Sentinel node navigation surgery in cervical cancer: a systematic review and metaanalysis

Chiyoda, Tatsuyuki; Yoshihara, Kosuke; Kagabu, Masahiro; Nagase, Satoru; Katabuchi, Hidetaka; Mikami, Mikio; Tabata, Tsutomu; Hirashima, Yasuyuki; Kobayashi, Yoichi; Kaneuchi, Masanori; Tokunaga, Hideki; Baba, Tsukasa

doi:10.1007/s10147-022-02178-w

Cited by 14 publications

(9 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although it was not analyzed in the present study, a meta-analysis on disease-free survival and other oncological outcomes was recently conducted by Parpinel et al, disclosing no differences in survival and 5-year disease-free survival between SLN mapping and pelvic lymphadenectomy [38]. Regarding the safety of the technique, a recent review from Chiyoda et al found out that sentinel lymph node navigation surgery with Technetium (with or without blue dye) or ICG was safe in SLN assessment (reducing surgical complications and improving SLN detection), but without relevant information regarding the long-term safety of SLN harvest [39]. Adequately detecting the three types of metastases (MAC-MIC-ITCs) is of importance since MICs and MACs have clinical impacts (but the prognostic impact of ITCs remains unclear), as a recent meta-analysis disclosed [35].…”

Section: Discussionmentioning

confidence: 99%

Predictors of Non-Sentinel Lymph Node Metastasis in Patients with Positive Sentinel Lymph Node in Early-Stage Cervical Cancer: A SENTICOL GROUP Study

Pache,

Tantari,

Guani

et al. 2023

Cancers

View full text Add to dashboard Cite

Background: The goal of this study was to identify the risk factors for metastasis in the remaining non-sentinel lymph nodes (SLN) in the case of positive SLN in early-stage cervical cancer. Methods: An ancillary analysis of two prospective multicentric databases on SLN biopsy for cervical cancer (SENTICOL I and II) was performed. Patients with early-stage cervical cancer (FIGO 2018 IA to IIA1), with bilateral SLN detection and at least one positive SLN after ultrastaging, were included. Results: 405 patients were included in SENTICOL I and Il. Fifty-two patients had bilateral SLN detection and were found to have SLN metastasis. After pelvic lymphadenectomy, metastatic involvement of non-SLN was diagnosed in 7 patients (13.5%). Patients with metastatic non-SLN were older (51.9 vs. 40.8 years, p = 0.01), had more often lympho-vascular space invasion (LVSI) (85.7% vs. 35.6%, p = 0.03), and had more often parametrial involvement (42.9% vs. 6.7%, p = 0.003). Multivariate analysis retained age (OR = 1.16, 95% IC = [1.01–1.32], p = 0.03) and LVSI (OR = 25.97, 95% IC = [1.16–582.1], p = 0.04) as independently associated with non-SLN involvement. Conclusions: Age and LVSI seemed to be predictive of non-SLN metastasis in patients with SLN metastasis in early-stage cervical cancer. Larger cohorts are needed to confirm the results and clinical usefulness of such findings.

show abstract

Section: Discussionmentioning

confidence: 99%

Predictors of Non-Sentinel Lymph Node Metastasis in Patients with Positive Sentinel Lymph Node in Early-Stage Cervical Cancer: A SENTICOL GROUP Study

Pache,

Tantari,

Guani

et al. 2023

Cancers

View full text Add to dashboard Cite

show abstract

“…Although lymph node involvement in para-aortic site deteriorated the outcomes of cervical cancer patients, the benefit of para-aortic lymph nodes dissection needed further validation (Cho et al 2020 ). Owing to the potential complications of lymph node resection, SLN biopsy or selective lymph node dissection was possibly considered as one of the standard therapies for early cervical cancer (Chiyoda et al 2022 ; Niu et al 2022 ; Poddar and Maheshwari 2021 ). Consequently, understanding the pattern of LNM contributed to performing lymph node related surgery.…”

Section: Discussionmentioning

confidence: 99%

The distribution pattern of pelvic lymph nodal metastases in cervical cancer

Xie

Zhao

Wang

et al. 2023

J Cancer Res Clin Oncol

View full text Add to dashboard Cite

Purpose Depiction of pelvic lymph node metastasis (LNM) sites among patients with cervical cancer facilitates accurate determination of the extent of dissection and radiotherapy regimens. Methods A retrospective study of 1182 cervical cancer patients who underwent radical hysterectomy and pelvic lymph node dissection between 2008 and 2018 was performed. The number of removed pelvic lymph nodes and metastasis status in different anatomical regions was analyzed. The prognostic difference of patients with lymph node involvement stratified by various factors was analyzed by Kaplan–Meier method. Results The median number of pelvic lymph nodes detected was 22, mainly from obturator (29.54%) and inguinal (21.14%) sites. Metastatic pelvic lymph nodes were found in 192 patients, with obturator accounting for the highest percentage (42.86%). The patients with lymph node involvement in single site had better prognosis that those in multiple sites. The overall- (P = 0.021) (OS) and progression-free (P < 0.001) survival (PFS) curves of patients with inguinal lymph node metastases were worse compared to those with obturator site. There was no difference in the OS and PFS among patients with 2 and more than 2 lymph nodes involvement. Conclusion An explicit map of LNM in patients with cervical cancer was presented in this study. Obturator lymph nodes tended to be involved. The prognosis of patients with inguinal lymph node involvement was poor in contrast to that with obturator LNM. In patients with inguinal lymph node metastases, clinical staging needs to be reconsidered and extended radiotherapy to the inguinal region needs to be strengthened.

show abstract

“…Cervical cancer is one of the most common malignant tumors that threatens women’s health worldwide. Surgery remains one of the main treatment methods [ 1 ]. Patients with cervical cancer have to face the specific adverse effects of the cancer and surgical treatment that are not found in other cancers, which might lead to a negative impact on supportive care needs [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Development of a supportive care needs eHealth application for patients with cervical cancer undergoing surgery: a feasibility study

Song,

Xia,

et al. 2024

BMC Health Serv Res

View full text Add to dashboard Cite

Purpose To inform the development of an eHealth application for patients with cervical cancer for monitoring supportive care needs, perceived care supply and quality of life. Methods A mixed-method design was used. The 19-month process involved five phases: (1) a literature review to screen the components of applications, (2) a cross-sectional needs assessment for patients with cervical cancer to define the needs and application program frame, (3) expert consultation to refine the draft, (4) software development, and (5) pilot testing and user comment collection. Patients in the intervention group received a 7-day application intervention combined with usual care. Supportive care needs, perceived care supply, quality of life and user’s additional comments were collected. Results The literature review results in phase 1 revealed the importance of full preparation, especially a supportive care needs assessment, before application development. Subsequent supportive care needs investigation in phase 2 revealed that the most urgent needs were informational needs and privacy protection. In phase 3, 43 expert recommendations for application improvement were refined. The new application contained the patient and the health care professional portal in phase 4. Then, on Day 7, there existed score changes of the outcome measures in both intervention and control group. Users had a positive experience with the application. Conclusions This study demonstrates the feasibility of applications targeting access to supportive care, which may be effective for improving the outcome measures but needed to be evaluated in future studies.

show abstract

Sentinel node navigation surgery in cervical cancer: a systematic review and metaanalysis

Cited by 14 publications

References 56 publications

Predictors of Non-Sentinel Lymph Node Metastasis in Patients with Positive Sentinel Lymph Node in Early-Stage Cervical Cancer: A SENTICOL GROUP Study

Predictors of Non-Sentinel Lymph Node Metastasis in Patients with Positive Sentinel Lymph Node in Early-Stage Cervical Cancer: A SENTICOL GROUP Study

The distribution pattern of pelvic lymph nodal metastases in cervical cancer

Development of a supportive care needs eHealth application for patients with cervical cancer undergoing surgery: a feasibility study

Contact Info

Product

Resources

About