Sensitization to Lepidoglyphus destructor, Tyrophagus putrescentiae, and Acarus siro in patients allergic to house dust mites (Dermatophagoides spp.)

Vidal, Carmen; Chomon, B.; Perez‐Carral, Celsa; González‐Quintela, Arturo

doi:10.1016/s0091-6749(97)70181-7

Cited by 30 publications

(30 citation statements)

References 8 publications

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“…Several studies have reported limited or inexistent cross-reactivity between storage mites and mites of the genus Dermatophagoides (Vidal et al, 1997). Our results show a significant correlation between house dust mites and storage mites.…”

Section: Discussionsupporting

confidence: 63%

“…In Galicia, storage mites are frequently found in house dust. One study reported that 71% of house dust samples contained storage mites, mainly L. destructor (Vidal et al, 1997), while another detected low concentrations of L. destructor allergen in almost all homes studied Acta Veterinaria Hungarica 56, 2008 and high concentrations of T. putrescentiae allergen in all homes studied (Boquete et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

“…As Vidal et al (1997) note, in order to adapt the composition of immunotherapy, we need to elucidate whether the frequency of sensitisation to storage mites is due to cross-reactions with house dust mites or to multiple sensitisations. Several studies have reported limited or inexistent cross-reactivity between storage mites and mites of the genus Dermatophagoides (Vidal et al, 1997).…”

Section: Discussionmentioning

confidence: 99%

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Importance of house dust and storage mites in canine atopic dermatitis in the geographic region of Galicia, Spain

Goicoa

Espino

Rodriguez

et al. 2008

Acta Veterinaria Hungarica

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Sensitisation to mites is frequent in atopic dogs. The main mite genus involved in canine atopic dermatitis is Dermatophagoides. The importance of storage mite allergens in dogs has been controversial. The aim of this study was to evaluate the sensitisation rates against storage mites (Lepidoglyphus destructor and Tyrophagus putrescentiae) and house dust mites (Dermatophagoides farinae and D. pteronyssinus) in atopic dogs from Galicia, a highly humid and temperate region of Spain, using a FcεRIα-based immunoglobulin E (IgE) in vitro test. The study was performed on 95 dogs suffering from atopic dermatitis and presenting detectable specific serum IgE levels: 91.6% of the dogs tested positive for storage mites, whereas sensitisation to house dust mites was detected in 87.4%. These results indicate the importance of storage mites in this specific geographic area.

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Section: Discussionsupporting

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Importance of house dust and storage mites in canine atopic dermatitis in the geographic region of Galicia, Spain

Goicoa

Espino

Rodriguez

et al. 2008

Acta Veterinaria Hungarica

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“…17 The preferred habitat of these mites is stored food. 17 Although storage mites have been shown to be important allergens, both in farmers and in urban populations, [17][18][19][20] this was not the case in our patients. This may also be due to the low humidity.…”

Section: Discussionmentioning

confidence: 53%

“…Most investigations have found a positive association between storage mites and house-dust mite sensitisation, while other studies have found no association. 1,17,[19][20][21] The rate of sensitisation to storage mites in house-dust mite-allergic patients has been reported to be 60 -90%, [19][20][21][22] but it is uncertain whether this is a result of cosensitisation or of cross-reacting antibodies. 18 This study was not designed to determine which of these possibilities is most likely.…”

Section: Discussionmentioning

confidence: 99%

Mite and cockroach sensitisation in patients with allergic rhinitis in the Free State

Seedat

Claassen

et al. 2010

S Afr Med J

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Clinical Trial With a Depigmented, Polymerized Mite Mixture Extract at Maximum Concentrations

Vidal,

Romero,

Lopez‐Freire

et al. 2024

Immunity Inflam & Disease

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BackgroundEfficacy of allergen immunotherapy is dose‐dependent; however, high doses of allergen may imply a greater risk of adverse reactions.ObjectiveTo assess the safety and tolerability of subcutaneous immunotherapy (SCIT) with mixtures of mite allergen extracts, Dermatophagoides pteronyssinus/Blomia tropicalis (Dpt/Bt) and Dermatophagoides pteronyssinus/Lepidoglyphus destructor (Dpt/Ld) at maximum concentrations, in adult patients with allergic rhinitis or rhinoconjunctivitis, and controlled allergic asthma due to a clinically relevant sensitisation to these mites.MethodsAn open‐label, noncontrolled, nonrandomised, phase IIb clinical trial was carried out in three hospitals in Spain between September 2014 and May 2018. Patients received SCIT of either Dpt/Bt (100/1000 DPP/mL) or Dpt/Ld (100/100 DPP/mL) in two phases: a rush build‐up phase on the first day (0.2 mL and 0.3 mL with a 30‐min interval) and a monthly maintenance phase administration (0.5 mL) up to 48 months.ResultsForty patients were recruited for the study, seven allocated to the Dpt/Bt group and 33 to the Dpt/Ld. None experienced immediate or delayed systemic Grade ≥ 2 reactions (EAACI classification) (systemic reactions were mostly Grade 1) nor died during the study. Local reactions were mostly mild (0‒10 cm). Thirty‐nine patients (97.5%) experienced at least one adverse event (AE). Of the 283 reported AEs, eight (2.8%) were systemic reactions experienced by six (15%) subjects and 14 (4.9%) were local reactions sustained by ten (25%) subjects.ConclusionsSCIT treatment of patients with allergic rhinitis or rhinoconjunctivitis and controlled asthma with mixtures of Dpt/Bt and Dpt/Ld allergen extracts at maximum concentrations showed a favourable safety profile.

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Sensitization to Lepidoglyphus destructor, Tyrophagus putrescentiae, and Acarus siro in patients allergic to house dust mites (Dermatophagoides spp.)

Cited by 30 publications

References 8 publications

Importance of house dust and storage mites in canine atopic dermatitis in the geographic region of Galicia, Spain

Importance of house dust and storage mites in canine atopic dermatitis in the geographic region of Galicia, Spain

Mite and cockroach sensitisation in patients with allergic rhinitis in the Free State

Clinical Trial With a Depigmented, Polymerized Mite Mixture Extract at Maximum Concentrations

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