Sensitivity to ageing of the limbic dopaminergic system: a review

Barili, Paolo; Carolis, Gionni De; Zaccheo, D; Amenta, Francesco

doi:10.1016/s0047-6374(98)00104-3

Cited by 57 publications

(28 citation statements)

References 208 publications

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“…Changes like loss of dendritic arborisation, neuronal death, and neurofibrillary abnormalities are found to occur in the cerebral cortex of aging individuals, including areas which are involved in nociceptive processing, like the prefrontal cortex, primary and secondary somatosensory cortex, anterior cingulate, hippocampus, thalamus, and insula [13]. The turnover and concentration of catecholamines [56] GABA [57] and opioid receptors [58] within the limbic system are found to be decreased, as well as serotonin receptor density [59], mainly within the prefrontal cortex and anterior cingulate [60].…”

Section: Physiological Changes With Agingmentioning

confidence: 99%

Effect of Age, Sex and Gender on Pain Sensitivity: A Narrative Review

Eltumi¹,

Tashani²

2017

TOPAINJ

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Introduction:An increasing body of literature on sex and gender differences in pain sensitivity has been accumulated in recent years. There is also evidence from epidemiological research that painful conditions are more prevalent in older people. The aim of this narrative review is to critically appraise the relevant literature investigating the presence of age and sex differences in clinical and experimental pain conditions. Methods:A scoping search of the literature identifying relevant peer reviewed articles was conducted on May 2016. Information and evidence from the key articles were narratively described and data was quantitatively synthesised to identify gaps of knowledge in the research literature concerning age and sex differences in pain responses. Results:This critical appraisal of the literature suggests that the results of the experimental and clinical studies regarding age and sex differences in pain contain some contradictions as far as age differences in pain are concerned. While data from the clinical studies are more consistent and seem to point towards the fact that chronic pain prevalence increases in the elderly findings from the experimental studies on the other hand were inconsistent, with pain threshold increasing with age in some studies and decreasing with age in others. Conclusion:There is a need for further research using the latest advanced quantitative sensory testing protocols to measure the function of small nerve fibres that are involved in nociception and pain sensitivity across the human life span. Implications:Findings from these studies should feed into and inform evidence emerging from other types of studies (e.g. brain imaging technique and psychometrics) suggesting that pain in the older humans may have unique characteristics that affect how old patients respond to intervention.

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Section: Physiological Changes With Agingmentioning

confidence: 99%

Effect of Age, Sex and Gender on Pain Sensitivity: A Narrative Review

Eltumi¹,

Tashani²

2017

TOPAINJ

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“…12 In elderly people a remarkable decrease in dopamine and HVA has been observed. 39 It has been hypothesized that the incidence of dopamine-subtype depression, existing in a group of depressed elderly, may be due to an increased monoamine-oxidase B activity, responsible for dopamine specific metabolism. 40 As indicated above, depressive symptoms such as apathy and diminished self-initiated planning are characteristic of Parkinson's patients, however we are still facing an unresolved question.…”

Section: The Role Of Noradrenaline and Serotoninmentioning

confidence: 99%

Extrapyramidal symptoms and antidepressant drugs: neuropharmacological aspects of a frequent interaction in the elderly

et al. 2001

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Depression is the most prevalent functional psychiatric disorder in late life. The problem of motor disorders associated with antidepressant use is relevant in the elderly. Elderly people are physically more frail and more likely to be suffering from physical illness, and any drug given may exacerbate pre-existing diseases, or interact with other drug treatments being administered for physical conditions. Antidepressants have been reported to induce extrapyramidal symptoms, including parkinsonism. These observations prompted us to review the neurobiological mechanism that may be involved in this complex interplay including neurotransmitters and neuronal circuits involved in movement and emotion control and their changes related to aging and disease. The study of the correlations between motor and mood disorders and their putative biochemical bases, as presented in this review, provide a rationale either to understand or to foresee motor side effects for psychotropic drugs, in particular antidepressants. Molecular Psychiatry (2001) 6, 134-142.

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“…The DA limbic system, as well the blood oxygenation level-dependent signal measured by fMRI, are sensitive to aging. [19][20][21] Therefore, to avoid a possible aging confound, we decided to study a healthy population in the same age range as typical PD patients.…”

mentioning

confidence: 99%