Sensitization to fragrances in Spain: A 5‐year multicentre study (2011‐2015)

Silvestre, Juan Francisco; Mercader, Patricia; González‐Pérez, R.; Hervella‐Garcés, Marcos; Sanz‐Sánchez, T.; Córdoba, Susana; Sánchez‐Pérez, Javier; Heras-Mendoza, Felipe; Giménez‐Arnau, Ana; Gática‐Ortega, María Elena; Pastor‐Nieto, María‐Antonia; Zaragoza, V.; Carrascosa, J.M.; García-Bravo, Begoñá; Ruíz‐González, Inmaculada; Borrego, Leopoldo; Sánchez‐Pedreño, Paloma; Frutos, J. Ortiz De; Hita, J. C. Armario; García‐Gavín, J.; Fernández‐Redondo, Virginia

doi:10.1111/cod.13152

Cited by 21 publications

(25 citation statements)

References 29 publications

(93 reference statements)

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“…It has to be emphasized that the patch test baseline series should also be tested when suspected "sun-exposed dermatitis" is investigated, because (photoaggravated) allergic contact dermatitis, for example, to isothiazolinones can mimic photoallergic contact dermatitis, as shown in our patients and as previously described in the literature. [21][22][23][24][25][26][27][28] In conclusion, our results are in accordance with those published for the consensus photopatch test series. They confirm the usefulness of the European photopatch test baseline series.…”

Section: Resultssupporting

confidence: 91%

European photopatch test baseline series: A 3‐year experience

et al. 2018

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Section: Resultssupporting

confidence: 91%

European photopatch test baseline series: A 3‐year experience

et al. 2018

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“…Regarding cosmetic allergens, the reduced prevalences of fragrance mix I allergy and fragrance mix II allergy have most probably resulted from the replacement of those fragrances with the numerous alternatives that are now available for use in cosmetics that do not have to be labelled. 20,21 Thus, fragrance mixes I and II might no longer be sufficient for screening for fragrance contact allergy in patients, and new substances may need to be added to baseline series. Conversely, the prevalence of Myroxylon pereirae resin allergy did not significantly change in the current study period.…”

Section: Resultsmentioning

confidence: 99%

Changing trends of contact allergens in Thailand: A 12‐year retrospective study

et al. 2019

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Background: Contact allergen prevalences often change. Continual surveillance is necessary to detect trends in sensitization rates and emerging allergens.Objective: To identify the prevalence of, and trends in, the positive reactions to each allergen in the baseline series during a 12-year period in Thailand. Methods: The medical records of 2803 patients who underwent patch testing at the Contact Dermatitis Clinic, Siriraj Hospital, between 2006 and 2018, were retrospectively reviewed. The baseline series used by the clinic was adapted from the European and the International baseline series. The patch testing results were subdivided into 2-year blocks in order to compare the prevalences of each allergen. Results: The prevalences of positive reactions to nickel, fragrance mixes I and II, dichromate, cobalt, carba mix, methyldibromo glutaronitrile, paraben mix, neomycin sulfate, methylisothiazolinone (MI), epoxy resin, N-isopropyl-N-phenyl-4-phenylenediamine and the corticosteroids significantly decreased. Methylchloroisothiazolinone (MCI)/MI was the only allergen associated with a significant increase of positive reactions, from 2.4% to 10.7%. However, the proportion of positive reactions to MCI/MI decreased in the final 2-year period. Conclusions: Approximately half of the substances in the screening patch test series showed a decline in the number of positive reactions, whereas MCI/MI showed an increasing prevalence. Atopic family history, n (%) 985 (35.1) History of metal allergy, n (%) 1087 (38.8) History of cosmetic allergy, n (%) 397 (14.2) History of drug allergy, n (%) 488 (17.4) Positive for at least one allergen, n (%) 1850 (66.0) Of these: clinical relevance, n (%) 1226 (66.3) SUKAKUL ET AL. 125

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“…5,46,47 In Spain, positivity rates were 2.4%, 6.4%, and 5.8%. 31,48,49 In Sweden, 4.8% to 6.5% of routine patients reacted to MP. 27,30,50 Other European countries have also presented their patch test results with MP: The Netherlands, 2.8% (the low frequency probably resulting from the use of TRUE Test); Finland, 6.2%; Belgium, 6.1%; Switzerland, 7.8%; and the Czech Republic, 7.3%.…”

Section: General Populationmentioning

confidence: 99%

“…29,30 In almost all studies, MP allergy occurred significantly more often in the older (>40 years) age groups. 26,27,[29][30][31] In a large Information Network of Departments of Dermatology (IVDK) study, risk quantified by the prevalence ratio rose with increasing age vs reference (age T A B L E 1 Ingredients identified in Myroxylon pereirae resin (MP), extracts, and essential oils (adapted from Ref. 5 1-36 years) from 1.87 (age 37-50 years) and 2.79 (age 51-64 years) to 3.32 (age 65-99 years).…”

mentioning

confidence: 99%

Myroxylon pereiraeresin (balsam of Peru) – A critical review of the literature and assessment of the significance of positive patch test reactions and the usefulness of restrictive diets

Groot¹

2019

Contact Dermatitis

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In this article, contact allergy to Myroxylon pereirae resin (MP) (balsam of Peru) is reviewed. The topics presented include the uses, the chemical composition, the frequency of sensitization, the relevance of positive reactions, the MP-containing products causing allergic contact dermatitis, co-reactivity with other fragrance and nonfragrance materials, the sensitizers, the usefulness of MP as a "marker" of fragrance allergy, and the effectiveness of, and indications for, "balsam-restrictive" diets. Sensitization to MP occurs in 4% to 8% of patients routinely tested for suspected contact dermatitis. There are few adequate data on relevance. Topical pharmaceuticals were formerly, but are not today, important sources of sensitization. Cosmetics and foods or drinks are hardly ever products responsible for sensitization to MP. Positive patch test reactions in the large majority probably result from previous sensitization to MP constituents because of their presence in fragrances and fragranced products, MP thereby acting as marker (or "indicator") of fragrance allergy. However, fragrance mix I is a more sensitive marker, and the added diagnostic value of testing with MP is unknown. The allergenic ingredients of MP include isoeugenol, eugenol and cinnamyl alcohol, but there are other-largely unknown-chemicals that are responsible for contact allergy. Suggestions are given for further research to address questions thus far unanswered and to improve patient care. K E Y W O R D Sbalsam of Peru, balsam-restrictive diet, chemical composition, eugenol, cinnamyl alcohol, coniferyl benzoate, fragrance, isoeugenol, Myroxylon pereirae resin, perfume, fragrance marker, contact allergy

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Sensitization to fragrances in Spain: A 5‐year multicentre study (2011‐2015)

Cited by 21 publications

References 29 publications

European photopatch test baseline series: A 3‐year experience

European photopatch test baseline series: A 3‐year experience

Changing trends of contact allergens in Thailand: A 12‐year retrospective study

Myroxylon pereiraeresin (balsam of Peru) – A critical review of the literature and assessment of the significance of positive patch test reactions and the usefulness of restrictive diets

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