Separation of [¹⁸F]fluoride ion from proton‐irradiated [¹⁸O]water within an EOF‐driven micro‐reactor powered by the Capilix Capella™ platform

Batch-reactor microfluidic device: first human use of a microfluidically produced PET radiotracer

“…Specifically, a microfluidic device receives milliliter-scale volumes of irradiated water from a cyclotron and then has to produce milliliter-scale volumes of the final product. Efficient conversion from the macro-scale to micro-scale is in development stage so far, although interesting reports of fluoride concentration with absorbents 12,13 and electrochemical devices 14,15 have appeared recently.…”

Microfluidic devices for radio chemical synthesis

“…First attempts to perform this procedure were made right at the onset of microfl uidic radiochemistry. 80 Glossy carbon electrodes were utilized for this application with ~80% effi ciency. 81 Platinum electrodes allowed for some improvements over glossy carbon, but the overall effi ciency of the process was still far from production standards.…”

Implementation of iMiDEV™, a new fully automated microfluidic platform for radiopharmaceutical production

“…23 However, some progress has been achieved in the development of the fluoride-18 and gallium-68 concentration systems adapted or integrated into microfluidic cassettes. [24][25][26][27][28][29] Recently, a new custom platform that can perform steps starting from radionuclide concentration and finishing with purification of the final product has been shown to successfully produce a [ 18 F] fallypride dose. 19 Nevertheless, fabrication and industrialisation of a fully integrated on-chip platform remains an engineering challenge of great interest.…”