Separate screening of brominated and chlorinated dioxins in field samples using in vitro reporter gene assays with rat and mouse hepatoma cell lines

Suzuki, Go; Nakamura, Masafumi; Michinaka, Chieko; Tue, Nguyen Minh; Handa, Hiroshi; Takigami, Hidetaka

doi:10.1016/j.aca.2017.04.024

Cited by 6 publications

(2 citation statements)

References 49 publications

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“…Dust is also a source of persistent organic pollutants, including flame retardants, and dust has been used as proxy for human exposure. Dioxin-like chemicals and the AhR activation were the focus of many studies on dust (Tue et al, 2013;Suzuki et al, 2017) but also inflammation (Allermann and Poulsen, 2000) and endocrine effects (Chou et al, 2015).…”

Section: Particles In Air and Dustmentioning

confidence: 99%

Bioanalytical Tools in Water Quality Assessment

Neale¹,

Leusch²,

Escher³

2021

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The first edition of Bioanalytical Tools in Water Quality Assessment was released in 2012. The field has exploded since and the second edition updates and reviews the application of bioanalytical tools for water quality assessment including surveillance monitoring. The book focuses on applications to water quality assessment ranging from wastewater to drinking water, including recycled water, as well as treatment processes and advanced water treatment. Emerging applications for other environmental matrices are also included. Bioanalytical Tools in Water Quality Assessment, Second Edition, not only demonstrates applications but also fills in the background knowledge in toxicology/ecotoxicology needed to appreciate these applications. Each chapter summarises fundamental material in a targeted way so that information can be applied to better understand the use of bioanalytical tools in water quality assessment. The book can be used by lecturers teaching academic and professional courses and also by risk assessors, regulators, experts, consultants, researchers and managers working in the water sector. It can also be a reference manual for environmental engineers, analytical chemists and toxicologists. ISBN: 9781789061970 (Paperback) ISBN: 9781789061987 (eBook)

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Section: Particles In Air and Dustmentioning

confidence: 99%

Bioanalytical Tools in Water Quality Assessment

Neale¹,

Leusch²,

Escher³

2021

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“…DLCs. For the detection of individual chlorinated and brominated dioxins in crude extract, a process involving a silica gel impregnated with 55% sulfuric acid (clean-up column) and a silica gel impregnated with 10% silver nitrate (fractionation column) packed into glass columns (Fujifilm Wako Pure Chemical Co., Osaka, Japan) combined with the DR-CALUX assay was used as previously reported 27 but with modifications. Samples of the crude extract were prepared for the DR-CALUX assay, as described in the Supporting Information.…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

Emission of Dioxin-like Compounds and Flame Retardants from Commercial Facilities Handling Deca-BDE and Their Downstream Sewage Treatment Plants

Suzuki

Matsukami

Michinaka

et al. 2021

Environ. Sci. Technol.

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Commercial mixtures of decabromodiphenyl ether (deca-BDE), a brominated flame retardant, contain not only polybrominated diphenyl ethers (PBDEs, mainly BDE-209) as the main component but also dioxin-like compounds (DLCs) such as polybrominated dibenzofurans (PBDFs). Deca-BDE handling facilities (DHFs) and sewage treatment plants receiving effluent from DHFs are point sources of DLC and flame retardant (FR) pollution. Here, we examined their emission in Japan. For DHF effluents, DLCs detected by the dioxin-responsive chemically activated luciferase expression (DR-CALUX) assay were 1.3−890 pg TCDD-EQ/L (median 46 pg TCDD-EQ/L), while PBDEs and other FRs were <2.0−110,000 ng/L (610 ng/L) and 150− 4,800,000 ng/L (41,000 ng/L). Risk quotients based on predicted no-effect concentrations suggested that DLCs, decabromodiphenyl ethane (DBDPE), tris(2,3-dibromopropyl) isocyanurate (TDBP-TAZTO), and bisphenol A bis(diphenyl phosphate) (BPA-BDPP) present significant risks for aquatic organisms. The concentrations of PBDFs, which are impurities in deca-BDE, were expected to decrease with the inclusion of deca-BDE in the Stockholm Convention list of persistent organic pollutants (May 2017). However, DLCs other than PBDFs and alternative FRs such as DBDPE, TDBP-TAZTO, and BPA-BDPP are likely still discharged. Additional findings indicate that strong (e.g., DLCs, DBDPE, and BPA-BDPP), but not weak (e.g., TDBP-TAZTO), hydrophobic compounds are sufficiently removed by current wastewater treatment processes in Japan.

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