Sensitization from ketotifen fumarate in eye drops presenting as chronic conjunctivitis

Smets, Kyra; Werbrouck, Justine; Goossens, An; Gilissen, Liesbeth

doi:10.1111/cod.12695

Cited by 19 publications

(3 citation statements)

References 12 publications

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“…Eyelid symptoms have been reported as the most common location in previous studies, being a part of the periorbital region 1,4 . Interestingly, solitary conjunctivitis was observed in four patients, which has also previously been described 11 …”

Section: Discussionsupporting

confidence: 75%

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Topical eye medications causing allergic contact dermatitis

et al. 2022

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Background: Allergic contact dermatitis (ACD) in the eye region caused by topical eye medications is difficult to diagnose and may be overlooked.Objective: To study the characteristics and causative agents in patients with ACD caused by topical eye medications in a Danish tertiary dermatology department.Methods: A retrospective study of 318 patients, patch tested between 2013 and 2021 due to suspected ACD to topical eye medications. All patients were tested with a locally developed eye medication series, some were additionally tested with suspected eye medications. Medical records were studied in patch test positive patients.Results: Contact allergy to a topical eye allergen/medication was found in 12.9% (n = 41) of 318 patients, and culprit allergens were phenylephrine (6.9%), timolol (2.5%) and ketotifen (1.6%). Patch test positive patients were often previously diagnosed with cataract (29.3%) or glaucoma (24.4%), and the majority reported more than one previous reaction. Initial symptoms were oedema (56.0%), erythema (48.8%) and dermatitis (31.7%) in the eye region, and facial dermatitis was also seen. Conclusions:Patients with symptoms from the eye region who have been using topical eye medications should be patch tested with ingredients from commonly used eye medications supplemented by the products tested 'as is'.

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Section: Discussionsupporting

confidence: 75%

“…1,4 Interestingly, solitary conjunctivitis was observed in four patients, which has also previously been described. 11 Almost half of the patients reported symptoms for 1 year or more. The reason for the delay between symptoms and diagnosis may be that symptoms can resemble other skin conditions.…”

Section: Discussionmentioning

confidence: 99%

Topical eye medications causing allergic contact dermatitis

et al. 2022

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“…Allergic contact dermatitis (ACD) caused by topical ophthalmic medications, which is often overlooked in eye diseases, is most often characterized by eczematous lesions involving the eyelids or periorbital skin, whereas conjunctivitis only rarely occurs . In order to identify the most common culprits, the results of patch tests performed in our tertiary referral patch test clinic between 1990 and 2016 were retrospectively analysed, with a focus on both the active principles and non‐active components (excipients) of topical ophthalmic medications.…”

Section: Introductionmentioning

confidence: 99%

Allergic contact dermatitis caused by topical ophthalmic medications: Keep an eye on it!

et al. 2019

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Background Allergic contact dermatitis (ACD) caused by topical ophthalmic medications is often overlooked. Objectives To study the demographic characteristics, lesion locations and associated medical conditions of the patients with ACD caused by ophthalmic drugs, and to identify the most common allergenic culprits, as well as trends in frequencies over the years. Methods From January 1990 until December 2016, 16 065 patients were investigated in our clinic; all patients with a positive patch test reaction to an eye medication or its ingredient(s) having caused ACD were assessed. For each allergen identified, the number of positive test results as compared with the total number of those in the total population, as well as trends across three periods, namely 1990 to 1998, 1999 to 2007, and 2008 to 2016, were studied. Results One hundred and eighteen patients (0.7%) presented with positive patch test reactions to ingredients of and/or topical ophthalmic medications. Aminoglycoside antibiotics, followed by corticosteroids, as pharmacologically active ingredients, as well as wool alcohols, thiomersal, and benzalkonium chloride, as excipients, were the most frequent culprits. Chloramphenicol showed a decreasing trend of positive reactions over time, whereas reactions to tobramycin increased. Conclusion ACD caused by eye medication is mainly attributable to active principles, but other excipient ingredients, beside the products “as is,” should be tested as well.

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Contact Allergy to Topical Drugs

Goossens¹,

Gonçalo²

2020

Contact Dermatitis

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Sensitization from ketotifen fumarate in eye drops presenting as chronic conjunctivitis

Cited by 19 publications

References 12 publications

Topical eye medications causing allergic contact dermatitis

Topical eye medications causing allergic contact dermatitis

Allergic contact dermatitis caused by topical ophthalmic medications: Keep an eye on it!

Contact Allergy to Topical Drugs

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