Sequence Analysis of the Plasmid pGY1 Harbored in Salmonella enterica Serovar Paratyphi A

Huang, Hanyu; Li, J.; Yang, Xiaoxia; Wang, Y. G.; Wang, Y. P.; Jiang, Tao; Huang, Yun‐Tzu; Zhang, X. L.

doi:10.1007/s10528-008-9216-0

Cited by 2 publications

(1 citation statement)

References 11 publications

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“…This is probably due to transfer of plasmids between the two serovars 19. Besides that, isolation of cryptic plasmid in a clinical strain of S. Paratyphi A was also reported by Huang et al 22.…”

Section: The Genome Features Of S Paratyphi Amentioning

confidence: 51%

Paratyphoid Fever: Splicing the Global Analyses

2014

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The incidence of enteric fever caused by Salmonella enterica serovar Paratyphi A (S. Paratyphi A) is increasing in many parts of the world. Although there is no major outbreak of paratyphoid fever in recent years, S. Paratyphi A infection still remains a public health problem in many tropical countries. Therefore, surveillance studies play an important role in monitoring infections and the emergence of multidrug resistance, especially in endemic countries such as India, Nepal, Pakistan and China. In China, enteric fever was caused predominantly by S. Paratyphi A rather than by Salmonella enterica serovar Typhi (S. Typhi). Sometimes, S. Paratyphi A infection can evolve into a carrier state which increases the risk of transmission for travellers. Hence, paratyphoid fever is usually classified as a “travel-associated” disease. To date, diagnosis of paratyphoid fever based on the clinical presentation is not satisfactory as it resembles other febrile illnesses, and could not be distinguished from S. Typhi infection. With the availability of Whole Genome Sequencing technology, the genomes of S. Paratyphi A could be studied in-depth and more specific targets for detection will be revealed. Hence, detection of S. Paratyphi A with Polymerase Chain Reaction (PCR) method appears to be a more reliable approach compared to the Widal test. On the other hand, due to increasing incidence of S. Paratyphi A infections worldwide, the need to produce a paratyphoid vaccine is essential and urgent. Hence various vaccine projects that involve clinical trials have been carried out. Overall, this review provides the insights of S. Paratyphi A, including the bacteriology, epidemiology, management and antibiotic susceptibility, diagnoses and vaccine development.

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Section: The Genome Features Of S Paratyphi Amentioning

confidence: 51%

Paratyphoid Fever: Splicing the Global Analyses

2014

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fpr , a Deficient Xer Recombination Site from a Salmonella Plasmid, Fails To Confer Stability by Dimer Resolution: Comparative Studies with the pJHCMW1 mwr Site

2010

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Salmonella plasmid pFPTB1 includes a Tn3-like transposon and a Xer recombination site, fpr, which mediates site-specific recombination at efficiencies lower than those required for stabilizing a plasmid by dimer resolution. Mutagenesis and comparative studies with mwr, a site closely related to fpr, indicate that there is an interdependence of the sequences in the XerC binding region and the central region in Xer site-specific recombination sites.

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Sequence Analysis of the Plasmid pGY1 Harbored in Salmonella enterica Serovar Paratyphi A

Cited by 2 publications

References 11 publications

Paratyphoid Fever: Splicing the Global Analyses

Paratyphoid Fever: Splicing the Global Analyses

fpr , a Deficient Xer Recombination Site from a Salmonella Plasmid, Fails To Confer Stability by Dimer Resolution: Comparative Studies with the pJHCMW1 mwr Site

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