Sentinel node biopsy in squamous cell cancer of the oral cavity and oral pharynx: A diagnostic meta-analysis

Paleri, Vinidh; Rees, Guy; Arullendran, Puveendran; Shoaib, Taimur; Krishman, Suren

doi:10.1002/hed.20228

Cited by 146 publications

(77 citation statements)

References 37 publications

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“…One hundred percent agreement was observed between SLN and END using the kappa statistic (k = 1). A meta-analysis of 19 studies showed 97.7 % sentinel node identification rate and 92.6 % sensitivity with a false negative rate of 3 % [9]. Mahima Rakheja et al, in his study, showed that sentinel lymph node biopsy is feasible and helpful in N0 necks for detecting in lymphatic spread of oral malignancy [10].…”

Section: Feasibility and Accuracymentioning

confidence: 99%

Sentinel Lymph Node Biopsy in N0 Neck for Squamous Cell Carcinoma of Oral Cavity: a Prospective Study

Shivakumar

Goel

Manjunath

et al. 2016

Indian J Surg Oncol

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Oral cancers in India are very common. SLNB (sentinel lymph node biopsy) for the management of the cN0 neck provides proper staging with less morbidity. The study aims at assessment of the technical feasibility and accuracy of SLNB. Two by two table and Kappa statistic was used to compare SLN and END. In 14 cases out of 16 cases, SLN was identified. Sensitivity and specificity of 100 % were found. One hundred percent agreement was observed between SLN and END using kappa statistics. A meta-analysis of 19 studies showed 97.7 % sentinel node identification rate and 92.6 % sensitivity with a false negative rate of 3 %. In patients with N0 neck and negative SLN, neck dissection can be avoided decreasing morbidity of SOND. SLN biopsy has potential to become standard of care for managing N0 neck; however, long-term oncological results need to be evaluated.

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Section: Feasibility and Accuracymentioning

confidence: 99%

Sentinel Lymph Node Biopsy in N0 Neck for Squamous Cell Carcinoma of Oral Cavity: a Prospective Study

Shivakumar

Goel

Manjunath

et al. 2016

Indian J Surg Oncol

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“…Thesent inel node (SN) procedure is applied in a variety of tumor types, including head and neck squamous cell carcinoma (HNSCC) (1,2). Although, in general, results in HNSCC are good, adequate detection of the SN in floor-ofmouth tumors, compared with other sites, appeared problematic, as illustrated by significantly lower sensitivity and negative predictive value (1).…”

mentioning

confidence: 99%

⁸⁹Zr-Nanocolloidal Albumin–Based PET/CT Lymphoscintigraphy for Sentinel Node Detection in Head and Neck Cancer: Preclinical Results

Heuveling¹,

Visser²,

Baclayon³

et al. 2011

J Nucl Med

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Identifying sentinel nodes near the primary tumor remains a problem in, for example, head and neck cancer because of the limited resolution of current lymphoscintigraphic imaging when using 99m Tc-nanocolloidal albumin. This study describes the development and evaluation of a nanocolloidal albumin-based tracer specifically dedicated for high-resolution PET detection. Methods: 89 Zr was coupled to nanocolloidal albumin via the bifunctional chelate p-isothiocyanatobenzyldesferrioxamine B. Quality control tests, including particle size measurements, and in vivo biodistribution and imaging experiments in a rabbit lymphogenic metastasis model were performed. Results: Coupling of 89 Zr to nanocolloidal albumin appeared to be efficient, resulting in a stable product with a radiochemical purity greater than 95%, without affecting the particle size. PET showed distinguished uptake of 89 Zr-nanocolloidal albumin in the sentinel nodes, with visualization of lymphatic vessels, and with a biodistribution comparable to 99m Tc-nanocolloidal albumin. Conclusion: 89 Zr-nanocolloidal albumin is a promising tracer for sentinel node detection by PET.Key Words: sentinel node; PET/CT; 89 Zr; Nanocoll; head and neck cancer Thesent inel node (SN) procedure is applied in a variety of tumor types, including head and neck squamous cell carcinoma (HNSCC) (1,2). Although, in general, results in HNSCC are good, adequate detection of the SN in floor-ofmouth tumors, compared with other sites, appeared problematic, as illustrated by significantly lower sensitivity and negative predictive value (1). This is probably due to the short distance between the primary tumor and the first draining lymph nodes (SNs) in combination with the limited resolution of planar lymphoscintigraphy and SPECT. The injection site (around the primary tumor) produces a large focus of intense activity on planar lymphoscintigraphy, possibly hiding SNs near the primary tumor. As a result, second-echelon lymph nodes may erroneously be considered SNs; this is also true for SPECT: the added value of detecting foci hidden at planar scintigraphy may be offset by its lack of dynamic information with the typically fast kinetics of lymph drainage in HNSCC.PET provides dynamic 3-dimensional information at a higher spatial resolution than achievable with a g-camera.Theoretically, these characteristics may better differentiate between the first-and second-echelon nodes. To the best of our knowledge, no PET radiocolloids specifically dedicated to lymphatic mapping are clinically available yet. The aim of this study was to develop and evaluate in a rabbit lymphogenic metastasis model a 89 Zr (half-life, 78 h)-nanocolloidal albumin (Nanocoll; GE Healthcare)-based PET radiocolloid dedicated to SN detection. Results were compared with 99m Tc-nanocolloidal albumin ( 99m Tc half-life, 6 h). MATERIALS AND METHODSPreparation of 89 Zr-and 99m Tc-Nanocolloidal Albumin A 0.5-mg kit for the labeling of colloidal human serum albumin with 99m Tc was premodified with p-isothiocyanatobenzyldesferriox...

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“…; ipsilateral). Here it is shown to be quite sensitive at 97% on average (range: 96-100%); however, there is still a small false negative rate (average 4%, range: 0-12%) [18][19][20]. Potential explanations for this are skip metastases and 'masking' of a sentinel node by adjacent radiotracer uptake from carcinomas of the floor of mouth particularly in level I.…”

Section: Sentinel Nodesmentioning

confidence: 80%

Current State of Neck Dissection in the United States

Seethala

2009

Head and Neck Pathol

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The status of the cervical lymph nodes is the most important prognosticator in head and neck squamous cell carcinoma. The neck dissection is both a therapeutic and staging procedure and has evolved to include various types with standardized level designations (I-VI) for lymph node groups: the radical neck dissection, modified radical neck dissection, the selective neck dissection, and the extended neck dissection. The gross and histologic examination of a neck dissection should provide the critical information (size of metastasis, number of lymph nodes involved) for staging purposes. Additionally, extracapsular spread of lymph node metastasis must be reported because of its significance as an adverse prognosticator. Current dilemmas in nodal disease are the detection of micrometastases, isolated tumor cells, and molecular positivity. The significance of these categories of disease is still unclear, though they may explain a subset of the estimated 10% of the regional recurrences in the neck despite pathologic node negativity by traditional methods of evaluation. Sentinel lymph node biopsy has been recently applied to head and neck squamous cell carcinoma to enhance the management of the clinicoradiographically node negative patients. While still investigational, sentinel lymph node biopsy shows promise in selecting patients who require a neck dissection. Rapid highly automated real-time RT-PCR based platforms will allow for incorporation of molecular findings into the intraoperative evaluation of a sentinel lymph node.

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Sentinel node biopsy in squamous cell cancer of the oral cavity and oral pharynx: A diagnostic meta-analysis

Cited by 146 publications

References 37 publications

Sentinel Lymph Node Biopsy in N0 Neck for Squamous Cell Carcinoma of Oral Cavity: a Prospective Study

Sentinel Lymph Node Biopsy in N0 Neck for Squamous Cell Carcinoma of Oral Cavity: a Prospective Study

⁸⁹Zr-Nanocolloidal Albumin–Based PET/CT Lymphoscintigraphy for Sentinel Node Detection in Head and Neck Cancer: Preclinical Results

Current State of Neck Dissection in the United States

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Sentinel node biopsy in squamous cell cancer of the oral cavity and oral pharynx: A diagnostic meta-analysis

Cited by 146 publications

References 37 publications

Sentinel Lymph Node Biopsy in N0 Neck for Squamous Cell Carcinoma of Oral Cavity: a Prospective Study

Sentinel Lymph Node Biopsy in N0 Neck for Squamous Cell Carcinoma of Oral Cavity: a Prospective Study

89Zr-Nanocolloidal Albumin–Based PET/CT Lymphoscintigraphy for Sentinel Node Detection in Head and Neck Cancer: Preclinical Results

Current State of Neck Dissection in the United States

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⁸⁹Zr-Nanocolloidal Albumin–Based PET/CT Lymphoscintigraphy for Sentinel Node Detection in Head and Neck Cancer: Preclinical Results