Sensor arrays based on nanoparticles for early detection of kidney injury by breath samples

Nakhleh, Morad K.; Amal, Haitham; Awad, Hoda; Gharra, Alaa; Abu-Saleh, Niroz; Jeries, Raneen; Haick, Hossam; Abassi, Zaid

doi:10.1016/j.nano.2014.06.007

Cited by 37 publications

(31 citation statements)

References 55 publications

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“…[6][7][8][9][10][11][12][13][14]. Nature and concentration of VOC in the breath extract of healthy subjects differ from that of patients suffering from above mentioned diseases and these differences can to be smelled out by an electronic nose [15][16][17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Spray layer-by-layer assembly of POSS functionalized CNT quantum chemo-resistive sensors with tuneable selectivity and ppm resolution to VOC biomarkers

Nag

Sachan

Castro

et al. 2016

Sensors and Actuators B: Chemical

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Section: Introductionmentioning

confidence: 99%

Spray layer-by-layer assembly of POSS functionalized CNT quantum chemo-resistive sensors with tuneable selectivity and ppm resolution to VOC biomarkers

Nag

Sachan

Castro

et al. 2016

Sensors and Actuators B: Chemical

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“…Summary of the current data on disease detection using breath analysis as a function of the different capping ligand used with the gold nanoparticles. (C) Reproduced with permission from Elsevier from [42] . (D) Reproduced with permission from the European Respiratory Society.…”

Section: Nephrology Systemmentioning

confidence: 99%

“…Using these responses, the classification accuracy score was 92%. A second classifier was able to distinctly classify acute kidney inquiry samples according to the severity of the kidney failure with 86% accuracy [42]. These are very important results, especially due to the fact that early intervention and treatment of acute kidney injury is crucial for patient prognosis [48].…”

Section: Nephrology Systemmentioning

confidence: 99%

Monolayer-Capped Gold Nanoparticles for Disease Detection From Breath

Nakhleh

Broza

Haick

2014

Nanomedicine (Lond.)

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The recognition of volatile organic compounds in breath samples is a promising approach for noninvasive safe diagnosis of disease. Spectrometry and spectroscopy methods used for breath analysis suffer from suboptimal accuracy, are expensive and are unsuitable for diagnostics. This article presents a concise review on arrays of monolayer-capped gold nanoparticle (GNP) sensors in conjugation with pattern recognition methods for cost-effective, fast and high-throughput point-of-care diagnostic results from exhaled breath samples. The article starts with a general introduction to the rationale and advantages of breath analysis as well as with a presentation of the utility of monolayer-capped GNP sensors in this field. The article continues with a presentation of the main fabrication and operation principles of these GNP sensors and concludes with selected examples regarding their utility in different fields of medicine, particularly in neurology, infectiology, respiratory medicine and oncology.

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“…In comparison with GC or GC-MS based breath analysis, breath sensors have the advantages of portability, cost-effectiveness, easy operation, fast reading, and the potential for chemical fingerprinting when an array of sensors is coupled with pattern recognition. Recent studies of nanoparticle-based chemiresistor arrays have shown potentials for detecting cancers, diabetes, and other diseases [12][13][14][15][16][17][18][19][20][21][22][23][24]. For detecting lung cancer [14,[20][21][22], most of the routine techniques are often invasive, expensive and slow, and require complex instruments and pre-concentration of biomarkers [14,20].…”

Section: Introductionmentioning

confidence: 99%

“…To achieve the desired sensitivity and selectivity to the VOCs, it is essential to use different sensing array materials. There have been examples of nanoparticles [12][13][14][16][17][18][19]23], polymers [15] and carbon blacks [15,20]. The coupling of sensor arrays with the pattern recognition methods is also essential for the breath recognition between healthy people and lung cancer patients.…”

Section: Introductionmentioning

confidence: 99%

Detection of mixed volatile organic compounds and lung cancer breaths using chemiresistor arrays with crosslinked nanoparticle thin films

Zhao

Al-Nasser

Shan

et al. 2016

Sensors and Actuators B: Chemical

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The ability to create sensing thin films for chemiresistors using crosslinked nanoparticle thin films with subtle structural differences in terms of interparticle linker molecular structure, nanoparticle composition and size is important not only for tuning sensitivity and selectivity in constructing a sensor array but also for enhancing stability of the sensors under ambient sensing conditions. In this report, we show that arrays of chemiresistors with such subtle structural differences are viable for detecting mixed volatile organic compounds (VOCs) and breath biomarkers under ambient conditions. The sensor arrays exhibit nanostructure-tunable sensitivity to VOCs and mixtures, with a limit of detection as low as 20-ppb easily achievable for acetone. Preliminary testing of the sensor array in detecting breath samples from limited lung cancer patients, which consists of certain mixed VOCs as biomarkers, has also demonstrated the capability of breath recognition of lung cancer patients from healthy individuals under ambient sensing conditions. The recognition statistics were analyzed, showing the potential viability of achieving the desired sensitivity, selectivity, and accuracy in the breath sensing, the implication of which is discussed in terms of optimization of the sensor arrays for potential lung cancer screening.

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Sensor arrays based on nanoparticles for early detection of kidney injury by breath samples

Cited by 37 publications

References 55 publications

Spray layer-by-layer assembly of POSS functionalized CNT quantum chemo-resistive sensors with tuneable selectivity and ppm resolution to VOC biomarkers

Spray layer-by-layer assembly of POSS functionalized CNT quantum chemo-resistive sensors with tuneable selectivity and ppm resolution to VOC biomarkers

Monolayer-Capped Gold Nanoparticles for Disease Detection From Breath

Detection of mixed volatile organic compounds and lung cancer breaths using chemiresistor arrays with crosslinked nanoparticle thin films

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