Separation of Low-Molecular Organic Compounds from Complex Aqueous Mixtures by Extraction

Schügerl, K.; Degener, W.; Frieling, Petra von; Handojo, Lienda; Kirgios, Ioannis

doi:10.1007/978-94-009-0783-6_26

Cited by 11 publications

(19 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A strong interaction between the polar organic solvent and the complex gives only the (1,1) complex. On the other hand, a few researchers (2, 13, 14) have shown that the reaction equilibrium in the liquid−liquid system with a nonpolar organic solvent could be described by the same equilibrium expression as that in the system with the polar organic solvent. Therefore, we first selected the following reaction equilibrium as one of the equilibrium models: The mass balance equations are represented by: where only penicillin acid anion (P − ) and undissociated penicillin acid (HP) exist in the aqueous phase, and C P and C HP are their concentrations, respectively.…”

Section: Extraction Equilibrim Modelsmentioning

confidence: 99%

Reaction Equilibrium of Penicillin G with Amberlite LA‐2 in a Nonpolar Organic Solvent

Lee

Ahn

Kim³

2002

Biotechnology Progress

View full text Add to dashboard Cite

Studies have been made of the reactive extraction of penicillin G by Amberlite LA-2, a secondary amine, dissolved in kerosene. On the basis of the previous works about extraction equilibria of monocarboxylic acids by some secondary amines in low polar organic solvents, four equilibrium models were suggested to describe the reaction equilibrium of penicillin G in the liquid-liquid extraction system. The calculated results from the models were compared with the experimental data of 96 runs, and only two equilibrium models seemed to be probable. Ultimately, the most reasonable extraction equilibrium model was chosen through spectroscopic studies on organic solutions obtained by five specific extraction equilibrium experiments.

show abstract

Section: Extraction Equilibrim Modelsmentioning

confidence: 99%

Reaction Equilibrium of Penicillin G with Amberlite LA‐2 in a Nonpolar Organic Solvent

Lee

Ahn

Kim³

2002

Biotechnology Progress

View full text Add to dashboard Cite

show abstract

“…Extraction with conventional solvents, such as ketones and alcohols, is not an efficient method for the recovery of most carboxylic acids due to rather low distribution ratios. Therefore, reactive extraction, which has greater distribution of acid into the solvent phase than conventional solvent extraction due to the formation of complex with the functional group of a solute, has been shown to be a promising technique for the recovery of hydroxycarboxylic acids (3–10).…”

Section: Introductionmentioning

confidence: 99%

Kinetics of the Extraction of Succinic Acid with Tri‐n‐octylamine in 1‐Octanol Solution

Jun

Huh

Hong

et al. 2005

Biotechnology Progress

View full text Add to dashboard Cite

Kinetic studies for the extraction of succinic acid from aqueous solution with 1-octanol solutions of tri-n-octylamine (TOA) were carried out using a stirred cell with a microporous hydrophobic membrane. The interfacial concentrations of species were correlated and thus the intrinsic kinetics was obtained. The overall extraction process was controlled by the chemical reaction at or near the interface between the aqueous and organic phases. The formation reaction of succinic acid-TOA complex was found to be first order with respect to the concentration of succinic acid in the aqueous phase and the order of 0.5 with respect to that of TOA in the organic phase with a rate constant of (3.14 +/- 0.6) x 10(-8) m(2.5) x mol(-0.5) x s(-1). The dissociation reaction of succinic acid-TOA complex was found to be the second-order with respect to that of succinic acid-TOA complex in the organic phase and the order of -2 with respect to that of TOA in the organic phase with a rate constant of (1.44 +/- 1.4) x 10(-4) mol x m(-2) x s(-1).

show abstract

“…Algunos estudios publicados indican que los sistemas convencionales de extracción que utilizan agentes hidrocarbonados como alcoholes, cetonas o ésteres inmiscibles en agua, son relativamente ineficaces para la recuperación de aminoácidos de disoluciones acuosas diluidas. Esto se debe a que los aminoácidos no pueden extraerse eficazmente con disolventes no polares o de baja polaridad, ya que en fase acuosa las especies de los aminoácidos presentan carga, positiva la especie catiónica, negativa la especie aniónica o ambas la especie anfótera, reduciéndose considerablemente la solubilización del aminoácido en el disolvente no polar (Kertes A.S. et al, 1986;Schügerl K. et al, 1992). Nuevos extractantes consistentes en macrociclos hidrocarbonados se están estudiando para la recuperación de aminoácidos, a estos extractantes se les introduce grupos funcionales para crear interacciones específicas con las moléculas que se van a extraer.…”

Section: Equilibrios De Extracción De Aminoácidos Y Betaínaunclassified

“…Además, los aminoácidos prácticamente no se extraen con aminas alifáticas primarias, secundarias o terciarias, ya que el mecanismo de extracción implica la transferencia previa del protón y posteriormente la extracción del anión del aminoácido, proceso imposibilitado por el carácter anfotérico de los aminoácidos en disolución acuosa. Así, el único enlace de hidrógeno que puede formar el átomo de nitrógeno de la amina y el grupo ácido del aminoácido, sin previa transferencia del protón, es demasiado débil para producir la transferencia del aminoácido de la fase acuosa a la orgánica (Schügerl K. et al, 1992).…”

Section: Equilibrios De Extracción De Aminoácidos Y Betaínaunclassified

“…et al, 1974) y de uso reciente en la recuperación de ácidos carboxílicos (Clark G.A. et al, 1987;Ruiz M.O., 2000;Qin W. et al, 2003), en la eliminación de contaminantes de efluentes industriales y de alcantarillado (Salazar E. et al, 1992) y en la extracción de aminoácidos (Schügerl K. et al, 1992;Escalante H. et al, 2000;Ruiz M.O., 2002;. Las principales ventajas de utilizar estos extractantes (Schügerl K., 1987) son:…”

Section: Equilibrios De Extracción De Aminoácidos Y Betaínaunclassified

See 1 more Smart Citation

Separación de aminoácidos y derivados utilizando resinas impregnadas de extractante

Ronda¹,

Isabel²

View full text Add to dashboard Cite

The separation of amino acids (α-phenylglycine and aspartic acid) and by-products (betaine), as they are biocompounds of food and pharmaceutical interest, was carried out with a new extraction technology using extractant-impregnated resins. This study demonstrates that this new technology is an alternative to the conventional separation processes.Biocompounds are extensively used as raw materials in the chemical, pharmaceutical, food and health industries. It is important to recover them from fermentation broths or process effluents for economic and environment reasons in order to minimize water pollution. α-Phenylglycine is an important precursor in pharmaceutical industry in the production of β-lactam antibiotics, such as cephalosporines. Aspartic acid and phenylalanine are mainly used in the synthesis of the low-calorie sweetener, aspartame. Betaine is used as a digestive aid being particularly helpful for persons with insufficient acid production in the stomach, it is also used to reduce homocysteine levels, as an ingredient in toothpaste, in cosmetic products and in feeds.Extraction with impregnated resins (EIR) is a novel hybrid technology which combines the high capacity and selectivity of liquid-liquid extraction technique, with the advantages of separation processes with ion exchange resins, which allow to process high quantities of diluted solutions, using simple and low cost equipments, such as fixed or fluidized beds. In this work separation of amino acids was investigated by impregnation of Amberlite XAD-4 resin with tri-alkylmethylammonium chloride (TOMAC) and for betaine separation the same resin was impregnated with dinonilnaftalensulfonic acid (DNNSA). Research was carried out by the following steps:-Impregnation study of the polymeric support with the extractant.-Experimental determination of α-phenylglycine and aspartic acid extraction equilibria, isolated or in binary mixtures with EIR, under different initial amino acid concentrations and pH. Equilibrium models which take account of the simultaneous reactive extraction of the amino acids or hydroxyl ions with the extractant are performed in order to design separation dynamic process with EIR fixed beds.-Kinetics studies in a batch stirred tank. The sorption rates of α-phenylglycine and aspartic acid isolated and in binary mixtures with EIR have been investigated. Kinetic models were used for the determination of the rate-controlling steps and diffusion coefficients values.-Extraction and back-extraction of α-phenylglycine and aspartic acid in fixed bed packed with EIR were studied. The effects of the feed flow rate, amino acid concentration in the feed solution, pH and extractant concentration in the impregnated resin on the breakthrough curves, were investigated. A dynamic model that considers intraparticle diffusion and external liquid film diffusion as limiting steps in mass transfer rates is applied. It was also designed an extraction and back-extraction process with two fixed beds packed with EIR for fractionation of amino acids in mixtu...

show abstract

Separation of Low-Molecular Organic Compounds from Complex Aqueous Mixtures by Extraction

Cited by 11 publications

References 3 publications

Reaction Equilibrium of Penicillin G with Amberlite LA‐2 in a Nonpolar Organic Solvent

Reaction Equilibrium of Penicillin G with Amberlite LA‐2 in a Nonpolar Organic Solvent

Kinetics of the Extraction of Succinic Acid with Tri‐n‐octylamine in 1‐Octanol Solution

Separación de aminoácidos y derivados utilizando resinas impregnadas de extractante

Contact Info

Product

Resources

About