Sepse Neonatal: Mortalidade Em Município Do Sul Do Brasil, 2000 a 2013

Alves, Jakeline Barbara; Gabani, Flávia Lopes; Ferrari, Rosângela Aparecida Pimenta; Tacla, Mauren Teresa Grubisich Mendes; Júnior, Arnildo Linck

doi:10.1590/1984-0462/;2018;36;2;00001

Cited by 27 publications

(36 citation statements)

References 17 publications

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“…Nevertheless, it is recognized that neonatal sepsis is underreported owing to the discrepancies in its definition and surveillance worldwide (12,13). Additionally, in a recent study performed in the south of Brazil, a neonatal sepsis rate of 30.7% was responsible for neonatal mortality, which is also a high rate (14). Furthermore, the diagnosis of maternal infection in a woman with preterm labor does not necessarily imply that it is the only cause of prematurity.…”

Section: ' Discussionmentioning

confidence: 99%

The role of maternal infection in preterm birth: evidence from the Brazilian Multicentre Study on Preterm Birth (EMIP)

Tedesco¹,

Galvão²,

Guida³

et al. 2020

Clinics

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OBJECTIVES: Evidence suggests that infection or inflammation is a major contributor to early spontaneous preterm birth (sPTB). Therefore, this study aimed to investigate the development and causes of maternal infection associated with maternal and neonatal outcomes in women with sPTB. METHODS: This was a secondary analysis of a multicenter cross-sectional study with a nested case-control component, the Brazilian Multicentre Study on Preterm Birth (EMIP), conducted from April 2011 to July 2012 in 20 Brazilian referral obstetric hospitals. Women with preterm birth (PTB) and their neonates were enrolled. In this analysis, 2,682 women undergoing spontaneous preterm labor and premature pre-labor rupture of membranes were included. Two groups were identified based on self-reports or prenatal or hospital records: women with at least one infection factor and women without any maternal infection (vulvovaginitis, urinary tract infection, or dental infection). A bivariate analysis was performed to identify potential individual risk factors for PTB. The odds ratios (ORs) with their respective 95% confidence intervals were calculated. RESULTS: The majority of women with sPTB fulfilled at least one criterion for the identification of maternal infection (65.9%), and more than half reported having urinary tract infection during pregnancy. Approximately 9.6% of women with PTB and maternal infection were classified as having periodontal infection only. Apart from the presence of a partner, which was more common among women with infectious diseases (p=0.026; OR, 1.28 [1.03-1.59]), other variables did not show any significant difference between groups. CONCLUSION: Maternal infection was highly prevalent in all cases of sPTBs, although it was not clearly associated with the type of PTB, gestational age, or any adverse neonatal outcomes. CLINICS 2020;75:e1508 Maternal infection in preterm birth Tedesco RP et al.

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Section: ' Discussionmentioning

confidence: 99%

The role of maternal infection in preterm birth: evidence from the Brazilian Multicentre Study on Preterm Birth (EMIP)

Tedesco¹,

Galvão²,

Guida³

et al. 2020

Clinics

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“…Additionally, reference numbers are di cult to draw in, as many details and the place of study are not clear or not provided. In a study from 2018 carried out in Brazil, a neonatal mortality rate with sepsis involvement reported 2.3 deaths per one thousand live births [194]. Given this context, the mortality in the cited study [48] appears high and further explanation would have been highly desired.…”

Section: Evaluation Of Side Effects and Contraindicationsmentioning

confidence: 99%

Recommendation of Neurorehabilitation according to the Padovan-Method Neurofunctional Reorganisation® for treating neurodevelopmental disorders: a systematic review

Vogel

Ostermann

Vogel

et al. 2021

Preprint

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Background: The PADOVAN-METHOD NEUROFUNCTIONAL REORGANISATION® is a promising approach in speech therapy for treating neurodevelopmental disorders of traumatic or congenital origin. Its use is based on a long-time experience of certified therapists; however, its efficacy and safety has not yet been assessed in a systematic review. This report aims to gain evidence for the use of the therapy method. Methods: Guidelines of PRISMA, the Cochrane Collaboration Handbook, MECIR and GRADE were followed. General databases (Cochrane Library, PubMed, AWMF, Anthromedics) and additional 38 databases including grey literature were searched. Hand search was also done and experts were contacted to retrieve unpublished manuscripts. All trials investigating the effect of the method in comparison to either no intervention, alternative as state of the art or placebo intervention in English, Portuguese and German language were included. No restriction regarding study design was applied. Data related to the intervention outcome and the study method was extracted and analysed idependently. Risk of Bias was assessed using ROBINS-I for non-RCTs, adherence to CARE-Guidelines was analysed for case series or reports and keeping the Declaration of Helsinki was checked for all items. Results are presented both in evidence profiles and summary of findings tables according to GRADE. Results: Amongst 98 records assessed for eligibility, and four studies and 14 case reports were identified as appropriate for analysis with a total of n = 196 participants. Duration of reported interventions was between two days and two years. Microcephalia, down-syndrome, unspecified neurological disorders and myo-functional disorders were the main conditions of the patients with neurodevelopmental disorders. Only indirect overlapping of operationalised criteria was found; therefore conclusions are limited. Conclusion: The Padovan-Method® is a holistic therapy approach claiming feasibility to a large group of disorders making proof of efficacy difficult. An application of therapy according to the Padovan-Method® by trained therapists might be considered by clinicians (weak recommendation), and a contribution to the relief of symptoms or improvements of the conditions might be gained. Therefore, development and validation of therapy protocols and further investigation are required. PROSPERO Registration: CRD42020156124.

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“…Several authors [22][23][24] state that the death rate due to sepsis is high and the risk of sepsis increases in prematurity in proportion to the decrease in birth weight; evaluation of levels of IL-6 and CPR for the diagnosis of early sepsis may explain the difference between septic and non-septic patients. Neonatal sepsis, characterized by systemic signs of infection in the first month of life, remains an important clinical syndrome, with high mortality and morbidity rates; the use of IL-6 and CRP in combination have been shown to be useful in the early diagnosis of sepsis in newborns.…”

Section: Distribution Of the Findings Related To Weight Gestational mentioning

confidence: 99%

Maternal risk factors in full-term newborns with early onset sepsis related with Interleukin-6 in umbilical blood

González-Andrade¹

2019

archmed

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Background: to determine the relationship and association of early sepsis with interleukin-6 measured in umbilical blood, as well as gestational age and birth weight, prenatal history of the mother pathologies during pregnancy, in full-term newborns at the Neonatology Service of Carlos Andrade Marín Hospital (Quito). Subjects and methods: epidemiological, observational, analytical, cross-sectional. 200 newborns were analyzed. IL-6 was determined by Elisa. Results: newborn mean gestational age 38.4±2 weeks, mean weight 2871±532.4 grams, cutoff point interleukin 6 ≤14pg/uL; mean of IL6. 58±99,1 pg/uL; male sex was 43.9%, female sex 56.1%; preeclampsia of the mother 22.4%, prenatal infection of the urinary tract 20.4%; vaginitis/vaginosis 19.4%; IL6 values ≤ 14 pg/uL in 63.3% of patients; IL6 values of >14 pg/uL 36.7%; relationship with sepsis in all, p<0.05; relationship of prenatal pre-maternity of the mother and neonatal sepsis. p<0.05; relationship between vaginitis/vaginosis of the mother with neonatal sepsis; p<0.05; OR: 38.88 IC95% (4.912-307.728); association between sepsis and risk factors, IL6, gestational age in weeks, weight, prenatal preeclampsia, prenatal urinary tract infection, vaginitis/vaginosis, p<0.05. Conclusion: It is concluded that there is a relationship of risk factors, such as, gestational age in weeks, weight, prenatal preeclampsia, prenatal UTI, vaginitis/vaginosis and values of interleukin 6 ≤ 14 pg/uL. The mean gestational age was 38.4 weeks, and average weight 2871 grams in the newborns analyzed.

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Sepse Neonatal: Mortalidade Em Município Do Sul Do Brasil, 2000 a 2013

Cited by 27 publications

References 17 publications

The role of maternal infection in preterm birth: evidence from the Brazilian Multicentre Study on Preterm Birth (EMIP)

The role of maternal infection in preterm birth: evidence from the Brazilian Multicentre Study on Preterm Birth (EMIP)

Recommendation of Neurorehabilitation according to the Padovan-Method Neurofunctional Reorganisation® for treating neurodevelopmental disorders: a systematic review

Maternal risk factors in full-term newborns with early onset sepsis related with Interleukin-6 in umbilical blood

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