Sensors for disposable bioreactors

Busse, Christoph; Biechele, Philipp; Vries, Ingo de; Reardon, Kenneth F.; Solle, Dörte; Scheper, Thomas

doi:10.1002/elsc.201700049

Cited by 47 publications

(43 citation statements)

References 128 publications

(167 reference statements)

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“…Recently, floating sensor devices without a physical connection to a reactor have been proposed. These floating sensors follow the flow in the bioreactor and collect data along a trajectory, transmitting it by wireless technology [ 64 ]. Zimmermann et al [ 65 ] developed the wireless spherical particles for the determination of fluid dynamics.…”

Section: State Of the Artmentioning

confidence: 99%

Towards smart biomanufacturing: a perspective on recent developments in industrial measurement and monitoring technologies for bio-based production processes

Gargalo

Udugama

Pontius

et al. 2020

Journal of Industrial Microbiology and Biotechnology

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The biomanufacturing industry has now the opportunity to upgrade its production processes to be in harmony with the latest industrial revolution. Technology creates capabilities that enable smart manufacturing while still complying with unfolding regulations. However, many biomanufacturing companies, especially in the biopharma sector, still have a long way to go to fully benefit from smart manufacturing as they first need to transition their current operations to an information-driven future. One of the most significant obstacles towards the implementation of smart biomanufacturing is the collection of large sets of relevant data. Therefore, in this work, we both summarize the advances that have been made to date with regards to the monitoring and control of bioprocesses, and highlight some of the key technologies that have the potential to contribute to gathering big data. Empowering the current biomanufacturing industry to transition to Industry 4.0 operations allows for improved productivity through information-driven automation, not only by developing infrastructure, but also by introducing more advanced monitoring and control strategies.

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Section: State Of the Artmentioning

confidence: 99%

Towards smart biomanufacturing: a perspective on recent developments in industrial measurement and monitoring technologies for bio-based production processes

Gargalo

Udugama

Pontius

et al. 2020

Journal of Industrial Microbiology and Biotechnology

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“…A number of resistance sensors and thermocouples exist on the market with different accuracy and operating ranges specifically designed to be implemented inside different types of bioreactors [ 188 , 189 , 190 , 191 , 192 ]. Other temperature sensors such as the ones based on thermistors (sensitive resistor made of metal oxide), gas/liquid-filled thermometers (where the volume of fluid changes with the temperature), bimetal (composed of two metal strips with different thermal expansion coefficients), silicon bandgap temperature sensors (where temperature depend on the forward voltage of a silicon diode) or infra-red (IR) sensors (which infers temperature from a portion of the thermal radiation) [ 193 , 194 ] may be used, however, these are not recommended for the highly accurate bioprocesses. Nevertheless, they might be a good choice for the single-use bioreactors, since some are relatively cheap and can be integrated with the SUBs.…”

Section: Sensorsmentioning

confidence: 99%

Cultivating Multidisciplinarity: Manufacturing and Sensing Challenges in Cultured Meat Production

Djisalov

Knežić

Podunavac

et al. 2021

Biology

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Meat cultivation via cellular agriculture holds great promise as a method for future food production. In theory, it is an ideal way of meat production, humane to the animals and sustainable for the environment, while keeping the same taste and nutritional values as traditional meat and having additional benefits such as controlled fat content and absence of antibiotics and hormones used in the traditional meat industry. However, in practice, there is still a number of challenges, such as those associated with the upscale of cultured meat (CM). CM food safety monitoring is a necessary factor when envisioning both the regulatory compliance and consumer acceptance. To achieve this, a multidisciplinary approach is necessary. This includes extensive development of the sensitive and specific analytical devices i.e., sensors to enable reliable food safety monitoring throughout the whole future food supply chain. In addition, advanced monitoring options can help in the further optimization of the meat cultivation which may reduce the currently still high costs of production. This review presents an overview of the sensor monitoring options for the most relevant parameters of importance for meat cultivation. Examples of the various types of sensors that can potentially be used in CM production are provided and the options for their integration into bioreactors, as well as suggestions on further improvements and more advanced integration approaches. In favor of the multidisciplinary approach, we also include an overview of the bioreactor types, scaffolding options as well as imaging techniques relevant for CM research. Furthermore, we briefly present the current status of the CM research and related regulation, societal aspects and challenges to its upscaling and commercialization.

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“…Although optical techniques present good limits of detection (LOD) and do not interfere with the cell activity [ 55 ], the integration of optical sensing in microfluidic chips and 3D bioreactors requires additional setting for an optical window to allow the light path [ 56 , 57 ]. Whereas the integration of optical sensors in microfluidic setting is limited, integrated electrochemical sensors facilitate the continuous monitoring of cellular microenvironment.…”

Section: Cell Culture Sensing On-chipmentioning

confidence: 99%

Electrochemical Sensing in 3D Cell Culture Models: New Tools for Developing Better Cancer Diagnostics and Treatments

Oliveira

Conceição

Kant

et al. 2021

Cancers

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Currently, conventional pre-clinical in vitro studies are primarily based on two-dimensional (2D) cell culture models, which are usually limited in mimicking the real three-dimensional (3D) physiological conditions, cell heterogeneity, cell to cell interaction, and extracellular matrix (ECM) present in living tissues. Traditionally, animal models are used to mimic the 3D environment of tissues and organs, but they suffer from high costs, are time consuming, bring up ethical concerns, and still present many differences when compared to the human body. The applications of microfluidic-based 3D cell culture models are advantageous and useful as they include 3D multicellular model systems (MCMS). These models have demonstrated potential to simulate the in vivo 3D microenvironment with relatively low cost and high throughput. The incorporation of monitoring capabilities in the MCMS has also been explored to evaluate in real time biophysical and chemical parameters of the system, for example temperature, oxygen, pH, and metabolites. Electrochemical sensing is considered as one of the most sensitive and commercially adapted technologies for bio-sensing applications. Amalgamation of electrochemical biosensing with cell culture in microfluidic devices with improved sensitivity and performance are the future of 3D systems. Particularly in cancer, such models with integrated sensing capabilities can be crucial to assess the multiple parameters involved in tumour formation, proliferation, and invasion. In this review, we are focusing on existing 3D cell culture systems with integrated electrochemical sensing for potential applications in cancer models to advance diagnosis and treatment. We discuss their design, sensing principle, and application in the biomedical area to understand the potential relevance of miniaturized electrochemical hybrid systems for the next generation of diagnostic platforms for precision medicine.

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Sensors for disposable bioreactors

Cited by 47 publications

References 128 publications

Towards smart biomanufacturing: a perspective on recent developments in industrial measurement and monitoring technologies for bio-based production processes

Towards smart biomanufacturing: a perspective on recent developments in industrial measurement and monitoring technologies for bio-based production processes

Cultivating Multidisciplinarity: Manufacturing and Sensing Challenges in Cultured Meat Production

Electrochemical Sensing in 3D Cell Culture Models: New Tools for Developing Better Cancer Diagnostics and Treatments

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