Seoul Virus Infection in Humans, France, 2014–2016

Reynes, Jean-Marc; Carli, Damien; Bour, Jean-Baptiste; Boudjeltia, Samir; Dewilde, A.; Gerbier, Guillaume; Nussbaumer, Timothée; Jacomo, Véronique; Rapt, Marie-Pierre; Rollin, Pierre E.; Septfons, Alexandra

doi:10.3201/eid2306.160927

Cited by 35 publications

(56 citation statements)

References 13 publications

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“…SEOV is responsible for a milder form of HFRS as compared to the disease caused by HTNV, with a case‐fatality rate less than 1% . However, some SEOV‐associated HFRS human cases still need hospitalization . The transmission of SEOV to humans usually occurs through direct contact with infected rodents.…”

Section: Discussionmentioning

confidence: 99%

“…Most cases were occupational exposure related and confirmed by specific anti‐SEOV IgG detection. In addition, acute human SEOV infections in France have been reported by detecting SEOV‐specific IgM and viral RNA (from lineages #7 and #9) . In US, SEOV has been detected in city rats in New York .…”

Section: Discussionmentioning

confidence: 99%

“…It is thought that SEOV originated in China, and was subsequently exported to Europe and later spread through the New World following human migrations and sea‐trade . In Europe, SEOV has been found in wild rats in the UK, France, and Belgium, and in pet rats in France, Sweden, and UK . SEOV is causing HFRS, which is generally somewhat milder than the disease caused by HTNV, but more severe than Puumala virus (PUUV) infection .…”

Section: Introductionmentioning

confidence: 99%

“…A recent imported human case of SEOV infection has been reported in Germany . HFRS cases in laboratory workers in Belgium, the Netherlands, UK, and France have been recorded, and human SEOV cases have been found in the UK and France …”

Section: Introductionmentioning

confidence: 99%

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Genetic analyses of Seoul hantavirus genome recovered from rats (Rattus norvegicus) in the Netherlands unveils diverse routes of spread into Europe

Ling

Verner-Carlsson

Eriksson

et al. 2019

Journal of Medical Virology

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Seoul virus (SEOV) is the etiologic agent of hemorrhagic fever with renal syndrome. It is carried by brown rats (Rattus norvegicus), a commensal rodent that closely cohabitates with humans in urban environments. SEOV has a worldwide distribution, and in Europe, it has been found in rats in UK, France, Sweden, and Belgium, and human cases of SEOV infection have been reported in Germany, UK, France, and Belgium. In the search of hantaviruses in brown rats from the Netherlands, we found both serological and genetic evidence for the presence of SEOV in the local wild rat population. To further decipher the relationship with other SEOV variants globally, the complete genome of SEOV in the Netherlands was recovered. SEOV sequences obtained from three positive rats (captured at close trapping locations at the same time) were found highly similar. Phylogenetic analyses demonstrated that two lineages of SEOV circulate in Europe. Strains from the Netherlands and UK, together with the Baxter strain from US, constitute one of these two, while the second includes strains from Europe and Asia. Our results support a hypothesis of diverse routes of SEOV spread into Europe. These findings, combined with other indications on the expansion of the spatial European range of SEOV, suggest an increased risk of this virus for the public health, highlighting the need for increased surveillance.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Genetic analyses of Seoul hantavirus genome recovered from rats (Rattus norvegicus) in the Netherlands unveils diverse routes of spread into Europe

Ling

Verner-Carlsson

Eriksson

et al. 2019

Journal of Medical Virology

View full text Add to dashboard Cite

show abstract

“…In Europe, molecular analysis has shown circulation of SEOV in wild brown rats ( Rattus norvegicus ) and in pet rats in the United Kingdom, France, Belgium, the Netherlands, and Sweden; however, human SEOV infections have been diagnosed by using only serologic analysis ( 4 ). Unequivocal molecular proof of human SEOV infections in Europe has been shown only for 4 patients in France ( 5 ) and 1 patient in the United Kingdom (https://www.gov.uk/government/publications/hantavirus-infection-in-people-sero-surveillance-study-in-england). …”

mentioning

confidence: 99%