Abstract. We prove that a Siegel cusp form of degree 2 for the full modular group is determined by its set of Fourier coefficients a(S) with 4 det(S) ranging over odd squarefree integers. As a key step to our result, we also prove that a classical cusp form of half-integral weight and level 4N , with N odd and squarefree, is determined by its set of Fourier coefficients a(d) with d ranging over odd squarefree integers, a result that was previously known only for Hecke eigenforms.