Sentinel node biopsy in breast cancer: results in a large series

Carvalho, Solange Maria Torchia; Netto, Mário Mourão; Lima, Eduardo Nóbrega Pereira; Pimentel, Andréa; Makdissi, Fabiana Baroni Alves; Osório, Cynthia A. B. T.; Iyeyasu, Hirofumi; Collins, J.; Fontes, Cassiana Mendes Bertoncello; Perina, André; Soares, Fernando Augusto

doi:10.1590/s0100-879x2010007500048

Cited by 4 publications

(6 citation statements)

References 25 publications

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“…In all 4 experiments, a high rate of SLN detection and metastatic involvement and a low false‐negative rate were observed. These results were comparable to, if not better than, the reported blue dye and/or radiocolloid methods 44, 45. Furthermore, when blue dye or radiocolloid was juxtaposed against NIR‐guided SLNB, ICG in fact resulted in a higher detection rate and sensitivity 21, 24.…”

Section: Intraoperative Sln Mapping and Biopsy Using Icgsupporting

confidence: 73%

Current trends and emerging future of indocyanine green usage in surgery and oncology

Połom

Murawa

Rho

et al. 2011

Cancer

233

172

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Ever since Kitai first performed fluorescent navigation of sentinel lymph nodes (SLNs) using indocyanine green (ICG) dye with a charge-couple device and light emitting diodes, the intraoperative use of near infrared fluorescence has served a critical role in increasing our understanding in various fields of surgical oncology. Here the authors review the emerging role of the ICG fluorophore in the development of our comprehension of the lymphatic system and its use in SLN mapping and biopsy in various cancers. In addition, they introduce the novel role of ICG-guided video angiography as a new intraoperative method of assessing microvascular circulation. The authors attempt to discuss the promising potential in addition to assessing several challenges and limitations in the context of specific surgical procedures and ICG as a whole. PubMed and Medline literature databases were searched for ICG use in clinical surgical settings. Despite ICG's significant impact in various fields of surgical oncology, ICG is still in its nascent stages, and more in-depth studies need to be carried out to fully evaluate its potential and limitations. Cancer 2011;117:4812-22. V C 2011 American Cancer Society.KEYWORDS: sentinel lymph node, indocyanine green, lymphedema, free flaps, axillary reverse mapping, sentinel lymph node biopsy.Near infrared (NIR; emission spectra of $700-850 nm) 1 fluorophores are probes that have gained immense interest in various fields of biomedicine because of their minimal interfering absorption and fluorescence from biological samples, inexpensive laser diode excitation, reduced scattering, and enhanced tissue penetration depth. 2 However, to date, only 1 NIR probe, indocyanine green (ICG) has been approved by the US Food and Drug Administration (FDA); methylene blue is another FDA-approved probe that displays NIR properties, however, it is not considered a pure NIR probe. The former, ICG, is a water-soluble, anionic, amphiphilic tricarbocyanine probe 3 with a hydrodynamic diameter of 1.2 nm, and excitation and emission wavelengths in serum at 778 and 830, respectively. 4,5 For several years, it has been used in ophthalmic angiography 6 and for determining cardiac output 7 and hepatic function. 8 However, it has only recently shown real practicability and feasibility in the field of surgical oncology. Three major domains where NIR-guided ICG fluorophores have appeared most promising are: 1) sentinel lymph node (SLN) detection, 2) evaluation of lymphedema, and 3) assessment of microvascular circulation of free flaps in reconstructive surgery. Although several reviews have discussed the importance of NIR fluorophores (including ICG), 9-13 in this review we limit our discussion specifically to ICG in an attempt to attain a better understanding of its impact and challenges it presents in the field of surgical oncology.Intraoperative SLN Mapping and Biopsy Using ICG The significance of cancer treatment management in relation to first lymphatic drainage from the tumor site, the SLN, was first proposed by Cabanas...

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Section: Intraoperative Sln Mapping and Biopsy Using Icgsupporting

confidence: 73%

Current trends and emerging future of indocyanine green usage in surgery and oncology

Połom

Murawa

Rho

et al. 2011

Cancer

233

172

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“…Carvalho et al [14] obtained slightly higher sensitivity (67.7%) of intraoperative SLN assessment. Tille et al [19] presented even more favorable results.…”

Section: Discussionmentioning

confidence: 89%

“…The total percentage of SLN metastases in the studied group was 21.9% (the analysis concerned patients with primary breast cancer not larger than 15 mm). [14]) of all metastases (for the total number of SLN metastases diagnosed in the respective studies -18.1%, 24.2% and 25.7%).…”

Section: Discussionmentioning

confidence: 99%

Application of immunohistochemistry for detection of metastases in sentinel lymph nodes of non-advanced breast cancer patients

Nowikiewicz¹,

Śrutek²,

Zegarski³

2015

pjp

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“…Even though this technique was not included in our protocol, studies have shown that IHC has been reported to upstage the disease in approximately 10% of patients with negative SLN. 2 This can improve identification of micrometastasis and isolated tumor cells that maybe difficult to identify even with routine H&E technique.…”

Section: Discussionmentioning

confidence: 99%

“…The procedure is an extremely sensitive and specific method for predicting whether metastasis has occurred in regional lymph nodes. 2 The sensitivity of intraoperative FS in identifying nodal metastases within SLNs has been reported to vary within the range of 44% to 95%, with most studies reporting the sensitivity to be between 60-75%. 3 Advances in histopathologic methods for SLNs allow safe and accurate identification of early breast cancer without axillary node involvement, and SLN is now widely accepted and recommended by the American Society of Clinical Oncology (ASCO) 4 as it has shown greater benefit in reducing post-operative morbidity and complications like lymphedema, pain, numbness, and limited shoulder movement, which translates to better quality of life (QoL) outcomes.…”

Section: Introductionmentioning

confidence: 99%

Intraoperative Frozen Section Assessment of Sentinel Lymph Nodes in Breast Cancer: Six-Year Experience in a Tertiary Hospital

Tolentino-Molina¹,

Datay-Lim²,

Alcazaren³

2016

Phil Journal Path

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Sentinel node biopsy in breast cancer: results in a large series

Cited by 4 publications

References 25 publications

Current trends and emerging future of indocyanine green usage in surgery and oncology

Current trends and emerging future of indocyanine green usage in surgery and oncology

Application of immunohistochemistry for detection of metastases in sentinel lymph nodes of non-advanced breast cancer patients

Intraoperative Frozen Section Assessment of Sentinel Lymph Nodes in Breast Cancer: Six-Year Experience in a Tertiary Hospital

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