced by exposure to diesel or gas engine exhaust, tobacco smoke, insecticide, gasoline, paint or paint thinner, cleaning products, fragrances, tar or asphalt, nail polish or hairspray, and new furnishings. Gastrointestinal, cognitive, and skin-related symptoms were precipitated by some food additives. She suffered partial seizures from the age of 17 years, and was diagnosed with right parietal lobe epilepsy. Administration of levetiracetam (250 mg/day) eliminated her MCS symptoms. Levetiracetam reduces the release of presynaptic neurotransmitter including glutamate by binding to presynaptic vesicle protein. A recent study established the presence of glutamatergic overactivation in somatization disorder, a form of SSD. Our case may indicate that a subset of patients with SSD have glutamatergic overactivation, which levetiracetam can normalize.

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“…It appears that fetal vitamin D levels may play a modulating role in immune functions involved in atopic disorders. As hypersensitivity outcomes may also be seen in those children born to mothers contaminated with assorted xenobiotics in pregnancy [207,208], however, it is not known whether the immune dysregulation and hypersensitivity may be the consequence of a primary gestational insufficiency of vitamin D, or whether various chemical toxicants might play a role by impairing vitamin D uptake, renal synthesis, and assimilation [209] while at the same time inducing immune compromise and hypersensitivity through other mechanisms [210].…”

Section: • Intrauterine Growthmentioning

confidence: 99%

Vitamin D and Human Reproduction

Tehrani¹,

Behboudi‐Gandevani²

2017

A Critical Evaluation of Vitamin D - Basic Overview

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Vitamin D is one of the steroid hormones. The precursor of vitamin D, 7-dehydrocholesterol, which is an intermediary for cholesterol pathway, is available in the skin. Ultraviolet B (UVB) radiation makes the transformation of 7-dehydrocholesterol to provitamin D3, which automatically isomerizes to cholecalciferol (vitamin D3). Vitamin D3 is secreted into blood circulation and carried by the vitamin D-binding protein (VDBP). Around 80-90% of vitamin D is from sunlight-derived production in the skin. A little amount of vitamin D is also extracted from foods and/or additional supplementation. Vitamin D has been well known for its function in maintaining calcium and phosphorus homeostasis and promoting bone mineralization. Accumulating evidence from animal and human studies suggests that vitamin D also modulates reproductive processes in women and men and is involved in many functions of the reproductive system. Vitamin D receptor (VDR) and vitamin D-metabolizing enzymes are found in reproductive tissues of women and men. This chapter presents an up-to-date review for describing the function of vitamin D in female reproduction throughout reproductive ages from menarche to menopause, during pregnancy and lactation, and some disorders affecting women and also the role of vitamin D applied to male fertility.

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Sensitivity-related illness: The escalating pandemic of allergy, food intolerance and chemical sensitivity

Cited by 83 publications

References 162 publications

Alterations of Food-specific Serum IgG4 Titers to Common Food Antigens in Patients With Irritable Bowel Syndrome

Alterations of Food-specific Serum IgG4 Titers to Common Food Antigens in Patients With Irritable Bowel Syndrome

Levetiracetam improves symptoms of multiple chemical sensitivity: Case report

Vitamin D and Human Reproduction

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