Sensitization to bovine serum albumin as a possible cause of allergic reactions to vaccines

Silva, Rajiva de; Dasanayake, W.M.D.K.; Wickramasinhe, G.D.; Karunatilake, Chandima; Weerasinghe, Nayani; Gunasekera, Peshala; Malavige, Gathsaurie Neelika

doi:10.1016/j.vaccine.2017.02.009

Cited by 33 publications

(34 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Data on the aetiology of anaphylaxis from South Asian countries is not available. The demographics or aetiology of anaphylaxis in Sri Lanka has not been systematically studied with the only available data being the aetiology of anaphylaxis due to specific triggers such as food dependent exercise induced anaphylaxis (FDEIA) and anaphylaxis to vaccines [ 9 , 10 ]. Since the prevalence of allergy related diseases are reported to be on the rise in many countries including Sri Lanka [ 11 ], the study of causes of anaphylaxis in South Asian countries such as Sri Lanka is necessary.…”

Section: Introductionmentioning

confidence: 99%

Aetiology of anaphylaxis in patients referred to an immunology clinic in Colombo, Sri Lanka

Silva

Dasanayake

Karunatilake

et al. 2018

Allergy Asthma Clin Immunol

Self Cite

View full text Add to dashboard Cite

BackgroundThe aetiology of anaphylaxis differs according to types of foods consumed, fauna and foliage and cultural practices. Although the aetiology of anaphylaxis in Western countries are well known, the causes in South Asian countries have not been reported. We sought to determine the causes of anaphylaxis in patients referred to an immunology clinic in Colombo, Sri Lanka.Methods238 episodes of anaphylaxis were reviewed in 188 patients who were referred and skin prick tests and in vitro tests (ImmunoCap) were carried out to assess the presence of allergen specific IgE. Clinical features and severity of anaphylaxis was also recorded along with treatment received.ResultsAnaphylaxis to food either following direct exposure 90/238 (37.5%) or after exercise in the form of food dependent exercise induced anaphylaxis 29/238 (12.2%) was the predominant cause of anaphylaxis. Allergy to cow’s milk and red meat, after immediate exposure, accounted for 66/238 (27.7%) of instances of all episodes of anaphylaxis and 66/90 (73.33%) of anaphylaxis due to food. Vaccines accounted for 28/238 (11.8%) of instances of anaphylaxis, especially among children. Of those who developed anaphylaxis to the MMR (n = 14), 71.4% of them had specific IgE to cow’s milk and 35.7% of them had specific IgE to beef. Of those who developed anaphylaxis to insect stings, 27/42 of these episodes occurred following stings of ants (family Formicidae). The predominant cause of anaphylaxis changed with the age, with food allergy being the most frequent trigger of anaphylaxis in childhood, while drug allergy and idiopathic anaphylaxis being more frequent after 30 years of age.ConclusionsIn this cohort, anaphylaxis to red meat appears to be the predominant cause of food induced anaphylaxis and presence of beef specific IgE and cow’s milk, appears to be a predisposing factor for vaccine induced anaphylaxis.

show abstract

Section: Introductionmentioning

confidence: 99%

Aetiology of anaphylaxis in patients referred to an immunology clinic in Colombo, Sri Lanka

Silva

Dasanayake

Karunatilake

et al. 2018

Allergy Asthma Clin Immunol

Self Cite

View full text Add to dashboard Cite

show abstract

“…In a study conducted by the Department of Immunology, Medical Research Institute, vaccine allergy accounted for 11.8% of instances of anaphylaxis [18]. In this study, 238 episodes of anaphylaxis, in 188 patients who attended the clinic from 2012 to 2017, were assessed.…”

Section: Vaccine Allergy In Sri Lankamentioning

confidence: 99%

“…Other vaccines implicated were DT, DPT, Hepatitis A/B and the pentavalent vaccine. The majority of vaccine allergic patients were sensitised to either mammalian meat or cows' milk [18].…”

Section: Vaccine Allergy In Sri Lankamentioning

confidence: 99%

Evidence update on vaccine allergy

Dasanayake

Silva

2019

J. Postgrad. Inst. Med.

View full text Add to dashboard Cite

“…Анало-гичные данные получены при определении специ-фических IgE к аллергену яйца -овомукоиду [39]. Описано выявление специфических IgE к белкам ко-ровьего молока, бычьему сывороточному альбумину [40] и казеину [41], имеющим значение в развитии ана-филаксии при вакцинации. Во всех перечисленных случаях для определения специфических IgE исполь-зовалась тест-система ImmunoCAP.…”

Section: идентификация возможного причинно-значимого агентаunclassified

Anaphylaxis and Vaccination: Risks and Realities

Петровна¹,

Николаевич²

2018

Ross. vestn. perinatol. pediatr.

View full text Add to dashboard Cite

The article is about the problem of anaphylaxis in the post-vaccination period. Data on the frequency of its prevalence and lethality depending on the type of vaccine are presented. Variants of a clinical picture of anaphylaxis and differential-diagnostic approaches are indicated. The major causal components of vaccines, anaphylaxis inducers, and methods for their identification are mentioned. Therapeutic approaches are analyzed, false myths and contraindications to vaccination are indicated. The experience of carrying out preventive individual measures is generalized.

show abstract

Sensitization to bovine serum albumin as a possible cause of allergic reactions to vaccines

Cited by 33 publications

References 23 publications

Aetiology of anaphylaxis in patients referred to an immunology clinic in Colombo, Sri Lanka

Aetiology of anaphylaxis in patients referred to an immunology clinic in Colombo, Sri Lanka

Evidence update on vaccine allergy

Anaphylaxis and Vaccination: Risks and Realities

Contact Info

Product

Resources

About