Sensorineural hearing loss in hemorrhagic dengue?

Abstract

HighlightsWe presented a dengue hemorrhagic fever case that evolved with sudden deafness.Dengue hemorrhagic is a vascular leak syndrome.The etiology of sudden deafness is not well established in literature.Viral and vascular are possible causes of sudden deafness.The association of sudden deafness with dengue is been questioned.

Auditory findings associated with Zika virus infection: an integrative review

“…An association between flavivirus infection and hearing loss was suggested in two other reports concerning DENV infection cases. However, vascular impairment could not be ruled out in one of the reports, 56 describing an adult with hemorrhagic dengue, who presented deep and bilateral sensorineural hearing loss after 5 days of symptoms. In another report 57 of a child presenting vertical infection by DENV and a clinical condition of hemorrhagic shock who presented alteration during hearing screening, other risk indicators for hearing impairment were also present, such as low birth weight, use of ototoxic medications and permanence in the Neonatal ICU.…”

Transient Hearing Loss in Adults Associated With Zika Virus Infection

“…Hearing loss has been sporadically reported during infection with flaviviruses, including West Nile virus [ 6 , 7 ], DENV [ 8 ], and ZIKV [ 5 ]. A previously published case report suggesting ZIKV infection in association with hearing loss symptoms was not accompanied by audiometric tests and lacked strong evidence of the scenario [ 5 ].…”

“…Based on the sum of serologic results and the lack of additional convalescent samples to perform PRNT and hemagglutination assay to the other flavivirus and DENV serotypes, we considered patient 2 as inconclusive. Despite the extensive distribution of DENV in several countries, including Brazil [ 2 ], there is only 1 published case of sudden SNHL related to DENV hemorrhagic fever [ 8 ]. In addition, this DENV study had important confounding factors associated with hearing impairment that could not be excluded from the analysis, such as systemic vascular leak syndrome and antipyretic drugs [ 9 , 10 ], reducing the impact of DENV infection associated with hearing loss.…”

Different cochleovestibular manifestations and outcomes in patients diagnosed with dengue

“…Severe cases (Dengue Hemorrhagic Fever and Dengue Shock Syndrome) have thrombocytopenia, increased edema and hemorrhage due to endothelial cell dysfunction and vascular leak. 2 Shock occurs after 3–4 days.…”

“…Ear, nose and throat symptoms reported in dengue are similar to other viral infections. 2 However, cochleovestibular symptoms have rarely been reported.…”