Seoul Neuropsychological Screening Battery-Dementia Version (SNSB-D): A Useful Tool for Assessing and Monitoring Cognitive Impairments in Dementia Patients

Abstract

The Seoul Neuropsychological Screening Battery (SNSB) is one of the standardized neuropsychological test batteries widely used in Korea. However, it may be a bit too lengthy for patients with decreased attention span; and it does not provide the score of global cognitive function (GCF), which is useful for monitoring patients longitudinally. We sought to validate a dementia version of SNSB (SNSB-D) that was shorter than the original SNSB and contained only scorable tests with a GCF score of 300. We administered SNSB-D to patients with mild cognitive impairment (MCI) (n=43) and Alzheimer's disease (AD) (n=93), and normal controls (NC) (n=77). MCI and AD groups had GCF scores significantly different from NC group, and GCF scores were able to distinguish patients with Clinical Dementia Rating of 0.5 and 1. Test-retest reliability was high, with a correlation coefficient of 0.918 for AD, 0.999 for MCI, and 0.960 for NC. The GCF score significantly correlated with the Mini-Mental State Examination (MMSE). Through ROC-curve analysis, GCF scores were found to yield more accurate diagnoses than the MMSE. The SNSB-D is a valid, reliable tool for assessing the overall cognitive function, and can be used to monitor cognitive changes in patients with dementia.

The Clinical Characteristics according to the Educational Level in the Elderly Patients with Mild Alzheimer's Disease Dementia

“…We selected these tests because the z-scores of the tests are delicately defined, and are thought to be less affected by illiteracy. Norms according to age, gender, and educational level were based on the data obtained from 447 normal subjects in SNSB-I, 9 which have been updated in SNSB-II incorporating normal data from 1100 individuals (http://www.humanbrainkorea.com/Item/Default.aspx?sub=SNSB_2). The raw scores were converted to z-scores based on the means of the individual groups, which are determined by the difference in age, gender, and educational level.…”

Correlation of the Neuropsychological Screening Battery (NSB) and Neuroanatomy for the Parkinson's Disease with Mild Cognitive Impairment by Using the Analysis of Cerebral Cortex Thickness in the Brain MRI

“…(magnetic resonance image. MRI) 검사를 추가적으로 시 행하고 있다 [8], [9] . 그러나 초기 파킨슨병 환자의 23%가 경도인지장애를 동반하며 경도인지장애를 동반한 파 킨슨병 환자가 그렇지 않은 환자에 비하여 치매로의 이행률이 높기 때문에 실체에 대한 명확한 정의 확립 이 어려움에도 불구하고 경도인지장애에 대한 진단적 기준 마련이 시급하다 [10], [11] .…”

Identification of a novel nonsense mutation in the rod domain of GFAP that is associated with Alexander disease

“…He scored 26/30 on a Mini-Mental Status Examination (MMSE), and a comprehensive neuropsychological test 14 revealed deficits in his visual immediate and recent memory, naming and word fluency, along with mild depression. However, his daily living activities were normal.…”