Sentinel Lymph Node Identification and Radical Hysterectomy with Lymphadenectomy in Early Stage Cervical Cancer: Laparoscopy Versus Laparotomy

Díaz-Feijoó, Berta; Gil‐Moreno, Antonio; Pérez-Benavente, María A.; Morchón, Sergio; Martínez-Palones, José M.; Xercavins, Jordi

doi:10.1016/j.jmig.2008.04.015

Cited by 43 publications

(23 citation statements)

References 36 publications

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“…There was good outcome and 100% detection rate, so the laparotomy procedure was not applied and no serious complications were found. The same results occurred during the study of Díaz-Feijoo et al 44 They noted success in SLN identification when they used the laparoscopic approach method, including shorter hospitalization, and lower blood loss than a laparotomy procedure. The overall survival and disease free survival were also similar between the two groups.…”

Section: Laparotomy and Laparoscopy Surgical Approachessupporting

confidence: 65%

Factors related to sentinel node identification in cervical cancer

Jarruwale

Huang

Benavides

et al. 2012

Gynecology and Minimally Invasive Therapy

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a b s t r a c tCervical cancer remains a common malignancy in women. Lymph node is one of the significant important prognostic factors. Until now, there is no reliable investigative study that can evaluate nodal status the same as the International Federation of Gynecology and Obstetrics (FIGO) clinical staging system. Radical hysterectomy and pelvic lymphadenectomy is still one option in the standard treatment of patients with early-stage cervical cancer that can reveal metastatic lymph node but which can also produce treatment-related morbidities and complications. Sentinel lymph node identification has become a valuable technique for nodal status assessment. If lymph node metastasis was identified early, then unnecessary invasive surgical operations and complications may be avoided. IntroductionThe third most common female malignancy is cervical cancer; 530,000 new cases were diagnosed in 2008 1 and 250,000 deaths from it occurred in 2005, approximately 80% of deaths happened in developing countries. 2 Cervical cancer is still the fifth leading cause of cancer death (9.1 per 100,000) of women in Taiwan. 3 Nodal status is the most significant negative prognostic factor of cervical cancer and may also reveal the lymphatic spreading. 4 Likely as radical hysterectomy accompanied with pelvic lymphadenectomy still have the role in early stage cervical cancer treatment. If the risk factors of the lymphatic metastasis were identified, surgery may be skipped to another appropriate modality primarily. 5 Even though significant morbidity possibly occurred if extensive surgical procedures were performed. According to operative disadvantages, many studies were progressed for decreasing those adverse effects. Basis of sentinel lymph node detectionSentinel lymph node (SLN) was defined as the first node in regional lymphatic basin that receives primary lymphatic drainage. 6,7 If SLN does not emerge, the remaining regional nodes should also be free of metastases. Thus SLN identification was an alternative resource for avoiding unnecessary lymphadenectomy and surgical interventions. The SLN concept is not only generated from many studies for nongynecologic tumors, such as penile cancer, 8 breast cancer, 9 and melanoma, 10,11 but it was also utilized for gynecologic malignancy treatment 12,13 thereafter. Nowadays, the practical lymphatic mapping methods use vital blue dye and lymphoscintigraphy techniques. 6,7,14 The modes for SLN identification are labeled as "hot" and/or "blue" as shown in Fig. 1. Types of materials and trial proceedings were selected dissimilarly. Materials used for detecting SLNThere are various reporting methods for SLN detection, e.g., vital blue dye and radioactive isotopes in single or a combined technique. 6,15 The three most commonly used vital dyes are isosulfan blue, patent blue violet, and methylene blue by injection intradermally 5e10 mm in depth around the primary cervical tumor, avoiding tumoral or intravascular infusion directly to avoidance of high background signal intensity that can decline S...

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Section: Laparotomy and Laparoscopy Surgical Approachessupporting

confidence: 65%

Factors related to sentinel node identification in cervical cancer

Jarruwale

Huang

Benavides

et al. 2012

Gynecology and Minimally Invasive Therapy

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“…Other studies have concluded that the laparoscopic, or laparoscopic-assisted vaginal radical hysterectomy results in less overall morbidity, less blood loss, fewer transfusions, a shorter hospitalization (by 3 days), a longer surgical time, and equal recurrence rates as compared to the classical open management [32,33,34,35,36]. The only prospective randomized study published so far dealing with such a comparison looked at small FIGO IB tumors, with only 15 patients who were randomized to either laparoscopic-assisted vaginal radical hysterectomy or radical abdominal hysterectomy.…”

Section: Laparoscopic Versus Open Surgical Accessmentioning

confidence: 99%

Surgical Treatment of Early-Stage Cervical Cancer

Brucker

Ulrich

2016

Oncol Res Treat

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Surgical treatment of cervical cancer has been a cornerstone in the management of this malignancy for more than 100 years. Today, for early-stage and low-risk cervical cancer, surgery is still considered the gold standard. If the preoperative assessment of the tumor reveals a situation prompting postoperative adjuvant radiochemotherapy, the latter should be planned as the primary treatment option, being preceded by staging laparoscopy including pelvic and paraaortic lymph node dissection. As an alternative to the open approach, the definitive surgical treatment should be either performed laparoscopically, or be laparoscopic-assisted, or laparoscopically robotic-assisted.

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“…The sentinel node procedure might be even more beneficial for patients with a positive sentinel node; instead of radical surgery, they could be rescheduled for primary chemoradiation, thereby preventing the morbidity of combined surgery and radiation. Díaz-Feijoo et al [26 ] showed reduced morbidity when performing sentinel node identification with radical hysterectomy by laparoscopy compared with laparotomy.…”

Section: Cervical Cancermentioning

confidence: 99%

The role of sentinel node biopsy in gynecological cancer: a review

Oonk

Nieuwenhof

Hullu

et al. 2009

Current Opinion in Oncology

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In early-stage vulvar cancer, data suggest that sentinel node biopsy could be offered as a treatment option instead of routine inguinofemoral lymphadenectomy. However, more (long-term follow-up) data are needed to further appreciate real clinical benefits. It is emphasized that the procedure should be performed by a skilled multidisciplinary team, centralized in oncology centers and preferably within the protection of clinical trials. For cervical cancer, data are promising, but routine application cannot be recommended due to lack of data on clinical utility and safety. For endometrial cancer, studies on the sentinel node biopsy are still in feasibility stage.

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Sentinel Lymph Node Identification and Radical Hysterectomy with Lymphadenectomy in Early Stage Cervical Cancer: Laparoscopy Versus Laparotomy

Cited by 43 publications

References 36 publications

Factors related to sentinel node identification in cervical cancer

Factors related to sentinel node identification in cervical cancer

Surgical Treatment of Early-Stage Cervical Cancer

The role of sentinel node biopsy in gynecological cancer: a review

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