Sentinel node detection in cervical cancer with 99mTc-phytate

Silva, Lucas B.; Silva-Filho, Agnaldo L.; Traiman, Paulo; Triginelli, Sérgio A.; Lima, Carla Flávia de; Siqueira, Cristiano Ferrari; Barroso, Adelanir Antonio; Rossi, Telma Maria F.F.; Pedrosa, Moisés Salgado; Miranda, Dairton; Melo, José Renan Cunha

doi:10.1016/j.ygyno.2005.02.014

Cited by 68 publications

(35 citation statements)

References 31 publications

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“…For the remaining studies, the full text was read. Finally, a total of 17 studies were included in the analysis, involving a total of 1,112 patients (5,6,(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28). The study selection process is summarized in Fig.…”

Section: Study Selection and Descriptionmentioning

confidence: 99%

Sentinel lymph node biopsy in cervical cancer: A meta-analysis

et al. 2013

Molecular and Clinical Oncology

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Abstract. Sentinel lymph node biopsy (SLNB) is used to determine the pathological status of the first lymph node receiving lymphatic drainage from the primary tumor. The diagnostic value of SLNB for the assessment of the nodal status in patients with cervical cancer has not been determined. Therefore, this meta-analysis was conducted to assess the diagnostic value of SLNB in cervical cancer. A search for related literature was performed using PubMed. Data were analyzed using a random effects model and a subgroup analysis was used to assess the diagnostic value of different practices during the process. A total of 17 studies involving a total of 1,112 patients were included in the analysis. The pooled sentinel lymph node (SLN) detection rate, sensitivity and negative predictive values were 92.2% [95% confidence interval (CI): 88.3-94.8%], 88.8% (95% CI: 85.1-91.7%) and 95.0% (95% CI: 92.8-96.6%), respectively. The subgroup analysis revealed that laparoscopy, tracer combination and immunohistochemistry were associated with a higher SLN detection rate. In conclusion, the SLNB in cervical cancer appears to be of diagnostic value, particularly the procedure with the combination of laparoscopy, combined tracers and immunohistochemistry. However, further studies are required to establish the clinical value of SLNB in cervical cancer.

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Section: Study Selection and Descriptionmentioning

confidence: 99%

Sentinel lymph node biopsy in cervical cancer: A meta-analysis

et al. 2013

Molecular and Clinical Oncology

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“…Barranger and colleagues 46 revealed the lower detection rate of SLN with a 20% false negative rate in locally advanced cervical cancer patients in the first laparoscopic SLN detection report, but they found no false negative rate in early cervical cancer stages. Silva LB et al 35 expressed that the SLN identification rate was less than 40% in advanced cervical cancer stages, which was the same as Altgassen and associates 42 who revealed a 94% sentinel node detection rate in tumor mass size 2.0 cm or less which has higher than tumor size more than 2.0 in diameter (83.6%) significantly. However, Daraï E et al 30 found that two staged IIB patients had metastasis negative in SLN and positive in non-SLN; furthermore, nine cases without parametrial involvement were found in two patients (22.2%).…”

Section: Cervical Tumor Size Affects Sln Detectionmentioning

confidence: 54%

“…Angioli et al 32 reported a 89% detection rate by lymphoscintigraphy in 33/ 35 cervical cancer patients, and there are some reports that show a higher detection rate nearly or equal to 100%. 35,36 Malur et al 16 reported a detection rate of 76.2% in radiolabeled albumin but 55.5% in the blue dye group with 50% sensitivity. O'Boyle et al 33 studies isosulphan blue dye and identified SLN in 20 patients with early stage cervical carcinoma, reporting a 60% detection rate and 50% sensitivity.…”

Section: Single Technique In Sln Detectionmentioning

confidence: 99%

Factors related to sentinel node identification in cervical cancer

Jarruwale

Huang

Benavides

et al. 2012

Gynecology and Minimally Invasive Therapy

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a b s t r a c tCervical cancer remains a common malignancy in women. Lymph node is one of the significant important prognostic factors. Until now, there is no reliable investigative study that can evaluate nodal status the same as the International Federation of Gynecology and Obstetrics (FIGO) clinical staging system. Radical hysterectomy and pelvic lymphadenectomy is still one option in the standard treatment of patients with early-stage cervical cancer that can reveal metastatic lymph node but which can also produce treatment-related morbidities and complications. Sentinel lymph node identification has become a valuable technique for nodal status assessment. If lymph node metastasis was identified early, then unnecessary invasive surgical operations and complications may be avoided. IntroductionThe third most common female malignancy is cervical cancer; 530,000 new cases were diagnosed in 2008 1 and 250,000 deaths from it occurred in 2005, approximately 80% of deaths happened in developing countries. 2 Cervical cancer is still the fifth leading cause of cancer death (9.1 per 100,000) of women in Taiwan. 3 Nodal status is the most significant negative prognostic factor of cervical cancer and may also reveal the lymphatic spreading. 4 Likely as radical hysterectomy accompanied with pelvic lymphadenectomy still have the role in early stage cervical cancer treatment. If the risk factors of the lymphatic metastasis were identified, surgery may be skipped to another appropriate modality primarily. 5 Even though significant morbidity possibly occurred if extensive surgical procedures were performed. According to operative disadvantages, many studies were progressed for decreasing those adverse effects. Basis of sentinel lymph node detectionSentinel lymph node (SLN) was defined as the first node in regional lymphatic basin that receives primary lymphatic drainage. 6,7 If SLN does not emerge, the remaining regional nodes should also be free of metastases. Thus SLN identification was an alternative resource for avoiding unnecessary lymphadenectomy and surgical interventions. The SLN concept is not only generated from many studies for nongynecologic tumors, such as penile cancer, 8 breast cancer, 9 and melanoma, 10,11 but it was also utilized for gynecologic malignancy treatment 12,13 thereafter. Nowadays, the practical lymphatic mapping methods use vital blue dye and lymphoscintigraphy techniques. 6,7,14 The modes for SLN identification are labeled as "hot" and/or "blue" as shown in Fig. 1. Types of materials and trial proceedings were selected dissimilarly. Materials used for detecting SLNThere are various reporting methods for SLN detection, e.g., vital blue dye and radioactive isotopes in single or a combined technique. 6,15 The three most commonly used vital dyes are isosulfan blue, patent blue violet, and methylene blue by injection intradermally 5e10 mm in depth around the primary cervical tumor, avoiding tumoral or intravascular infusion directly to avoidance of high background signal intensity that can decline S...

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“…Aynı çalışmada SLN'nin %44'ünün eksternal iliak, %39'unun obturatuar, %8,3'ünün internal iliak lenf nodlarını tuttuğunu, çalışmanın sensitivitesinin %87,5, yanlış negatiflik oranının %11 olduğunu rapor etmişlerdir. 32 Ying ve ark. benzer bir çalışmada sensitiviteyi %75, spesifisiteyi %100 ve doğruluk oranını ise %95 olarak bildirmişlerdir.…”

Section: Servi̇ks Kanseri̇unclassified