Sensitization to Laboratory
Animals and
Small-Airway Hyperreactivity

Willers, Stefan; Hjortsberg, Ufl; Ja, Wihl; Ørboek, Palle

doi:10.1159/000463416

Cited by 3 publications

(12 citation statements)

References 13 publications

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“…We have also found that sensitisation to animals is associated with small airway hyperreactivity [28], In another follow-up study of 38 workers, the animal-sensitised subjects showed significantly increased airway reactivity com pared to non-sensitised subjects [34].…”

Section: Clinical Picture and Allergy Work-upmentioning

confidence: 78%

“…There ap pears to be an immunological difference between LAA analysis and the gene locus has been assigned to chromo some 1 lq [54]. We have found that atopy indicators such as parental and childhood allergy, raised total serum IgE level and positive skin prick tests against environmental allergens increase the risk of developing LAA [8,28,31], Through the use of these indicators of atopy, LAA asthma could be predicted with 50% sensitivity and 100% specificity in the last study. This was in contrast to LAA rhinitis where the indicators were unable to discriminate symptom cases from symptom-free subjects.…”

Section: Incidence Of Laamentioning

confidence: 82%

“…Various modes of genetic transmission have been pro posed, but no generally recognised model has been estab lished. Family studies have demonstrated that atopy is under genetic control but the hereditary mechanism is unclear [44,45], A maternal history of allergic disease has been reported to be more common than paternal [46], In two studies, we found that family history of allergy was associated with LAA [8,28], Several studies have shown an elevated risk of developing LAA, especially asthma, in individuals with atopy. The occurrence of three concepts of atopy (see definitions) and their rela tion to LAA symptoms is shown in table 4.…”

Section: Incidence Of Laamentioning

confidence: 83%

“…Dual attacks of bronchial obstruction have been de scribed after inhalation of urine extracts from rats and mice [24], A positive skin prick test against offending animal(s) in subjects with symptoms from animal contact will confirm the aetiology. A high correlation between positive skin prick test reaction and specific IgE RAST has been reported [10,17,[25][26][27], However, skin prick testing has been reported to be more sensitive than RAST [15,28]. Symptomatic subjects will often also react with positive skin prick tests to animals other than symptom-provoking animal species in the laboratory [3], Late cutaneous responses to skin prick testing have also been reported in LAA subjects [3,11,28].…”

Section: Definitionsmentioning

confidence: 99%

“…A high correlation between positive skin prick test reaction and specific IgE RAST has been reported [10,17,[25][26][27], However, skin prick testing has been reported to be more sensitive than RAST [15,28]. Symptomatic subjects will often also react with positive skin prick tests to animals other than symptom-provoking animal species in the laboratory [3], Late cutaneous responses to skin prick testing have also been reported in LAA subjects [3,11,28]. An involvement ofIgE-dependent reactions was proposed by Dolovich et al [29] although the mechanism was later shown to be an extra cellular deposition of eosinophil and neutrophil granule proteins [30],…”

Section: Definitionsmentioning

confidence: 99%

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Laboratory Animal Allergy - A Review

Sjöstedt¹,

Willers²,

Ørbæk³

1995

Indoor Built Environ

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Animal allergen exposure is a significant risk factor for allergy in animal workers. Laboratory animal allergy has a prevalence of 11-44% in those who work with animals. This review gives information on the clinical picture, medical examination and prophylactic strategies for monitoring both the environment and the individual. Background data concerning epidemiology, predisposing factors, allergic mechanisms and exposure to various animal allergens are also given.

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Section: Clinical Picture and Allergy Work-upmentioning

confidence: 78%

Section: Incidence Of Laamentioning

confidence: 82%

Section: Incidence Of Laamentioning

confidence: 83%

Section: Definitionsmentioning

confidence: 99%

Section: Definitionsmentioning

confidence: 99%

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Laboratory Animal Allergy - A Review

Sjöstedt¹,

Willers²,

Ørbæk³

1995

Indoor Built Environ

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A follow‐up study of laboratory animal exposed workers: The influence of atopy for the development of occupational asthma

Sjöstedt¹,

Willers

Ørbæk

1993

American J Industrial Med

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In a 5-year follow-up study of 88 animal exposed laboratory technicians, the incidence of laboratory animal allergy (LAA), lung function, and the development of allergy test reactivity were investigated. Only two individuals developed test positive LAA rhinitis during the follow-up period. Furthermore, one subject who had previously had LAA rhinitis developed LAA asthma. In the remaining subjects the results of skin prick tests against laboratory animals and environmental allergens, total serum IgE levels, and lung function were unchanged. Atopy defined as parental and childhood allergy, raised total serum IgE levels, and positive skin prick tests against nonanimal environmental allergens and nonlaboratory animals (dog and horse) were risk indicators for development of test positive LAA asthma. The low incidence of LAA during the 5-year follow-up is interpreted as a result of an early LAA development in atopic subjects.

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Categories of Adverse Health Effects from Indoor Air Pollution

Weetman¹,

Munby²

1994

Indoor Built Environ

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There is a lack of precision in the definition of health, which leads to confusion in the assessment of adverse effects arising from indoor air pollution. Adverse health effects range from annoyance to life-threatening conditions. Survey responses suggest that males and females differ in their perception of a healthy person, but both sexes envisage a male in terms of positive fitness, strength, energy and the possession of an athletic body, rather than how long one was likely to live. Psychological fitness was relatively unimportant in describing the health of others, but was rated as very important with respect to one’s own health. Mortality statistics tend to obscure the proportion of the population who suffer chronic illness that is not life threatening. Although health is largely determined by genetic constitution, lifestyle and environmental factors, the morale of an individual is also important. A new classification of the adverse effects on health of indoor air pollution is proposed: this includes ‘comfort’ responses, such as sick building syndrome (category 1); acute biological effects, including allergies and microbiological infections (category 2A); acute chemical effects, the nature of which depends upon the specific intoxicant (category 2B), and perceived chronic grave risk, including cancer causation (category 3). The magnitude of risk in this latter category is imprecise, because its measurement involves the technique of quantitative risk assessment.

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Sensitization to Laboratory Animals and Small-Airway Hyperreactivity

Cited by 3 publications

References 13 publications

Laboratory Animal Allergy - A Review

Laboratory Animal Allergy - A Review

A follow‐up study of laboratory animal exposed workers: The influence of atopy for the development of occupational asthma

Categories of Adverse Health Effects from Indoor Air Pollution

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