Sentinel node mapping performed before preoperative chemotherapy may avoid axillary dissection in breast cancer patients with negative or micrometastatic sentinel nodes

Schrenk, Peter; Tausch, Christoph; Wölfl, S; Bogner, Stephan; Fridrik, Michael A.; Wayand, W.

doi:10.1016/j.amjsurg.2007.08.068

Cited by 27 publications

(19 citation statements)

References 37 publications

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“…Contrary to the high number of studies reporting SLNB after NAC, only a few studies have reported the results of performing SLNB before NAC. [16][17][18][19][20][21][22][23] The candidates for SLNB in this setting were patients with large tumors and clinically negative nodes before NAC. Two studies demonstrated that SLNB can also provide accurate results in patients with large breast tumors not treated with chemotherapy.…”

Section: Sentinel Lymph Node Biopsy Before Neoadjuvant Chemotherapymentioning

confidence: 99%

“…SLNB is considered to be contraindicated for patients on NAC for several reasons; however, many studies have reported positive results of SLNB before and/or after NAC. [9][10][11][12][13][14][15][16][17][18][19][20][21][22][23] In this review article, we discuss the issues surrounding SLNB performed before or after NAC by reviewing the published literature and our experience, based on which we assess the optimal timing for SLNB in the NAC setting.…”

Section: Introductionmentioning

confidence: 99%

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Sentinel lymph node biopsy before versus after neoadjuvant chemotherapy for breast cancer

Shimazu

Noguchi

2011

Surg Today

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Axillary lymph node status is the most important prognostic factor in the treatment of breast cancer. In recent years, sentinel lymph node biopsy (SLNB) has replaced conventional axillary lymph node dissection for predicting axillary lymph node status with higher accuracy. Moreover, neoadjuvant chemotherapy (NAC) is being used increasingly to treat not only patients with locally advanced inoperative breast cancer, but also those with initially operable breast cancer. The application of SLNB has now expanded to include this patient population, who were not previously considered good candidates for SLNB. A number of recent studies have evaluated the feasibility and accuracy of SLNB after NAC in breast cancer patients. Moreover, SLNB has been shown to be accurate in patients scheduled to receive NAC, and repeat SLNB has been performed after NAC for patients with positive nodes detected by the initial SLNB before NAC. Thus, the optimal timing of SLNB for patients with breast cancer in the neoadjuvant setting remains controversial. This article reviews the issues surrounding SLNB before vs. after NAC, according to the published literature and our experience.

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Section: Sentinel Lymph Node Biopsy Before Neoadjuvant Chemotherapymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Sentinel lymph node biopsy before versus after neoadjuvant chemotherapy for breast cancer

Shimazu

Noguchi

2011

Surg Today

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“…Schrenk et al [7] demonstrated a 0% positivity rate after PCT when the sentinel node was negative or had only micrometastatic disease before PCT. Therefore, a negative sentinel node can be a predictor of a negative axilla after PCT and ALND could be abandoned in these patients.…”

Section: Schrenkmentioning

confidence: 99%

“…Patients with a clinically (or sonographically) positive axilla undergo FNA biopsy to verify metastatic disease and then are scheduled to have SNB after PCT. The algorithm in figure 1 shows our approach to SNB in case a PCT is planned [7].…”

Section: Schrenkmentioning

confidence: 99%

Sentinel Node Biopsy in Breast Cancer: Clinical Implication – Standard of Care – Fututre Prospects

Haid

Kühn²,

Goyal

et al. 2009

Breast Care

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“…Such a result would be considered ideal, but is highly unlikely, and thus unreliable. The studies which generated such results involved as few as 11 or 15 biopsies, which is why no reliable conclusions could be drawn on their basis [8,9].…”

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confidence: 99%

Sentinel node biopsy in breast cancer patients undergoing induction chemotherapy should be performed prior to chemotherapy

Piekarski

2017

Nowotwory. Journal of Oncology

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Sentinel node biopsy in breast cancer patients undergoing induction chemotherapy should be performed prior to chemotherapy Janusz PiekarskiPresently, preoperative chemotherapy is administered ever more frequently in breast cancer patients. It is administered in both non-resectable and resectable patients, i.e. those in whose case it is possible to undertake surgical treatment without the use of chemotherapy. Sentinel node biopsy may only be performed in patients classified as cN0. Hence, the dilemma of whether sentinel node biopsy should be performed before or after preoperative chemotherapy applies only to those patients in whom there are no axillary lymph node metastases before the chemotherapy in question (cN0). Even though the question of whether to perform sentinel node biopsy before or after preoperative chemotherapy in cN0 patients still remains open, a number of indicators testifying to the quality of the results obtained, tend to point in favour of sentinel node biopsy performed prior to chemotherapy. When sentinel node biopsy is performed before induction chemotherapy, the node identification rate is higher (100% vs 95%), and the rate of false negative results is lower (7.4% vs 11.4%) than in the case of a post-chemotherapy biopsy. NOWOTWORY J Oncol 2017; 67, 4: 267-269

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Sentinel node mapping performed before preoperative chemotherapy may avoid axillary dissection in breast cancer patients with negative or micrometastatic sentinel nodes

Cited by 27 publications

References 37 publications

Sentinel lymph node biopsy before versus after neoadjuvant chemotherapy for breast cancer

Sentinel lymph node biopsy before versus after neoadjuvant chemotherapy for breast cancer

Sentinel Node Biopsy in Breast Cancer: Clinical Implication – Standard of Care – Fututre Prospects

Sentinel node biopsy in breast cancer patients undergoing induction chemotherapy should be performed prior to chemotherapy

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Sentinel node mapping performed before preoperative chemotherapy may avoid axillary dissection in breast cancer patients with negative or micrometastatic sentinel nodes

Cited by 27 publications

References 37 publications

Sentinel lymph node biopsy before versus after neoadjuvant chemotherapy for breast cancer

Sentinel lymph node biopsy before versus after neoadjuvant chemotherapy for breast cancer

Sentinel Node Biopsy in Breast Cancer: Clinical Implication &ndash; Standard of Care &ndash; Fututre Prospects

Sentinel node biopsy in breast cancer patients undergoing induction chemotherapy should be performed prior to chemotherapy

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Sentinel Node Biopsy in Breast Cancer: Clinical Implication – Standard of Care – Fututre Prospects