Separation of Active and Toxic Portions in Sambucus ebulus

Ebrahimzadeh, Mohammad Ali; Mahmoudi, Maryam Tayefeh; Karami, Mohammad; Saeedi, Soheil; Ahmadi, Amirhossein; Salimi, Elika

doi:10.3923/pjbs.2007.4171.4173

Cited by 35 publications

(16 citation statements)

References 8 publications

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“…46 This property, which is correlated with its total flavonoid content, could be another explanation for its anti-inflammatory effect. 47, 48 An animal study in rats revealed that methanol and n-hexane extract of S ebulus have a considerable inhibitory effect on carrageenan-induced paw edema in comparison with diclofenac. 48 Analgesic Effect.…”

Section: Sambucus Ebulus In Biomedical Researches Preclinical Studiesmentioning

confidence: 99%

“…47, 48 An animal study in rats revealed that methanol and n-hexane extract of S ebulus have a considerable inhibitory effect on carrageenan-induced paw edema in comparison with diclofenac. 48 Analgesic Effect. There has, of course, been conducted yet another study indicating the significant antinociceptive effect of S ebulus in rats.…”

Section: Sambucus Ebulus In Biomedical Researches Preclinical Studiesmentioning

confidence: 99%

“…71,72 Still, no state of being venomous has been reported after 2 mg/kg intraperitoneal injection in this model. 48 Lethal dose 50% (LD 50 ) of its rhizome methanol extract is 600 mg/kg. 18…”

Section: Toxicity and Side Effectsmentioning

confidence: 99%

Section: Sambucus Ebulus In Biomedical Researchesmentioning

confidence: 99%

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Biological Effects and Clinical Applications of Dwarf Elder (Sambucus ebulus L): A Review

Jabbari

Daneshfard

Emtiazy

et al. 2017

J Evid Based Complementary Altern Med

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Dwarf elder (Sambucus ebulus L) is one of the best known medicinal herbs since ancient times. In view of its benefits as a widely applicable phytomedicine, it is still used in folk medicine of different parts of the world. In addition to its nutritional values, dwarf elder contains different phytochemicals among which flavonoids and lectins are responsible for most of its therapeutic effects. Dwarf elder has been used for different ailments including: joint pains, cold, wounds, and infections. Nevertheless, recent evidence has revealed its potentials for making attempts at treating cancer and metabolic disorders. This review aimed to provide a comprehensive description of dwarf elder regarding its traditional uses and modern findings which may contribute to the development of novel natural-based therapeutic agents.

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Section: Sambucus Ebulus In Biomedical Researches Preclinical Studiesmentioning

confidence: 99%

Section: Sambucus Ebulus In Biomedical Researches Preclinical Studiesmentioning

confidence: 99%

Section: Toxicity and Side Effectsmentioning

confidence: 99%

Section: Sambucus Ebulus In Biomedical Researchesmentioning

confidence: 99%

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Biological Effects and Clinical Applications of Dwarf Elder (Sambucus ebulus L): A Review

Jabbari

Daneshfard

Emtiazy

et al. 2017

J Evid Based Complementary Altern Med

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“…Nutritional compounds of the plant are attributed to its minerals, fibers, vitamins, and sugars. Sambucus species are also rich with important secondary metabolites such as anthocyanin, flavonoids, polyphenols, triterpenes, tannins, and lectins, most of which have medicinal values, including antioxidant, anti-inflammatory, analgesic, antimicrobial, anticancer, neuroprotective, and antidepressant activities [15][16][17][18][19]. Quercetin, a polyphenolic compound, can inhibit tumor growth through induction of apoptosis in a variety of cancer cell lines [20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Evaluating Cytotoxic Potential of the Fruit and the Leaf Extracts of Sambucus ebulus (L.) on MCF7 and AGs Cell Lines

2021

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Background: Breast and stomach cancers are the most common malignancies in Iranian females and males, respectively. Enriching with phytochemicals that have antioxidant and cytotoxic activities, extracts from dwarf elder (Sambucus ebulus L.) holds promises to be used for alternative medication. Materials and Methods: We investigated the cytotoxic and antiproliferative activities of the leaf and the fruit ethyl-acetate (EA), as well as the methanolic (MeOH) extracts of dwarf elder upon treatment of the MCF-7 and AGS cells. Twenty-seven concentration series ranging from 10 to 2000 μg/mL were administered to the cells, and their growth inhibitory potential was assessed using MTT assay. The potential anticancer compounds of the extracts were quantified applying an improved highperformance liquid chromatography (HPLC). Results: All extracts showed positive dose-dependent cytotoxic activities on both cell lines. The EA extracts demonstrated more cytotoxicity compared to those of the MeOH ones (P<0.0001). The leaf EA extract showed IC50 values of 65 and 50 μg/mL, while those of the fruit were estimated as 58 and 50 μg/mL on the MCF-7 and AGS cells, respectively. The AGS cell line showed more susceptibility to all extracts tested compared to the MCF-7. MeOH extracts caused only a maximum of ~20% reduction in cell viability at 2000 μg/mL concentration. According to the HPLC analysis, leaf extracts contained phenolic compounds, including p- coumaric acid (0.10 mg per g powder), rutin (0.07 mg per g powder), and quercetin (0.02 mg per g powder). Conclusion: EA extract of the fruit shows the highest cytotoxicity: reducing 35.3% viability of the AGS cells with 10 μg/mL concentration. It can be considered a potential chemopreventive agent for cancer therapies. However, MeOH extracts with far low cytotoxicity or non-cytotoxic at some concentrations would be an appropriate candidate for preventing tumor growth without affecting neighboring normal cells.

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Elderberry: Botany, Horticulture, Potential

Charlebois

Byers

Finn

et al. 2010

Horticultural Reviews, Volume 37

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Kanadese vlier sabugueiro do Canada sauco del Canada Sambucus canadensis American elder(berry), bourtree, Canada elder, eastern elderberry, elderberry, common elder, sweet elder, pie elder, elder-blow, blackberry elder, Mexican elder sureau blanc, sureau du Canada, sirop blanc D. CHARLEBOIS, P. 1. BYERS, C. E. FINN, AND A. 1. THOMAS almindelig hyld Flieder, memeine Holunder, Holunder, schwarzer Flieder, schwarzer Holunder fekete bodza sambuco, sambuco nero, sambuco nostrale, zambuco, zambuco arboreo bez czarny sabugueiro, sabugueiro negro, sabugueiro preto 4epeH 6b3

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Separation of Active and Toxic Portions in Sambucus ebulus

Cited by 35 publications

References 8 publications

Biological Effects and Clinical Applications of Dwarf Elder (Sambucus ebulus L): A Review

Biological Effects and Clinical Applications of Dwarf Elder (Sambucus ebulus L): A Review

Evaluating Cytotoxic Potential of the Fruit and the Leaf Extracts of Sambucus ebulus (L.) on MCF7 and AGs Cell Lines

Elderberry: Botany, Horticulture, Potential

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