Sensory and pulmonary irritation of aliphatic amines in mice: A structure–activity relationship study

Abstract

The expiratory bradypnea indicative of upper airway irritation in mice was evaluated during a 15-min oronasal exposure to increasing concentrations of sixteen aliphatic amines. The airborne concentration resulting in a 50% decrease in the respiratory rate of mice (RD50) was calculated for each test compound. Moreover, the sixteen amines were tested for pulmonary irritation by measuring the decrease in respiratory rate of (non-anaesthetized) tracheally cannulated mice (RD50 TC). The RD50 and RD50 TC values and their ratios were related to n-octanol/water partition coefficients (log P). The RD50 values associated with exposure to saturated amines ranged from 17 to 300 ppm. The RD50TC values for these saturated amines ranged from 35 to 489 ppm. The RD50 and RD50TC values of saturated amines were closely related to the n-octanol/water partition coefficient, indicating that the more lipophilic amines are more irritant for the upper and lower respiratory tracts. The RD50TC/RD50 values were much less closely related to the n-octanol/water partition coefficient. Based on the results, tentative standards are suggested for the studied amines.

Annual Review of Cosmetic Ingredient Safety Assessments: 2007-2010

“…1 The Expert Panel reviewed newly available studies since that assessment along with updated frequency and concentration of use information. 2–12 The Expert Panel determined to not reopen this safety assessment and confirmed that diisopropylamine is safe as a cosmetic ingredient when used in products that do not contain N -nitrosating agents.…”

Physicochemical Modeling of Sensory Irritation in Humans and Experimental Animals

“…Nielsen and co-workers (44) correlated log RD 50 values against log K for solubility of gaseous compounds in wet octanol, but only for a restricted set of VOCs, and also used the water to octanol partition coefficient, as log Poct, as a descriptor; other workers did likewise (45), again for a very restricted set of VOCs. The meaning of the six descriptors is given in Table 2.…”