Sentinel node in breast cancer procedural guidelines

Buscombe, J. R.; Paganelli, Giovanni; Burak, Zeynep; Waddington, W; Maublant, J.; Prats, E.; Palmedo, Holger; Schillaci, Orazio; Maffioli, Lorenzo; Laßmann, Michael; Chiesa, Carlo; Bombardieri, Emilio; Chiti, Arturo

doi:10.1007/s00259-007-0614-z

Cited by 111 publications

(72 citation statements)

References 20 publications

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“…Therefore, there is a considerable need to address biocompatibility and biosafety concerns associated with their usage in a variety of applications. Buscombe et al [26] explanation that the sentinel lymph node (SLN) is defined as the first regional lymph node receiving lymphatic drainage from a malignant tumor and the first node to which metastatic cells are likely to anchor. Therefore, accurate detection and characterization of the SLN is of major importance for cancer staging and for the choice of therapy in patients.…”

Section: Hematology Findings Of Current Study Inmentioning

confidence: 99%

Treatment of Anemia Progression via Magnetite and Folate NanoparticlesIn Vivo

Elsayed¹,

Al-Sherbini

Abd-Elhady

et al. 2014

ISRN Nanotechnology

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Iron deficiency anemia is a major global public health problem. Food fortification with iron (Fe) can be an effective strategy to control iron deficiency. An iron oxide nanoparticle (NP) is a new physical and chemical property form. These properties (small particle size, unique physical properties) make nanoiron a great scientific interest especially in the treatment of anemia. The study aimed to reduce anemia by nanoparticles (NPs). Forty-eight adult female Sprague-Dewily rats were divided into four groups (12 rats each). Group A represented a negative control. Other groups were fed standard diet iron free and three time of require zinc to reach anemic. Group B fed standard diet with ferrous sulfate until the improvement of the situation of anemia or for 8 weeks. Groups C and D were divided into three subgroups; each subgroup was fed a dose from magnetite or folate coated magnetite NPs. Results showed that symptoms of loss of appetite and severe lethargy demonstrate that magnetite and folate-coated magnetite nanoparticles have serious toxicological effects in vivo. Some doses from NPs improve blood picture during 2 weeks but change in histopathology examinations were occur in some groups within 2 weeks. Nanoparticles were considered the toxicological hazards especially the size of less than 54 nm.

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Section: Hematology Findings Of Current Study Inmentioning

confidence: 99%

Treatment of Anemia Progression via Magnetite and Folate NanoparticlesIn Vivo

Elsayed¹,

Al-Sherbini

Abd-Elhady

et al. 2014

ISRN Nanotechnology

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“…Therefore, accurate detection and characterization of the SLN is of major importance for cancer staging and for the choice of therapy in patients with breast cancer and malignant melanoma. The current gold standard relies on lymphoscintigraphy after intradermal injection of radiolabeled colloids and blue dye to intraoperatively identify the SLN by dissection and histopathologic examination (2). The radiopharmaceuticals most frequently used for SLN imaging are 99m Tc-labeled colloids and macromolecules such as trisulfide, dextran, and human serum albumin (3)(4)(5).…”

mentioning

confidence: 99%

^99mTc-Labeled Superparamagnetic Iron Oxide Nanoparticles for Multimodality SPECT/MRI of Sentinel Lymph Nodes

Madru¹,

Kjellman²,

Olsson³

et al. 2012

J Nucl Med

159

134

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The purpose of this study was to develop multimodality SPECT/ MRI contrast agents for sentinel lymph node (SLN) mapping in vivo. Methods: Nanoparticles with a solid iron oxide core and a polyethylene glycol coating were labeled with 99m Tc. The labeling efficiency was determined with instant thin-layer chromatography and magnetic separation. The stability of the radiolabeled superparamagnetic iron oxide nanoparticles (SPIONs) was verified in both sterile water and human serum at room temperature 6 and 24 h after labeling. Five Wistar rats were injected subcutaneously in the right hind paw with 99m Tc-SPIONs (25-50 MBq, ;0.2 mg of Fe) and sacrificed 4 h after injection. Two animals were imaged with SPECT/MRI. All 5 rats were dissected; the lymph nodes, liver, kidneys, spleen, and hind paw containing the injection site were removed and weighed; and activity in the samples was measured. The microdistribution within the lymph nodes was studied with digital autoradiography. Results: The efficiency of labeling of the SPIONs was 99% 6 h after labeling in both water and human serum. The labeling yield was 98% in water and 97% in human serum 24 h after labeling. The SLN could be identified in vivo with SPECT/MRI. The accumulation of 99m Tc-SPIONs (as the percentage injected dose/g [%ID/g]) in the SLN was 100 % ID/g, whereas in the liver and spleen it was less than 2 %ID/g. Digital autoradiography images revealed a nonhomogeneous distribution of 99m Tc-SPIONs within the lymph nodes; nanoparticles were found in the cortical, subcapsular, and medullary sinuses. Conclusion: This study revealed the feasibility of labeling SPIONs with 99m Tc. The accumulation of 99m Tc-SPIONs in lymph nodes after subcutaneous injection in animals, verified by SPECT/MRI, is encouraging for applications in breast cancer and malignant melanoma. The sentinel lymph node (SLN) is defined as the first regional lymph node receiving lymphatic drainage from a malignant tumor (1) and the first node to which metastatic cells are likely to anchor. Therefore, accurate detection and characterization of the SLN is of major importance for cancer staging and for the choice of therapy in patients with breast cancer and malignant melanoma. The current gold standard relies on lymphoscintigraphy after intradermal injection of radiolabeled colloids and blue dye to intraoperatively identify the SLN by dissection and histopathologic examination (2). The radiopharmaceuticals most frequently used for SLN imaging are 99m Tc-labeled colloids and macromolecules such as trisulfide, dextran, and human serum albumin (3-5). The current technique, however, is limited because of the nonspecificity of the tracer and the lack of anatomic information in scintigraphic images. Preoperative planning and identification of the SLN often rely on the experience of the surgeon.We propose combining information from high-resolution MRI and high-sensitivity SPECT images to provide more accurate and less invasive identification of the SLN before surgery. The use of radioactivity would help to ...

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“…Emziren hastalar ise tetkik yapıldıktan 24 saat sonra emzirmeye devam edebilmektedir (15). SLBB'nin uygulandığı tümörler çocuklarda nadir olmakla birlikte gerekli doz ayarlaması yapılarak, SLBB güvenle yapılabilmektedir.…”

Section: Sentinel Lenf Bezi Biyopsisi Dikkat Edilmesi Gerekenlerveuyaunclassified

Sentinel Lymph Node Biopsy: Actual Approaches

Tuncel¹,

Salancı²,

Bozkurt³

2017

Nts

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Öz Abstract GirişKanser yayılımında en önemli yollardan biri lenfatik yayılımdır. On yedinci yüzyılda lenfatik sistemin tanımlanması ve ardından kanserdeki rolünün saptanmaya başlaması ile bu konuda çeşitli çalışmalar yapılmıştır. Bu araştırmaların sonucunda bugün kanserin yerleştiği bölgeye bağlı olarak önce bölgesel lenf bezlerine ilerlediği ve klinik tanıdan çok daha önce bu bölgesel lenf bezlerinde mikrometastazların gerçekleştiği bilinmektedir. Bu bilgi özellikle meme kanseri ve malign melanom gibi kanserlerde sentinel lenf bezi (SLB) kavramının doğmasını sağlamıştır (1). İlk SLB tanımı Cabanas tarafından penil kanserde yapılmıştır (2). Lenfosintigrafinin SLB saptanmasında kullanılması Chiappa ve ark.'nın 1966'da testiküler kanserlerde yaptığı çalışma ile başlamıştır (3). Morton ve ark.'nın 194 malign melanom hastasında lenfosintigrafi kullanılarak lenfatik yayılımın araştırdığı çalışma SLB'nin örneklemesinin önünü açmış olup, günümüzde SLB sintigrafisi rutin uygulama kılavuzlarında yerini almıştır (4). Meme kanserlerinde de Christensen ve ark. ile başlayan çalışmalar koruyucu meme cerrahisi uygulamalarının yaygınlaşmasına ve hastaların daha az cerrahi komplikasyon ile tedavi edilmelerine olanak vermiştir (5). Son yıllarda gelişen görüntüleme ve intraoperatif deteksiyon teknolojileri sayesinde SLB biyopsisinin (SLBB) başarısı ve kullanım sıklığı

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Sentinel node in breast cancer procedural guidelines

Abstract: Procedure guidelines for scintigraphic detection of sentinel node in breast cancer are presented.

Cited by 111 publications

References 20 publications

Treatment of Anemia Progression via Magnetite and Folate NanoparticlesIn Vivo

Treatment of Anemia Progression via Magnetite and Folate NanoparticlesIn Vivo

^99mTc-Labeled Superparamagnetic Iron Oxide Nanoparticles for Multimodality SPECT/MRI of Sentinel Lymph Nodes

Sentinel Lymph Node Biopsy: Actual Approaches

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