Sensory interactive zones in the rat cerebral cortex

Toldi, József; Fehér, O.; Wolff, Joachim R.

doi:10.1016/0306-4522(86)90166-1

Cited by 33 publications

(17 citation statements)

References 21 publications

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“…The nonlinear interactions observed during the ASEP resemble those noted in previous reports (Toldi et al, , 1986Di et al, 1994;Jiang et al, 1994;Barth et al, 1995). Much like the saturation of multisensory responses in the superior colliculus (Perrault et al, 2000), the cortical response to multisensory stimulation is less than the sum of the unisensory responses.…”

Section: Extra-and Intracellular Multisensory Responses In Mzsupporting

confidence: 73%

“…What does suggest a distinct multisensory responsiveness here is that the combined ASEP to stimulation does not equal the ASEPmod (the linear sum of the AEP and SEP). Prior work in rat cortex (Toldi et al, 1986;Di et al, 1994;Barth et al, 1995) found similar nonlinear multisensory responses. We also found a significant decrease in the poststimulus ASEP latency compared with the ASEPmod, with difference waveforms centered on the region overlap of AEP and SEP.…”

Section: Extra-and Intracellular Multisensory Responses In Mzmentioning

confidence: 55%

“…A smaller set of studies have also identified putative multisensory zones in the rat cortex (Toldi et al, , 1986Di et al, 1994;Jiang et al, 1994;Barth et al, 1995), suggesting that it may have functional subdivisions comparable to those in cats and primates. To explore this issue, we have mapped uni-and multisensory responses at high spatial resolution with multielectrode arrays placed on the cortical surface.…”

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confidence: 92%

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A multisensory zone in rat parietotemporal cortex: Intra‐ and extracellular physiology and thalamocortical connections

Brett-Green

Fifková

Larue

et al. 2003

J of Comparative Neurology

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Multisensory integration is essential for the expression of complex behaviors in humans and animals. However, few studies have investigated the neural sites where multisensory integration may occur. Therefore, we used electrophysiology and retrograde labeling to study a region of the rat parietotemporal cortex that responds uniquely to auditory and somatosensory multisensory stimulation. This multisensory responsiveness suggests a functional organization resembling multisensory association cortex in cats and primates. Extracellular multielectrode surface mapping defined a region between auditory and somatosensory cortex where responses to combined auditory/somatosensory stimulation were larger in amplitude and earlier in latency than responses to either stimulus alone. Moreover, multisensory responses were nonlinear and differed from the summed unimodal responses. Intracellular recording found almost exclusively multisensory cells that responded to both unisensory and multisensory stimulation with excitatory postsynaptic potentials (EPSPs) and/or action potentials, conclusively defining a multisensory zone (MZ). In addition, intracellular responses were similar to extracellular recordings, with larger and earlier EPSPs evoked by multisensory stimulation, and interactions suggesting nonlinear postsynaptic summation to combined stimuli. Thalamic input to MZ from unimodal auditory and somatosensory thalamic relay nuclei and from multisensory thalamic regions support the idea that parallel thalamocortical projections may drive multisensory functions as strongly as corticocortical projections. Whereas the MZ integrates uni- and multisensory thalamocortical afferent streams, it may ultimately influence brainstem multisensory structures such as the superior colliculus.

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Section: Extra-and Intracellular Multisensory Responses In Mzsupporting

confidence: 73%

Section: Extra-and Intracellular Multisensory Responses In Mzmentioning

confidence: 55%

mentioning

confidence: 92%

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A multisensory zone in rat parietotemporal cortex: Intra‐ and extracellular physiology and thalamocortical connections

Brett-Green

Fifková

Larue

et al. 2003

J of Comparative Neurology

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“…Once the electrode sites were no longer visible, a hydraulic microdrive (FHC, Bowdoinham, ME, USA) was used to slowly advance the array into the cortex until the 32 recording sites spanned a distance of 1.75–3.25 mm from the initial entry in the cortex. At this location, the recording sites were located within the V2L, a multisensory region responsive to auditory and visual stimuli (Toldi et al, 1986; Barth et al, 1995; Wallace et al, 2004; Hirokawa et al, 2008; Xu et al, 2014; Schormans et al, 2016; Figure 1). …”

Section: Methodsmentioning

confidence: 99%

Audiovisual Temporal Processing and Synchrony Perception in the Rat

Schormans

Scott

et al. 2017

Front. Behav. Neurosci.

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Extensive research on humans has improved our understanding of how the brain integrates information from our different senses, and has begun to uncover the brain regions and large-scale neural activity that contributes to an observer’s ability to perceive the relative timing of auditory and visual stimuli. In the present study, we developed the first behavioral tasks to assess the perception of audiovisual temporal synchrony in rats. Modeled after the parameters used in human studies, separate groups of rats were trained to perform: (1) a simultaneity judgment task in which they reported whether audiovisual stimuli at various stimulus onset asynchronies (SOAs) were presented simultaneously or not; and (2) a temporal order judgment task in which they reported whether they perceived the auditory or visual stimulus to have been presented first. Furthermore, using in vivo electrophysiological recordings in the lateral extrastriate visual (V2L) cortex of anesthetized rats, we performed the first investigation of how neurons in the rat multisensory cortex integrate audiovisual stimuli presented at different SOAs. As predicted, rats (n = 7) trained to perform the simultaneity judgment task could accurately (~80%) identify synchronous vs. asynchronous (200 ms SOA) trials. Moreover, the rats judged trials at 10 ms SOA to be synchronous, whereas the majority (~70%) of trials at 100 ms SOA were perceived to be asynchronous. During the temporal order judgment task, rats (n = 7) perceived the synchronous audiovisual stimuli to be “visual first” for ~52% of the trials, and calculation of the smallest timing interval between the auditory and visual stimuli that could be detected in each rat (i.e., the just noticeable difference (JND)) ranged from 77 ms to 122 ms. Neurons in the rat V2L cortex were sensitive to the timing of audiovisual stimuli, such that spiking activity was greatest during trials when the visual stimulus preceded the auditory by 20–40 ms. Ultimately, given that our behavioral and electrophysiological results were consistent with studies conducted on human participants and previous recordings made in multisensory brain regions of different species, we suggest that the rat represents an effective model for studying audiovisual temporal synchrony at both the neuronal and perceptual level.

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“…In this case, it is probably not useful to attempt to categorize the "locus" of summation as occurring at either a sensory or motor stage, since physiological studies have identified neurons within the superior colliculus that have multimodal receptive fields (Bell, Meredith, Van Opstal, & Munoz, 2005;Doubell, Skaliora, Baron, & King, 2003;Dräger & Hubel, 1975a, 1975bFort, Delpuech, Pernier, & Giard, 2002;Joassin, Maurage, Bruyer, Crommelinck, & Campanella, 2004;L. M. Miller & D'Esposito, 2005;Schneider & Kastner, 2005;Sparks, 1986;Stein & Meredith, 1993;Toldi, Fehér, & Wolff, 1986;; reviewed in Isa & Sasaki, 2002; but see Populin & Yin, 2002) and also generate a premotor discharge prior to specific trajectories of saccadic eye movements (e.g., Jay & Sparks, 1984;Meredith & Stein, 1986a;Patton, Belkacem-Boussaid, & Anastasio, 2002;Stein, 1978;Stein & Arigbede, 1972).…”

Section: Location Of Multimodal Convergencementioning

confidence: 99%