Separation of furosemide, phenylbutazone and oxyphenbutazone in plasma by direct injection onto internal surface reversed-phase columns with systematic optimization of selectivity

Pinkerton, Thomas C.; Perry, John; Rateike, John D.

doi:10.1016/s0021-9673(00)94862-3

Cited by 41 publications

(8 citation statements)

References 9 publications

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“…ISRP supports allowed to withstand several hundred plasma or serum injections (total volume of 6-7 ml) without losing performance [26,27]. GFF material has been recognized as a suitable approach for the direct injection of drugs and metabolites in biological matrices [26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43]. This support also shows a real potential for the direct analysis of endogenous substances in serum [44,45] and peptides from complex extracts [46,47].…”

Section: Restricted Access Mediamentioning

confidence: 99%

Restricted access materials and large particle supports for on-line sample preparation: an attractive approach for biological fluids analysis

Souverain

Rudaz

Veuthey

2004

Journal of Chromatography B

250

124

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Section: Restricted Access Mediamentioning

confidence: 99%

Restricted access materials and large particle supports for on-line sample preparation: an attractive approach for biological fluids analysis

Souverain

Rudaz

Veuthey

2004

Journal of Chromatography B

250

124

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“…Scott reports that the retention is exclusively controlled by dispersive interactions [23]. Other types of grafts leading to reversed-phase silicas such as horizontal polymeric bonding ( Figure 8) (selfassembled monolayer), coated silicas ( Figure 9) or internal surface reversed phase ( Figure 10) are also manufactured [81]. However, these oligomeric phases are the most difficult to synthetise.…”

Section: S-116mentioning

confidence: 99%

Silica and other materials as supports in liquid chromatography. Chromatographic tests and their importance for evaluating these supports. Part I

et al. 2001

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Reversed-phase liquid chromatography (RP-HPLC) has become a powerful and widely employed technique in the separation and analysis of a great variety of compounds with different functionalities. The most common type of stationary phase for RP-HPLC consists of nonpolar, hydrophobic organic species (e.g., octyl, octadecyl) attached by siloxane bonds to the surface of a silica support. In the first part of this article, a description of the many beneficial properties that make porous silica the most employed support in RP-HPLC will be presented, starting from the synthesis of silica. It is noteworthy that the chromatographic properties of the final column are strictly correlated to the preparation type. A silica surface possesses a number of attractive properties, but also some drawbacks. Unreacted or residual silanols interact with basic compounds and can induced peak tailing, which means a loss in chromatographic performance. This problem has lead many manufactures to produce stationary phases with reduced silanol activity which improve dramatically the peak shape of basic compounds. In the second part of this review, different approaches are proposed to obtain less reactive stationary phases

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“…The most common commercial column is the ISRP GFFII column from Regis Technologies, where a monofunctional glycidoxypropyl linkage is used to attach the tripeptide to the inner surface . Applications of this unique functional group in a RAM support have been demonstrated for the analysis of drug compounds and their metabolites, primarily from plasma and serum . The GFF media were the first type of RAM to be developed and they have been demonstrated to be a viable option for rapid sample cleanup and effective sample preparation.…”

Section: Isp Trap Columnsmentioning

confidence: 99%

Restricted access media as a streamlined approach toward on‐line sample preparation: Recent advancements and applications

Yang

Fan

Classon³

et al. 2013

J of Separation Science

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Restricted access media (RAM) as an alternative to traditional sample preparation strategies are reviewed. RAM comprise chromatographic packing materials that combine, typically, a restrictive outer surface to exclude the retention of large biomolecules, which are common interferences in biological fluids, with retentive inner pores or phases to capture analytes of interest. Through the years, a variety of RAM formats have been created, including internal surface phases, semipermeable phases, and molecularly imprinted polymer phases. Many phases are commercially available through a variety of manufacturers. The use of on-line sample preparation using RAM can increase throughput, recovery, and ease of use for sample preparation of complex biological matrices. The state-of-the-art with respect to production and use of these media for a variety of applications is covered.

show abstract

Separation of furosemide, phenylbutazone and oxyphenbutazone in plasma by direct injection onto internal surface reversed-phase columns with systematic optimization of selectivity

Cited by 41 publications

References 9 publications

Restricted access materials and large particle supports for on-line sample preparation: an attractive approach for biological fluids analysis

Restricted access materials and large particle supports for on-line sample preparation: an attractive approach for biological fluids analysis

Silica and other materials as supports in liquid chromatography. Chromatographic tests and their importance for evaluating these supports. Part I

Restricted access media as a streamlined approach toward on‐line sample preparation: Recent advancements and applications

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