The efficient use of water and N represents a primary concern to agricultural production in Northwest China. The objective of this study was to assess the impacts of irrigation and fertilization on water and N use, soil volatilized NH 3 , soil NO 3 leaching, and NO 3 transfer in soil profiles. A 2-yr field experiment was conducted to assess the separation of N fertilizer and water with alternating furrow irrigation (SNWAFI) and conventional irrigation and fertilization (CIF) in a maize (Zea mays L.) production system. The yields with SNWAFI were 10 to 16% greater than with CIF. Compared with CIF, SNWAFI increased water use efficiencies (WUEs) by 13 to 33%, agronomic efficiency of fertilizer N by 36 to 56%, and NO 3 --N in the upper soil layers (0-60 cm) by 30 to 60%. However, SNWAFI reduced NO 3 --N in the deeper soil layers (60-200 cm) by 8 to 44% compared with CIF. The use of SNWAFI also decreased soil NH 3 emission with the combination with lower irrigation (40 mm) and N rate (100 kg N ha -1 ), which indicated that SNWAFI emitted less soil NH 3 than CIF. Therefore, compared with CIF, SNWAFI increased maize yield WUE and N use efficiency, reduced N leaching, and curtailed soil NH 3 loss with appropriate irrigation and N rates. The use of SNWAFI, leading to better spatial management of irrigation water and N application, can provide both agronomic and environmental benefits.