Size of micrometastasis and presence of lymphovascular invasion were significantly related to the risk of finding additional positive axillary lymph nodes when the SN contained only micrometastasis.
The small number of patients with occult contralateral cancers may not warrant routine SN mapping in patients scheduled for contralateral reduction mammaplasty.
Axillary lymph node dissection ± sentinel lymph node ± sentinel node biopsy ± breast cancer ± multicentric breast cancer. Schlu Èsselwo Èrter: Sentinel Lymphknoten ± Mammakarzinom ± Multizentrizita Èt ± Axilladissektion. Summary: Background: Multicentric breast cancer is regarded by most authors as a contraindication for sentinel node (SN) biopsy. However, if the SN concept were valid for multicentric carcinoma as it is for unifocal cancer, patients with a negative SN may have the advantage not only of a more accurate lymph node staging but also decreased morbidity resulting from the procedure. The purpose of this study was to evaluate the feasibility and accuracy of SN biopsy in patients with multicentric breast cancer using a subareolar injection technique for SN mapping. Methods: Forty-eight patients (mean age 56.6 years) with multicentric invasive carcinoma of the breast underwent sentinel lymph node mapping using vital blue dye alone (n = 22) or in combination with 99m TC nanocolloid (n = 26) injected under the areola. Removal of SN(s) was followed by axillary dissection of levels I and II in all patients to evaluate the false negative rate. Results: A mean number of 1.8 SNs were identified in 46 of 48 patients (identification rate: 95.8 %). Twenty-five patients had a positive SN, 21 a negative SN. Axillary dissection confirmed the SN to be negative in 20 of 21 patients, whereas one patient revealed positive non-sentinel lymph nodes (false negative rate: 3.8 %). Overall SN biopsy accurately predicted axillary lymph node status in 45 of 46 patients (97.8 %). Conclusions: SN biopsy using a subareolar injection technique accurately staged the axilla in multicentric breast cancer and may become an alternative to complete axillary lymph node dissection in node negative patients with multicentric breast cancer. (Eur. Surg. 2002; 34:288±291) Die Biopsie des leitenden Lymphknotens beim multizentrischen Mammakarzinom Zusammenfassung: Grundlagen: Das multizentrische Mammakarzinom gilt als Kontraindikation fu Èr die Sentinel Lymphknotenbiopsie. Ist das Konzept des leitenden Lymphknotens auch bei diesen Patientinnen anwendbar, ha Ètte dies den Vorteil einer verminderten Morbidita Èt bei zumindest gleich genauem Lymphknotenstagings. Ziel dieser Studie war Mo Èglichkeit und Aussagekraft der SLB beim multizentrischen Mammakarzinom zu untersuchen. Methodik: Bei 48 Patienten (mittleres Alter: 56,6 Jahre) mit multizentrischem Mammakarzinom wurde ein Sentinel Lymphknotenmapping durch subareola Ère Injektion von Vitalblau alleine (n = 22) oder in Kombination mit einem Radiokolloid (n = 26) durchgefu Èhrt. Intraoperativ wurde der leitende Lymphknoten aufgesucht und entfernt, anschlieûend zur Evaluierung der falsch negativen Rate eine Axilladissektion durchgefu Èhrt. Ergebnisse: Bei 46 von 48 Patientinnen (Auffindungsrate 95,8 %) konnten im Mittel 1,8 Sentinel Lymphknoten gefunden werden. Davon waren 25 tumorbefallen, 21 waren tumorfrei. Die Aufarbeitung des Axilladissektates besta Ètigte die Tumorfreiheit des leitenden Lymphknot...
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