Separation of Long-Lived Radionuclides on QMA Light Anion-Exchange Cartridge in Manufacture of Radiopharmaceutical Preparations Based on 18F

The accumulation of unwanted long-lived radionuclides during the production of 18F-based radiopharmaceuticals using the IBA Cyclone 18/9 HC cyclotron is considered. Using high-resolution gamma-ray spectrometry with HPGe detectors, the identification of radionuclides and the assessment of activity in activated components (stripper, target entrance window) of the "medical" 18-MeV cyclotron IBA Cyclone 18/9 were carried out. More than 20 unwanted radionuclides have been identified in irradiated water. Various mechanisms for the entry of longlived radionuclides into irradiated water are described. The results obtained are of great importance for optimizing the methods of radioactive waste management in the production of radiopharmaceuticals and, as a result, minimizing the radiation exposure of personnel.

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Accumulation of Radionuclides in Replaceable Parts and Water Target Cyclotron

KIYKO

Вабищевич

et al. 2022

HERALD OF POLOTSK STATE UNIVERSITY. Series С FUNDAMENTAL SCIENC

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APPLICATION ANALYSIS OF THE GAMMA-BETA SPECTROMETER MKS-AT1315 TO CONTROL UNWANTED RADIONUCLIDES, FORMED DURING THE PRODUCTION OF RADIOPHARMACEUTICALS

KIYKO

Вабищевич

et al. 2023

HERALD OF POLOTSK STATE UNIVERSITY. Series С FUNDAMENTAL SCIENC

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Simultaneous measurements of γ- and β-emitting radionuclides in regenerated water and sorption purification cartridges used in the production of radiopharmaceuticals based on 18F were carried out with the MKSAT1315 spectrometer. It was found that the bands observed in the gamma-spectra are due to isotopes of cobalt 55Co, 56Co, 58Co, 57Co, nickel 57Ni, manganese 54Mn and zinc 65Zn, the prospects of using the gamma-beta spectrometer MKS-AT1315 for operational control of the content of undesirable technological radionuclides in the production of radiopharmaceuticals based on 18F are shown.

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Separation of Long-Lived Radionuclides on QMA Light Anion-Exchange Cartridge in Manufacture of Radiopharmaceutical Preparations Based on 18F

Cited by 2 publications

References 11 publications

Accumulation of Radionuclides in Replaceable Parts and Water Target Cyclotron

Accumulation of Radionuclides in Replaceable Parts and Water Target Cyclotron

APPLICATION ANALYSIS OF THE GAMMA-BETA SPECTROMETER MKS-AT1315 TO CONTROL UNWANTED RADIONUCLIDES, FORMED DURING THE PRODUCTION OF RADIOPHARMACEUTICALS

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