Separation of the low-molecular-weight components of aqueous humor, vitreous and subretinal fluid by gel filtration

Falbe-Hansen, I.

doi:10.1016/s0014-4835(66)80008-8

Cited by 4 publications

(1 citation statement)

References 7 publications

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“…concerning the SRF but also of the vitreous fluid as well under normal conditions as when the retina is detached (8,17).…”

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Analysis of the Subretinal Fluid

Edmund

1968

Acta Ophthalmologica

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The basis of a retinal detachment is a coincidence of pathological conditions in the choroid, the retina and the vitreous body (1). Amazingly often, however, the pathology of the choroid is not recognized at least clinically and as well known a detached retina might be observed without the presence of a contemporary retinal defect or any other pathological or degenerative sign in the detached retina. On the other hand wide-spread retinal degenerations and in some cases single or even multiple holes or tears have been observed without a simultaneous present or future occurring detachment (2 1). From the very moment a retinal detachment is clinically recognizable, however, subretinal fluid will always be present. Further, once present this subretinal fluid only in extremely rare cases disappears sponteaneously, but on the contrary reveals a tendency to increase resulting in a total retinal detachment.It seems obvious therefore to look for the explanation of the genesis of the idiopathic retinal detachment in the subretinal fluid (SRF). On the basis of an estimation of the viscosity of the SRF and the vitreous fluid Leber suggested that these two fluids had the same protein content, an assumption that plays an important part in the so-called retention theory for the formation of the SRF and in which Gonin and his scool emphazises the importance of the retinal tear in the occurrence and treatment of the detachment.This theory as many others of the widely accepted theories explaining the etiology of retinal detachment are based on the idea that the SRF and the vitreous are of almost similar physico-chemical composition. If one wishes to solve the question of the genesis of the idiopatic retinal detachment based on a physico-chemical analysis it is nessesary, however, to have some exact information of the physical properties and the chemical composition not only

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“…concerning the SRF but also of the vitreous fluid as well under normal conditions as when the retina is detached (8,17).…”

mentioning

confidence: 99%