Separation of Five Iridoid Glycosides from Lonicerae Japonicae Flos Using High-Speed Counter-Current Chromatography and Their Anti-Inflammatory and Antibacterial Activities

Yang, Ran; Fang, Lei; Li, Jia; Zhao, Zhenying; Zhang, Hua; Yong-qing, Zhang

doi:10.3390/molecules24010197

Cited by 19 publications

(12 citation statements)

References 18 publications

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“…In several regions of China, the former three are commonly used as foods. Several studies indicated that these four plants have anti-obesity or liver protection properties (6)(7)(8)(9)(10)12,13). Thus, we proposed that YZH may be a promising strategy for NAFLD management.…”

Section: Original Articlementioning

confidence: 94%

Yin Zhi Huang, a traditional Chinese herbal formula, ameliorates diet-induced obesity and hepatic steatosis by activating the AMPK/SREBP-1 and the AMPK/ACC/CPT1A pathways

Yao

Cheng

et al. 2020

Ann Transl Med

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Background: Yin Zhi Huang (YZH) is a formula composed of Artemisia scoparia, Gardeniae fructus, Scutellaria baicalensis Georgi, and Lonicerae Japonicae Flos. Most of the components are eaten as food in Asia. Here, we evaluated the role of YZH on a high-fat diet (HFD)-induced obesity and hepatic steatosis.Methods: Male C57BL/6J mice were fed with normal-chow diet, HFD, and HFD with low-or high-dose YZH for 16 weeks. Body weight gain, adipose mass, and plasma lipids levels were measured to evaluate the effect of YZH on obesity. Liver weight and staining methods on liver tissues were used to determine hepatic steatosis. The expression of involved genes and proteins were screened with qRT-PCR and immunoblotting, respectively. Results:The results showed that YZH significantly reduced body weight gain, adipose mass, and the size of adipocytes, while did not affect food intake in HFD-fed mice. H&E staining, bodipy staining, and oil red O staining displayed that YZH alleviates hepatic lipid accumulation. It also effectively restored elevated plasma levels of triglycerides (TG), total cholesterol (TC), alanine aminotransferase, and aspartate aminotransferase in HFD-fed mice. Mechanistically, these effects of YZH have associated with a decrease of AMPK/SREBP-1 pathway-mediated de novo lipogenesis and an increase of AMPK/ACC/CPT1A pathwaymediated mitochondrial fatty acid β oxidation.Conclusions: YZH supplementation ameliorated diet-induced obesity and hepatic steatosis by decreasing AMPK/SREBP-1 pathway-mediated de novo lipogenesis and increasing AMPK/ACC/CPT1A pathwaymediated mitochondrial fatty acid β oxidation.

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Section: Original Articlementioning

confidence: 94%

Yin Zhi Huang, a traditional Chinese herbal formula, ameliorates diet-induced obesity and hepatic steatosis by activating the AMPK/SREBP-1 and the AMPK/ACC/CPT1A pathways

Yao

Cheng

et al. 2020

Ann Transl Med

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“…Moreover, iridoid glycosides are responsible for antibacterial 12 , anti-allergic 13 , hepatoprotective 14 , and other pharmacological properties. Iridoid possess neuroprotective 15 , anti-thrombotic, and anti-inflammatory effects 16 . The accumulation and synthesis of bioactive constituents mainly depend on satisfactory growing conditions.…”

Section: Introductionmentioning

confidence: 99%

Variations in morphology, physiology, and multiple bioactive constituents of Lonicerae Japonicae Flos under salt stress

Cai

Liu

Chen

et al. 2021

Sci Rep

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Lonicerae Japonicae Flos (LJF) is an important traditional Chinese medicine for the treatment of various ailments and plays a vital role in improving global human health. However, as unable to escape from adversity, the quality of sessile organisms is dramatically affected by salt stress. To systematically explore the quality formation of LJF in morphology, physiology, and bioactive constituents' response to multiple levels of salt stress, UFLC-QTRAP-MS/MS and multivariate statistical analysis were performed. Lonicera japonica Thunb. was planted in pots and placed in the field, then harvested after 35 days under salt stress. Indexes of growth, photosynthetic pigments, osmolytes, lipid peroxidation, and antioxidant enzymes were identified to evaluate the salt tolerance in LJF under different salt stresses (0, 100, 200, and 300 mM NaCl). Then, the total accumulation and dynamic variation of 47 bioactive constituents were quantitated. Finally, Partial least squares discrimination analysis and gray relational analysis were performed to systematically cluster, distinguish, and evaluate the samples, respectively. The results showed that 100 mM NaCl induced growth, photosynthetic, antioxidant activities, osmolytes, lipid peroxidation, and multiple bioactive constituents in LJF, which possessed the best quality. Additionally, a positive correlation was found between the accumulation of phenolic acids with antioxidant enzyme activity under salt stress, further confirming that phenolic acids could reduce oxidative damage. This study provides insight into the quality formation and valuable information to improve the LJF medicinal value under salt stress.

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“…Some species of this genus can also be used in functional foods, cosmetics and other applications, such as Lonicerae japonica Thunb. [ 7 ]. L. japonica Thunb., as a kind of traditional Chinese medicine for both medicine and food, can be used to make herbal tea and toothpaste and so on.…”

Section: Introductionmentioning

confidence: 99%

A Review: The Triterpenoid Saponins and Biological Activities of Lonicera Linn.

Fang

Yang

et al. 2020

Molecules

Self Cite

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Lonicera Linn. is an important genus of the family Caprifoliaceae comprising of approximately 200 species, and some species of which have been usually used in traditional Chinese medicine for thousands of years. Some species of this genus can also be used in functional foods, cosmetics and other applications. The saponins, as one of most important bioactive components of the Lonicera Linn. genus, have attracted the attention of the scientific community. Thus, a comprehensive and systematic review on saponins from the genus is indispensable. In this review, 87 saponins and sapogenin from the genus of Lonicera Linn., together with their pharmacological activities including hepatoprotective, anti-inflammatory, anti-bacterial, anti-allergic, anti-tumor, and immunomodulatory effects, and hemolytic toxicity were summarized.

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Separation of Five Iridoid Glycosides from Lonicerae Japonicae Flos Using High-Speed Counter-Current Chromatography and Their Anti-Inflammatory and Antibacterial Activities

Cited by 19 publications

References 18 publications

Yin Zhi Huang, a traditional Chinese herbal formula, ameliorates diet-induced obesity and hepatic steatosis by activating the AMPK/SREBP-1 and the AMPK/ACC/CPT1A pathways

Yin Zhi Huang, a traditional Chinese herbal formula, ameliorates diet-induced obesity and hepatic steatosis by activating the AMPK/SREBP-1 and the AMPK/ACC/CPT1A pathways

Variations in morphology, physiology, and multiple bioactive constituents of Lonicerae Japonicae Flos under salt stress

A Review: The Triterpenoid Saponins and Biological Activities of Lonicera Linn.

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