Separation of Quingestanol Acetate from Sesame Oil Solution and Its Determination in Combinations withEthinyl Estradiol or Quinestrol

Penner, Melvin H.; Tsilifonis, Dimitri C.; Chafetz, Lester

doi:10.1002/jps.2600600923

Cited by 6 publications

(2 citation statements)

References 7 publications

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“…Procedures using partition chromatographic methods of separation include: a method for trisulfapyrimidines (286), a method for the determination of benzthiazide, hydrochlorothiazide, and hydroflumethiazide (114), a procedure for the determination of acetaminophen and salicylamide in tablets and capsules (151), the assay of ipecac alkaloids (830), a specific assay for the drug levamisole (95), a method for methylene blue, methenamine, phenylsalicylate, benzoic acid, atropine sulfate, and hyoscyamine (881), the determination of quingestanol acetate in dosage form (265), the determination of furazolidone and nifuroxime in suppositories (376), a method for sulfanilamide in preparations (875), the determination of noscopine in cough preparations (110), the determination of amyl-p-dimethylaminobenzoate in suntan preparations (89), and a method for the determination of mestranol in tablets (51).…”

Section: Biological Analysismentioning

confidence: 99%

Ultraviolet spectrometry

Hummel¹,

Kaufman²

1972

Anal. Chem.

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Section: Biological Analysismentioning

confidence: 99%

Ultraviolet spectrometry

Hummel¹,

Kaufman²

1972

Anal. Chem.

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“…Penner et al (36) recently reported a procedure which provides selective adsorption of 17e~-ethynyl steroids on silver nitrate-impregnated Florisil to separate it from its oil vehicle. After displacement with ethanolic ammonium chloride the 17a-ethynyl steroid, quingestanol acetate, was determined spectrophotometrically.…”

mentioning

confidence: 99%

Analysis of oil‐based pharmaceuticals

Smith

1972

J Americ Oil Chem Soc

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Oils of animal, mineral and vegetable origin are used in the formulation of pharmaceuticals. In most cases the analysis of these pharmaceuticals requires the separation of the drug substance from the oil components prior to its quantitation, the required degree of separation depending on the specificity of the quantitation method. When the physical properties of the drug substance are quite similar to those of components of the oil, the separation of the drug becomes complex. Column partition chromatography provides an excellent means of separating steroids from the vegetable oil vehicles used in injectables. Both reverse phase and direct phase techniques are applied to the separation of the steroids from the glyceride, stern and triterpenoid fractions of the oil. Illustrations are provided to demonstrate the application of thin layer chromatography, paper chromatography, gas chromatography, gel permeation chromatography and adsorption chromatography in the analysis of oil solutions, oil-based dermatological preparations and suppositories.

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