Separation of vitamin A from carotenoids in micro samples of serum

Awdeh, Z. L.

doi:10.1016/0003-2697(65)90249-6

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1966

1973

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Cited by 14 publications

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Failure of Enzymic Cleavage of β-Carotene

McLaren¹,

Zekian²

1971

Am J Dis Child

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A 10-year-old Lebanese Arab girl had vitamin A deficiency as evidenced by night blindness, bilateral Bitot's spots, and very low plasma vitamin A concentration (7\g=m\g/ 100 ml). Total plasma carotenoid values were high with about 50% as \g=b\-carotene. Repeated blood sampling after large doses of \g=b\-carotene failed to produce any retinyl ester in the plasma whereas there was significant rise of ester levels in three control subjects. Preformed vitamin A cured the clinical condition and caused retinyl ester to appear in the plasma. There was no malabsorption, hypothyroidism, or liver dysfunction. The evidence suggests failure of enzymic conversion of \g=b\-carotene to retinal in the intestine as the cause of vitamin A deficiency.

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