Sentinel Node Detection Method Using Contrast-Enhanced Ultrasonography with Sonazoid in Breast Cancer: Preliminary Clinical Study

Omoto, Kiyoka; Matsubara, Hiroaki; Take, Natsuki; Hozumi, Yasuo; Takehara, Megumi; Omoto, Yoko; Shiozawa, Mikio; Mizunuma, Hirobumi; Harashima, Hiroki; Taniguchi, Nobuyuki; Kawano, Motoharu

doi:10.1016/j.ultrasmedbio.2009.02.004

Cited by 95 publications

(99 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Several recent publications have described the use of CEUS to localize SLNs in humans. [45][46][47] The largest study was by Sever et al, 45 who investigated the use of CEUS for preoperative localization of SLNs in 54 patients with breast cancer after periareolar injection of SonoVue (Bracco Diagnostics, Milan, Italy). The sensitivity of SLN detection by CEUS was 89% compared to lymphoscintigraphy and blue dye-guided surgery.…”

mentioning

confidence: 99%

Contrast-Enhanced Ultrasound Imaging of Sentinel Lymph Nodes After Peritumoral Administration of Sonazoid in a Melanoma Tumor Animal Model

Goldberg

Merton

Liu

et al. 2011

Journal of Ultrasound in Medicine

View full text Add to dashboard Cite

etection and characterization of sentinel lymph nodes (SLNs) are important for the management of patients who have a variety of malignancies, including melanoma, breast, colon, and other cancers. [1][2][3][4] Various techniques and imaging agents have been developed to map lymphatic drainage from tumors, including the use of blue dye with surgical dissection and injection of radiopharmaceuticals followed by evaluation with a gamma camBarry B. Goldberg, MD, Daniel A. Merton, BS, RDMS, Ji-Bin Liu, MD, Flemming Forsberg, PhD, Kaijun Zhang, PhD, Madhukar Thakur, PhD, Stephanie Schulz, PhD, Robin Schanche, BS, George F. Murphy, MD, Scott A. Waldman, MD, PhD Received October 6, 2010, ORIGINAL RESEARCHObjectives-The purpose of this study was to compare lymphosonography (ie, contrast-enhanced ultrasound imaging [US] after interstitial injection of a US contrast agent) for the detection of sentinel lymph nodes (SLNs) in swine with naturally occurring melanoma tumors to lymphoscintigraphy using blue dye-guided surgical dissection as the reference standard. Also, we sought to determine if lymphosonography can be used to characterize SLNs.Methods-Sixty-three swine with 104 melanomas were evaluated. Contrast-specific US was performed after peritumoral injection (1 mL dose) of Sonazoid (GE Healthcare, Oslo, Norway). Lymphoscintigraphy was performed after peritumoral injections of technetium Tc 99m sulfur colloid. Peritumoral injection of 1% Lymphazurin (Ben Venue Labs, Inc, Bedford, OH) was used to guide SLN resection. The accuracy of SLN detection with the two imaging modalities was compared using the McNemar test. The SLNs were qualitatively and quantitatively characterized as benign or malignant based on the lymphosonography results with histopathology and RNA analyses used as the reference standards.Results-Blue dye-guided surgery identified 351 SLNs. Lymphosonography detected 293 SLNs and 11 false-positives, while lymphoscintigraphy detected 231 SLNs and 20 false-positives. The accuracy of SLN detection was 81.8% for lymphosonography, which was significantly higher than the 63.2% achieved with lymphoscintigraphy (P < .0001). The accuracy of lymphosonography for SLN characterization was 80%. When the size of the enhanced SLN was taken into consideration to characterize SLNs, the accuracy was 86%.Conclusions-Lymphosonography is statistically better than lymphoscintigraphy for the detection of SLNs in this animal model. The ability to use lymphosonography as a means to characterize SLNs as benign or malignant is limited.

show abstract

mentioning

confidence: 99%

Contrast-Enhanced Ultrasound Imaging of Sentinel Lymph Nodes After Peritumoral Administration of Sonazoid in a Melanoma Tumor Animal Model

Goldberg

Merton

Liu

et al. 2011

Journal of Ultrasound in Medicine

View full text Add to dashboard Cite

show abstract

“…15 Sonazoid consists of lipid stabilised perfluorobutane microbubbles, and has also been used in Japan to detect the SLNs in breast cancer patients, but is not available in Europe. 16,17 The microbubble agent used in this study was SonoVue (Bracco Imaging), which has been used in a similar fashion to good effect by Sever et al 5 It is licensed for intravenous (not intradermal) use and is most commonly used in cardiac and liver imaging. 18 To visualise the microbubbles, it is essential that ultrasound machine settings are optimised.…”

Section: Discussionmentioning

confidence: 99%

Microbubble detection and ultrasound-guided vacuum-assisted biopsy of axillary lymph nodes in patients with breast cancer

et al. 2017

View full text Add to dashboard Cite

“…The US contrast agent (SonoVue 0.2-0.5 ml [41], Sonazoid 2 ml [42]) is injected intradermally or subdermally at the upper outer periareolar skin or subareolarly. The breast is massaged for a few seconds.…”

Section: Non-operative Axillary Stagingmentioning

confidence: 99%

New Technologies for Sentinel Lymph Node Detection

Goyal¹

2018

Breast Care

View full text Add to dashboard Cite

The ‘standard of care' method for sentinel node mapping is the combination technique using radioisotope and blue dye although some centres use radioisotope or blue dye alone. Radioisotope usage requires licensing, has regulatory issues around handling and disposal of waste, and logistically may be unavailable or difficult to implement in some centres or less developed country. This has led to the development of alternative methods such as superparamagnetic iron oxide (SPIO), fluorescence techniques using indocyanine green (ICG) or fluorescein, computed tomography lymphography, and contrast-enhanced ultrasound scan (CEUS) using microbubbles. The newer techniques will potentially enable a more widespread adoption of this procedure; however, a common barrier for these techniques is the lack of standardisation and no randomised trials to evaluate their effectiveness against the current standard of care. Furthermore, many of these techniques are more costly and may become redundant in node-negative patients with small tumours if ongoing trials show that sentinel node biopsy offers no additional benefit to grey-scale axillary ultrasound. This review discusses the new techniques for sentinel node mapping that have emerged including their pros and cons.

show abstract

Sentinel Node Detection Method Using Contrast-Enhanced Ultrasonography with Sonazoid in Breast Cancer: Preliminary Clinical Study

Cited by 95 publications

References 22 publications

Contrast-Enhanced Ultrasound Imaging of Sentinel Lymph Nodes After Peritumoral Administration of Sonazoid in a Melanoma Tumor Animal Model

Contrast-Enhanced Ultrasound Imaging of Sentinel Lymph Nodes After Peritumoral Administration of Sonazoid in a Melanoma Tumor Animal Model

Microbubble detection and ultrasound-guided vacuum-assisted biopsy of axillary lymph nodes in patients with breast cancer

New Technologies for Sentinel Lymph Node Detection

Contact Info

Product

Resources

About