Sepsis-induced cholestasis

Chand, Nisha; Sanyal, Arun J.

doi:10.1002/hep.21480

Cited by 292 publications

(246 citation statements)

References 61 publications

Supporting

Mentioning

225

Contrasting

Unclassified

Order By: Relevance

“…They highlight a study on the potential utility of aggressive maintenance of normoglycemia in improving outcomes in subjects admitted to a surgical intensive care unit who were being ventilated. 1 In this study, the greatest benefits were seen in those who had a septic focus. We had not discussed this because the focus of our paper was sepsis-induced cholestasis rather than sepsis itself.…”

Section: Replymentioning

confidence: 61%

“…We read with interest the report by Higashiyama et al, 1 who found that bone marrow (BM)-derived cells contributed to the regression of liver fibrosis in a murine model and that these cells were likely to be macrophages secreting matrix metalloproteinase (MMP)-9 and MMP-13. This agrees with previous work demonstrating a role for BM-derived macrophages in liver fibrosis resolution.…”

Section: To the Editormentioning

confidence: 99%

See 1 more Smart Citation

Sepsis‐induced cholestasis†

et al. 2007

View full text Add to dashboard Cite

Section: Replymentioning

confidence: 61%

Section: To the Editormentioning

confidence: 99%

Sepsis‐induced cholestasis†

et al. 2007

View full text Add to dashboard Cite

“…[7][8][9][10][11][12][13][14][15] Some bacteria including E. Coli have been associated with increased levels of total serum bilirubin levels. 16 Amongst the patients diagnosed with Acute appendicitis pre-operatively (n=70), 47 patients (47%) were found to have increased bilirubin (>1.2 mg/dL) while 53 patients (53%) has normal bilirubin levels (≤1.2 mg/dL).…”

Section: Discussionmentioning

confidence: 99%

Hyperbilirubinemia: a new diagnostic marker for perpendicular perforation

et al. 2017

View full text Add to dashboard Cite

Background: Appendicitis is one of the commonest causes of abdominal pain requiring emergency surgery. Diagnosing acute appendicitis clinically still remains a common surgical problem as the clinical signs and symptoms of other abdominal pathologic conditions mimic the diagnosis of acute appendicitis. Delay in diagnosis and surgery for this condition may lead to various complications like perforation, abdominal abscess etc. By knowing perforation prior to the exploration, we can manage the condition very effectively in terms explaining the prognosis of disease, morbidity of surgery, wound infection, and requirement of emergent nature of surgery. Aim of the study is to determine of role of hyperbilirubinemia as a new diagnostic marker to predict gangrenous/perforated appendicitis.Methods: It’s a retrospective study was conducted in the department of surgery, MMCRI, Mysore during the period of January 2015 to December 2015 total of 100 patients with clinical as well as ultrasonographic diagnosis of acute appendicitis or appendiceal perforation were made. The serum bilirubin test was carried out in all the patients pre-operatively.Results: In the study, the total 100 patients enrolled for the study, hyperbilirubinemia (> 1.2 mg/dL) in present study was found in 47 patients with 19 acute and 28 patients perforated appendicitis of all the 100 patients while 53 patients had normal bilirubin levels (≤ 1.2 mg/dL) 51 patients acute and 2 patients perforated appendix.Conclusions: Total serum bilirubin appears to be a new promising laboratory marker for diagnosing appendicular perforation. The patients with clinical signs and symptoms of appendicitis and with hyperbilirubinemia without elevation of liver enzymes should be identified as having a higher probability of appendicular perforation, suggesting total serum bilirubin levels have a predictive potential for the diagnosis of appendicular perforation.

show abstract

“…Jaundice may result either directly from bacterial products causing liver injury or as a consequence of host's response to infection. Frequently both factors contribute to the development of jaundice [6].…”

Section: Discussionmentioning

confidence: 99%

“…The development of jaundice may occur from an aberration in the processing of bilirubin by hepatocytes or from other effects on the liver that lead to the accumulation of bilirubin in the body. Such processes include increased bilirubin load from hemolysis, hepatocellular injury and cholestasis from the septic state and from various drugs used for the treatment of sepsis [6].…”

Section: Introductionmentioning

confidence: 99%

Biochemical Evaluation of Serum Bilirubin Fractions and Liver Function Tests in Sepsis Neonates with Hyperbilirubinemia

Das¹,

Suma²,

Rasalkar³

et al. 2016

Int J of Biomed & Adv Res

View full text Add to dashboard Cite

Background: Neonatal sepsis remains one of the leading causes of morbidity and mortality both among term and preterm infants. Sepsis and meningitis are responsible for most of these deaths. According to WHO estimates, there are about 5 million neonatal deaths a year. Jaundice and hepatic dysfunction frequently accompany a variety of bacterial infections. This study was aimed to evaluate bilirubin fractions and liver function tests in septic and non septic neonates with hyperbilirubinemia. Materials & Methods:A total of 41 neonates, their age ranged from (1-28 days), mean age sepsis cases 4.29±5.34 and mean age in non sepsis 2.27±4.44. The patients admitted to neonatology unit for the management of hyperbilirubinemia were included in this study. Out of 41, 20 babies having sepsis (17 were males & 3 were females) and 21 (15 were males & 6 were females) were non sepsis. All study subjects were studied for the serum bilirubin fractions and other liver function tests by using vitros dry chemistry analyzer. Results: In the present study, delta bilirubin (0.955 ±0.546) and conjugated bilirubin (1.17±2.10) levels are significantly increased in sepsis cases when compared to non sepsis controls. Conclusion: In conclusion, conjugated bilirubin and delta bilirubin were significantly increased in neonates suffering from sepsis with hyperbilirubinemia. By studying individual fractions of bilirubin, especially unconjugated bilirubin, conjugated bilirubin and delta bilirubin (not as direct and indirect bilirubin) will help in early diagnosis of sepsis and thus may help in better management of the sepsis neonates.

show abstract

Sepsis-induced cholestasis

Cited by 292 publications

References 61 publications

Sepsis‐induced cholestasis†

Sepsis‐induced cholestasis†

Hyperbilirubinemia: a new diagnostic marker for perpendicular perforation

Biochemical Evaluation of Serum Bilirubin Fractions and Liver Function Tests in Sepsis Neonates with Hyperbilirubinemia

Contact Info

Product

Resources

About