Sequence analysis of the putative structural genes of hepatitis C virus from Japanese and European origin

Delisse, Anne-Marie; Descurieux, M.; Rutgers, Tineke; D'Hondt, E.; Wilde, Michel De; Arima, Terukatsu; Barrera-Sala, J.M.; Ercilla, M. G.; Ruelle, Jean-Louis; Cabezón, Teresa

doi:10.1016/0168-8278(91)90017-6

Cited by 19 publications

(6 citation statements)

References 7 publications

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“…36 Substantial sequence heterogeneity among patients with chronic HCV infection has been reported and was classified into multiple genotypes and subtypes. [4][5][6][7][8][9][10][11][12] The distribution of HCV genotypes seems to vary from one geographic region to another around the world, 37 which may have important implications in the development of a universally effective vaccine. In this study, we found that the HCV genotypes in hemodialysis patients from Syria are equally distributed between HCV genotype 1 and HCV genotype 4.…”

Section: Discussionmentioning

confidence: 99%

“…2,3 The HCV genome exhibits significant genetic heterogeneity and has been classified into at least six major genotypes. [4][5][6][7][8][9] The identification of HCV genotypes and subtypes by various investigators initially resulted in distinct classification schemes, causing confusion among clinician and researchers. Recently, a consensus nomenclature for the classification of HCV variants was proposed, and a criteria for the reporting of new genotypes was established.…”

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confidence: 99%

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Hepatitis C virus genotypes and hepatitis G virus in hemodialysis patients from Syria: identification of two novel hepatitis C virus subtypes.

Abdul‐Karim

Zein²,

Germer³

et al. 1998

The American Journal of Tropical Medicine and Hygiene

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High prevalence of hepatitis C (HCV) and hepatitis G (HGV) viruses has been reported among hemodialysis patients with substantial heterogeneity of HCV genotypes throughout the world. We studied HCV prevalence, clinical significance, genotype distribution, and HGV coinfection in hemodialysis patients from Syria. Ninety (75%) of 120 screened patients were HCV antibody positive. Forty-nine (87.5%) of 56 HCV antibody-positive patients had HCV RNA detected by the polymerase chain reaction. The HCV genotyping was possible in 37 of 49 patients (76%). The HCV genotype distribution was genotype 1a, seven (19%); genotype 1b, 10 (27%); genotype 4a, 11 (30%); unmatched sequences, nine (24%). Phylogenetic analysis of unmatched sequences indicated that they represent two distinct and novel subtypes of HCV genotype 4. Hepatitis G virus RNA was detected in 29 (59%) of the HCV RNA-positive patients. No differences were identified between patients infected with HCV alone and those coinfected with HGV. These data demonstrate that HCV infection is common in this population with a genotype distribution predominantly made up of types 1 and 4. Coinfection with HGV had no effect on the outcome of HCV infection.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Hepatitis C virus genotypes and hepatitis G virus in hemodialysis patients from Syria: identification of two novel hepatitis C virus subtypes.

Abdul‐Karim

Zein²,

Germer³

et al. 1998

The American Journal of Tropical Medicine and Hygiene

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“…There is considerable nucleotide variation in the genome of HCV isolated from different areas of the world [Kremsdorf et al, 1991;Weiner et al, 1991;Delisse et al, 1991;Mori et al, 19921. A prominent difference has been found between isolates originally obtained in Japanese and American subjects. Japanese sequences have been subsequently observed, however, in several other areas of the world.…”

Section: Discussionmentioning

confidence: 99%

Different genotypes of hepatitis C virus are associated with different severity of chronic liver disease

Pozzato

Kaneko

Moretti

et al. 1994

Journal of Medical Virology

141

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The presence of the "Japanese type" NS4 region was investigated in two series of patients (53 from Italy and 58 from Japan) with hepatitis C virus (HCV)-related chronic liver disease. The two populations were homogeneous as regard to age, male/female ratio, histological diagnosis, and serum aminotransferase activities. Genomic amplification was carried out by "nested" polymerase chain reaction (PCR) with a pair of primers synthesized according to the sequence of JK-1 isolated in Japan. The presence of viral replication was confirmed further by PCR amplification of the 5'NC region. The NS4 region of the Japanese strain was detected in 24 sera (45%) from Italy and in 44 (71%) from Japan. NS4-positive patients were significantly older and showed an ALT serum level significantly lower (P < 0.01) than NS4 negative cases in each group. Cirrhosis was significantly (P < 0.0007) more common in NS4-positive than in NS4-negative patients. The HCV genotype was subsequently obtained according to Okamoto. All the NS4-positive patients were infected by Type II, whereas in NS4-negative patients all four genotypes were present though Type II still constituted the majority. Cirrhosis was associated exclusively with Type II both in NS4-positive and -negative subjects. These data indicate that, although the positivity for NS4 "Japanese" region seems to be associated with a more aggressive liver disease, the most prevalent Type II predicts more specifically those who are likely to develop cirrhosis.(ABSTRACT TRUNCATED AT 250 WORDS)

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“…HCV-1b and HCV-1a subtypes are mostly prevalent in Europe and America, respectively [14,[18][19][20]; in Japan, subtype 1b is responsible for about 73% cases of HCV [21], and 2b and 2a subtypes are frequently found in Europe, North America, and Japan [21]. Genotype 4 is most commonly prevalent in the Middle East and North Africa [22,23]. Very few studies have been carried out in all provinces of Pakistan on the epidemiology of HCV genotypes [24,25].…”

Section: Introductionmentioning

confidence: 99%

Determination of hepatitis C virus genotypes circulating in different districts of Punjab (Pakistan)

Waqar¹,

Khan²,

Rehman³

et al. 2014

European Journal of Gastroenterology & Hepatology

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The study found a significantly high prevalence of HCV among the patients of Punjab. In addition, genotype 1a was found to be a significantly and rapidly increasing genotype in the study area. It appears that HCV-3a (the most prevalent genotype) may be replaced by genotype 1a. If this occurs, it will make the present scenario more complex in terms of response to therapy and economic burden on the health sector of Pakistan. HCV infection is more common in the age group of 21-40 years. All the genotypes were distributed at the same frequency in men and women.

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Sequence analysis of the putative structural genes of hepatitis C virus from Japanese and European origin

Cited by 19 publications

References 7 publications

Hepatitis C virus genotypes and hepatitis G virus in hemodialysis patients from Syria: identification of two novel hepatitis C virus subtypes.

Hepatitis C virus genotypes and hepatitis G virus in hemodialysis patients from Syria: identification of two novel hepatitis C virus subtypes.

Different genotypes of hepatitis C virus are associated with different severity of chronic liver disease

Determination of hepatitis C virus genotypes circulating in different districts of Punjab (Pakistan)

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