Separation of A- versus C-nociceptive inputs into spinal–brainstem circuits

Parry, DM; MacMillan, F; Koutsikou, Stella; McMullan, Simon; Lumb, Bridget M.

doi:10.1016/j.neuroscience.2008.01.018

Cited by 20 publications

(18 citation statements)

References 46 publications

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“…Animal studies have identified a rostral‐cephalic somatotrophic organization of inputs into the individual segments of the PAG, this may explain the pattern of segmentation observed. [Bandler et al, 2000; Keay and Bandler, 2001, 2002; Parry et al, 2008]. …”

Section: Discussionmentioning

confidence: 99%

Connectivity‐based segmentation of the periaqueductal gray matter in human with brainstem optimized diffusion MRI

Ezra

Faull

Jbabdi

et al. 2015

Human Brain Mapping

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The periaqueductal gray matter (PAG) is a midbrain structure, involved in key homeostatic neurobiological functions, such as pain modulation and cardiorespiratory control. Animal research has identified four subdivisional columns that differ in both connectivity and function. Until now these findings have not been replicated in humans. This study used high‐resolution brainstem optimized diffusion magnetic resonance imaging and probabilistic tractography to segment the human PAG into four subdivisions, based on voxel connectivity profiles. We identified four distinct subdivisions demonstrating high spatial concordance with the columns of the animal model. The resolution of these subdivisions for individual subjects permitted detailed examination of their structural connectivity without the requirement of an a priori starting location. Interestingly patterns of forebrain connectivity appear to be different to those found in nonhuman studies, whereas midbrain and hindbrain connectivity appears to be maintained. Although there are similarities in the columnar structure of the PAG subdivisions between humans and nonhuman animals, there appears to be different patterns of cortical connectivity. This suggests that the functional organization of the PAG may be different between species, and as a consequence, functional studies in nonhumans may not be directly translatable to humans. This highlights the need for focused functional studies in humans. Hum Brain Mapp 36:3459–3471, 2015. © 2015 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc.

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Section: Discussionmentioning

confidence: 99%

Connectivity‐based segmentation of the periaqueductal gray matter in human with brainstem optimized diffusion MRI

Ezra

Faull

Jbabdi

et al. 2015

Human Brain Mapping

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“…In contrast, the ventrolateral column receives convergent input from both the superficial and deep dorsal horn relaying nociceptive afferent information from visceral, muscle, and C-fiber skin nociceptors as well as visceral inputs from the nucleus of the NTS and sacral spinal cord. Functional neuroimaging studies in humans indicate that PAG activation by nociceptive inputs is modulated by attention, emotion, expectation of pain and expectation-related placebo analgesia [54][55][56][57][58][59][60][61]. Experimental studies using chemical microstimulation indicate that the different columns of the PAG organize different coping strategies to pain and other stressors [62][63][64][65][66].…”

Section: Descending Pain Modulatory Systemmentioning

confidence: 99%

Nociception and autonomic nervous system

et al. 2013

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The International Association for the Study of Pain (IASP) defines pain as ''an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage''. Pain may also be experienced in absence of noxious stimuli and together with temperature and other bodily feelings constitute the interoception redefined as the sense of the physiological condition of the entire body, not just the viscera. The main characteristic of these feelings is the affective aspect. Emotion, motivation, and consequent behavior connected with these feelings characterize their homeostatic role. This implies an interaction between neural structures involved in pain sensation and autonomic control. The aim of this review is to focus on pain perception, mainly on pain matrix structures' connections with the autonomic nervous system.

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“…These 2 different types of pain are subserved by different sensitive modalities and pathways. Adelta‐ and C‐fiber nociceptors convey different qualities of the pain signal: first (pricking, well localized) and second (burning, diffuse) pain, respectively 45 . Escapable pain results typically from the activation of sensory A‐delta fibers, that originate especially from the skin and transmit cutaneous pain, whereas inescapable pain from the activation of C fibers mainly from the deep viscera, that subserve visceral homeostatic pain 46‐49 .…”

Section: The Behavioral Meaning Of Pain: Cutaneous/escapable Vs Viscementioning

confidence: 99%

The Primary Headaches as a Reflection of Genetic Darwinian Adaptive Behavioral Responses

Montagna¹,

Pierangeli²,

Cortelli³

2010

Headache

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These different behavioral responses are thus specific to different kinds of pain, distinguished by the behavioral significance of the pain (visceral pain in migraine vs exteroceptive pain in CH), and imply brain matrices involving different networks in the brainstem, hypothalamus, and forebrain regions that engender evolutionarily conserved adaptive genetic responses. Cytokines play an important role in their development. Predictions and limitations of the hypothesis are discussed together with implications for genetic studies on headaches.

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Separation of A- versus C-nociceptive inputs into spinal–brainstem circuits

Cited by 20 publications

References 46 publications

Connectivity‐based segmentation of the periaqueductal gray matter in human with brainstem optimized diffusion MRI

Connectivity‐based segmentation of the periaqueductal gray matter in human with brainstem optimized diffusion MRI

Nociception and autonomic nervous system

The Primary Headaches as a Reflection of Genetic Darwinian Adaptive Behavioral Responses

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