Sentinel Node Mapping for Colorectal Cancer With Radioactive Tracer

Kitagawa, Yuko; Watanabe, Masahiko; Hasegawa, Hirotoshi; Yamamoto, Seiichiro; Fujii, Hirofumi; Yamamoto, Kentaro; Matsuda, Jun; Mukai, Makio; Kubo, Atsushi; Kitajima, Masaki

doi:10.1007/s10350-004-6453-0

Cited by 66 publications

(60 citation statements)

References 22 publications

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“…Large prospective trials using a combination of blue dye and radiocolloid, such as used in SLN mapping for breast cancer and melanoma, may reveal higher success rates of this technique in colon cancer. 49 Kitagawa et al 56 reported the only study to date that investigated the feasibility of SLN mapping using preoperative endoscopic injection of only technetiumlabeled tin colloid in patients with sigmoid colon and rectal cancer. Since only limited results are available regarding the feasibility and accuracy of radiocolloidguided SLN mapping in colon cancer, more studies should be performed in which the value of radiocolloid as a tracer is investigated.…”

Section: Figmentioning

confidence: 99%

Sentinel Lymph Node Mapping in Colon Cancer: Current Status

et al. 2007

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Background: The primary role of sentinel lymph node (SLN) mapping in colon cancer is to increase the accuracy of nodal staging by identifying those lymph nodes with the greatest potential for harbouring metastatic disease. Ultrastaging techniques aim to identify the otherwise undetected metastases. Until now, no consensus exists as to the most optimal procedure in patients with colon cancer.Methods: A systematic literature search on the value of different SLN mapping techniques in patients with colon cancer was performed using the electronic search engine PubMed. Prospective studies published before 1 December 2005 were included and further articles were selected by cross-referencing. The results of different techniques using either blue dye or radiocolloid, were investigated.Results: The literature search yielded 17 relevant articles. SLN mapping using blue dye was described in 15 studies. Two studies reported the results of SLN mapping using a combination of blue dye and radiocolloid. The reported results on identification rate varied between 71 and 100%. Accuracy rates were between 78 and 100%, sensitivity rates between 25 and 100% and true upstaging rates between 0 and 26%. The results were not affected by the addition of radiocolloid to blue dye.Conclusions: Sentinel lymph node mapping in patients with colon cancer remains an experimental procedure with varying results. Further evaluation may lead to a standardized technique that offers the potential for significant upstaging of stage II patients. This may have important implications as to tailor adjuvant chemotherapeutic regimens in these patients.

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Section: Figmentioning

confidence: 99%

Sentinel Lymph Node Mapping in Colon Cancer: Current Status

et al. 2007

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“…Four studies reported sentinel node biopsy using both blue dye and radioactive tracer [23,[26][27][28] and in two studies only radioactive tracer was used [18,29]. The moment of injection was usually in vivo and the site of injection was mostly subserosally and sometimes submucosally during an endoscopy or ex vivo procedure.…”

Section: Discussionmentioning

confidence: 99%

“…The mean number of SLN found per patient ranges from 1.5 [10] to 3.5 [18]. The figures of upstaging (0-24%) vary considerably among studies [10,14,17,[19][20][21][22][23][24].…”

Section: Discussionmentioning

confidence: 99%

Lymphoscintigraphic localization of sentinel node in early colorectal cancer: Results of a monocentric study

Sandrucci

Mussa

Goss

et al. 2007

Journal of Surgical Oncology

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“…Quando observados somente os trabalhos que utilizaram o método combinado (corante e radiofármaco), como nesta avaliação, a taxa média foi de 28%, variando de 0 a 50% 19,27,29 . De acordo com o estudo de validade deste trabalho, a sensibilidade foi 66,7%, enquanto na literatura varia de 40 a 100% 17,26,28 . Há um consenso que quanto mais avançado for o tumor, mais alto deverá ser o índice de falsonegativo e menor a sensibilidade.…”

Section: Falso-negativo E Sensibilidadeunclassified

Pesquisa de linfonodo-sentinela em pacientes com adenocarcinoma de cólon

Freitas¹,

Nunes²,

Wainstein³

et al. 2008

Rev bras. colo-proctol.

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Trabalho realizado na Universidade Federal de Minas Gerais (UFMG); Fundação Hospitalar do Estado de Minas Gerais (FHEMIG); Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG); Instituto de Pesquisa Biocâncer. Recebido em 07/04/2008 Aceito para publicação em 22/04/2008 INTRODUÇÃOA incidência de câncer colorretal no Brasil é de aproximadamente 25.000 casos por ano 1 . O tratamento de escolha para tumores de cólon é a remoção em bloco da neoplasia e de todos os tecidos envolvidos na drenagem linfática, que é a principal via de disseminação desses tumores 2 . Os estadiamentos clássicos propostos têm como principal objetivo diagnosticar metástase nos linfonodos. Quando presente, o paciente é encaminhado para quimioterapia adjuvante, que aumenta o tempo livre de doença e a sobrevida 3 . Sabe-se que um quarto dos pacientes operados por adenocarcinoma de cólon e sem linfonodos comprometidos à histologia de rotina, portanto, sem indicação de terapia adjuvante, evolui para óbito em até cinco anos por recorrência local do tumor ou metástase à distância 4,5,6 . O linfonodo-sentinela é considerado o primeiro a receber drenagem linfática do tumor e, desta forma, o mais provável de conter metástases 7 . Nele, podem-se empregar meios diagnósticos mais eficazes, como exame histológico com multissecção e imunoistoquímica, inviáveis e de alto custo para serem realizadas em todos os linfonodos dissecados 8 . Diante desses fatos, este trabalho se propõe a avaliar a pesquisa de linfonodo-sentinela nos tumores do intestino grosso por meio de corante e radiofármaco no perioperatório; e utilizar além da histologia de rotina

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Sentinel Node Mapping for Colorectal Cancer With Radioactive Tracer

Cited by 66 publications

References 22 publications

Sentinel Lymph Node Mapping in Colon Cancer: Current Status

Sentinel Lymph Node Mapping in Colon Cancer: Current Status

Lymphoscintigraphic localization of sentinel node in early colorectal cancer: Results of a monocentric study

Pesquisa de linfonodo-sentinela em pacientes com adenocarcinoma de cólon

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