Sequelae from bacterial meningitis and their relation to the clinical condition during acute illness, based on 667 questionnaire returns. Part II of a three part series

Bohr, Vilhelm A.; Hansen, Bo Moelholm; Kjersem, Helge; Rasmussen, Niels; Johnsen, N. J.; Kristensen, H. Sund; Jessen, O

doi:10.1016/s0163-4453(83)90443-7

Cited by 48 publications

(29 citation statements)

References 7 publications

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“…This contrasts sharply with the findings of Bohr et al (1983b), who found a total of 34-6 % of 308 cases of meningococcal meningitis to have sequelae. The assessment of disability in the Scottish cases was objective as opposed to the subjective assessment in the cases reviewed by Bohr and colleagues but it would be interesting to review the final outcome in cases more closely to see whether Bohr's findings can be confirmed.…”

Section: Outcome Of Diseasecontrasting

confidence: 89%

Meningococcal infections in Scotland 1972–82

Fallon

Brown

Lore

1984

J. Hyg.

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SUMMARYStrains of Neisseria meningitidis isolated from patients with meningitis or septicaemia without meningitis in Scotland during the years 1972-82 have been reviewed together with details of the age, sex, disease and outcome of the patients from whom they were isolated. A total of 1185 strains were isolated, of which 927 were examined at the Meningococcal Reference Laboratory (Scotland): 19-3 % were of serogroup A, 63 % of group B, 9-6 % of group C, 6 % of W135 and 1-6 % of other groups. Non-groupable strains were rare. Disease was most common in the first years of life but there was a difference in the age distribution of disease due to the different serogroups, the proportion of disease due to group B being smaller in adults than that due to other serogroups. The overall mortality in meningitis was 7-5 % and in septicaemia was 20-6 %, although there were differences between the rates for the various serogroups. The serogroup distribution differed in disease as opposed to meningococci isolated from carriers although group B strains were predominant in both series. Overall, approximately 15 % of strains were resistant to sulphadiazine, the proportion of resistant group A strains being higher than that of other serogroups.

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Section: Outcome Of Diseasecontrasting

confidence: 89%

Meningococcal infections in Scotland 1972–82

Fallon

Brown

Lore

1984

J. Hyg.

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“…Acute bacterial meningitis is still a life-threatening invasive infectious disease. Despite effective antibiotic treatment, mortality remains as high as 30%, and only half of the survivors return to work (18,19). Clinical complications, such as the formation of brain edema, increased intracranial pressure, and alterations of the cerebral blood flow, contribute to the unfavorable outcome.…”

Section: Introductionmentioning

confidence: 99%

TRAIL limits excessive host immune responses in bacterial meningitis

Hoffmann

Priller²,

Prozorovski³

et al. 2007

J. Clin. Invest.

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Apart from potential roles in anti-tumor surveillance, the TNF-related apoptosis-inducing ligand (TRAIL) has important regulatory functions in the host immune response. We studied antiinflammatory effects of endogenous and recombinant TRAIL (rTRAIL) in experimental meningitis. Following intrathecal application of pneumococcal cell wall, a TLR2 ligand, we found prolonged inflammation, augmented clinical impairment, and increased apoptosis in the hippocampus of TRAIL -/-mice. Administration of rTRAIL into the subarachnoid space of TRAIL -/-mice or reconstitution of hematopoiesis with wild-type bone marrow cells reversed these effects, suggesting an autoregulatory role of TRAIL within the infiltrating leukocyte population. Importantly, intrathecal application of rTRAIL in wild-type mice with meningitis also decreased inflammation and apoptosis. Moreover, patients suffering from bacterial meningitis showed increased intrathecal synthesis of TRAIL.Our findings provide what we believe is the first evidence that TRAIL may act as a negative regulator of acute CNS inflammation. The ability of TRAIL to modify inflammatory responses and to reduce neuronal cell death in meningitis suggests that it may be used as a novel antiinflammatory agent in invasive infections.

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“…A reported 32% of survivors of bacterial meningitis have persistent headache. 6 In addition, Neufeld et al 7 reported an association between aseptic meningitis and persistent headache.…”

Section: Discussionmentioning

confidence: 99%