Sequence and classification of FdPV2, a papillomavirus isolated from feline Bowenoid in situ carcinomas

Lange, Christian E.; Tobler, Kurt; Markau, T.; Alhaidari, Z.; Bornand, V.; Stöckli, R.; Trüssel, M.; Ackermann, Mathias; Favrot, Claude

doi:10.1016/j.vetmic.2009.01.002

Cited by 68 publications

(47 citation statements)

References 23 publications

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“…4). 2,6,19 FcaPV-3 is most closely related to genus Taupapillomavirus (TauPV) 10 and evidence from the present case suggests that this PV results in the presence of an angular shrunken nucleus that retains nuclear architecture. Elongated basophilic bodies were often within the cytoplasm adjacent to the nuclei.…”

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confidence: 61%

The detection of Felis catus papillomavirus 3 DNA in a feline bowenoid in situ carcinoma with novel histologic features and benign clinical behavior

2016

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Brief CommunicationPapillomaviruses (PVs) are highly species-specific epitheliotropic DNA viruses. As part of their normal replication, PVs produce oncoproteins that disrupt normal cell regulation. 1 The vast majority of PV infections either do not result in the development of a visible lesion or cause a self-resolving hyperplastic wart. 7 However, the oncogenes produced by a small number of PV types can predispose an infected cell to neoplastic transformation. 1Disease resulting from PV infection is considered uncommon in cats. 8 To date, the disease that is most strongly associated with PV infection in cats is bowenoid in situ carcinoma (BISC; papillomavirus-associated squamous cell carcinoma in situ). 9,13 This neoplasm typically occurs as single or multiple scaly or crusting lesions within haired skin, especially around the head and neck. 4 Cats with BISCs may require euthanasia either because of the development of multiple BISCs or because of progression of a BISC to a squamous cell carcinoma (SCC). Devon Rex, and the closely related Sphinx, cats may be predisposed to BISCs, and BISCs in cats of these breeds are often rapidly progressive. 15A 17-year-old female Domestic Shorthair cat was presented to the primary care veterinarian because of a slightly raised 0.5 cm in diameter interscapular skin mass of uncertain duration.No tests were performed at this time, and a post-injection inflammatory reaction was suspected because the cat had received multiple subcutaneous injections at this location for the management of previously diagnosed diabetes mellitus and chronic renal failure. The mass was reported to have enlarged slowly, and 18 months later had doubled in size to 1 cm in diameter. The cat had no other skin lesions. The mass was surgically removed with 1-cm margins and submitted for histologic examination.On histologic examination, normal epidermis merged abruptly with a well-demarcated focus of marked, irregular epidermal hyperplasia. There were multiple, broad, downward-projecting rete pegs confined by the basement membrane and accompanying mild parakeratosis, hyperkeratosis, and variable melanization. The epidermal hyperplasia also Abstract. Bowenoid in situ carcinoma (BISC; papillomavirus-associated squamous cell carcinoma in situ) is an uncommon skin neoplasm of cats that can result in euthanasia because of the development of multiple lesions or because of progression to invasive squamous cell carcinoma. BISCs are currently thought to be caused by Felis catus papillomavirus 2 (FcaPV-2). The presently described cat developed a single 0.5 cm in diameter interscapular mass. Over the following 18 months, the mass doubled in size; no additional lesions developed. The mass was surgically excised and histologically diagnosed as a BISC. However, in contrast to previously reported BISCs, neither prominent thickening of the deep aspects of the follicular infundibula nor marked cell dysplasia were present. Furthermore, ~50% of the keratinocytes in the affected epidermis had prominent PV cytopathic changes that...

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confidence: 61%

The detection of Felis catus papillomavirus 3 DNA in a feline bowenoid in situ carcinoma with novel histologic features and benign clinical behavior

2016

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“…11 This motif has been identified in FdPV-2. 18 Therefore, the significant association between the presence of PV DNA and reduced pRb suggests that FdPV-2 can bind to and degrade pRb. Within the PVs that infect nonhuman species, only the cottontail rabbit papillomavirus has been shown to degrade pRb.…”

Section: Discussionmentioning

confidence: 99%

Loss of Retinoblastoma Protein, But Not p53, Is Associated With the Presence of Papillomaviral DNA in Feline Viral Plaques, Bowenoid In Situ Carcinomas, and Squamous Cell Carcinomas

Munday

Aberdein

2011

Vet Pathol

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Although papillomaviral (PV) DNA is frequently present in feline cutaneous squamous cell carcinomas (SCCs), a causative association cannot be proven. Oncogenic human PVs cause neoplastic transformation by inhibiting retinoblastoma (pRb) and p53 activity. Therefore, absence of pRb and p53 immunostaining, along with increased p16 immunostaining, indicates a PV cause in some human SCCs. If PVs cause cutaneous feline SCCs, it was hypothesized that a similar immunohistochemistry profile, along with PV DNA, would be detectable. This was investigated using 5 feline viral plaques, 10 Bowenoid in situ carcinomas, 19 SCCs from ultraviolet-exposed (UV-exposed) skin, and 11 SCCs from UV-protected skin. Papillomaviral DNA was amplified by polymerase chain reaction from 30 of 45 lesions. Reduced pRb immunostaining was present in 26 of 45; increased p16 immunostaining was in 30; and p53 immunostaining was in 19. Both reduced pRb immunostaining and increased p16 immunostaining were more frequent in lesions containing PV DNA. In contrast, no association was observed between p53 immunostaining and the presence of PV DNA. SCCs from UV-protected skin more frequently contained PV DNA, reduced pRb, and increased p16 than UV-exposed SCCs. UV exposure was not associated with p53 immunostaining within the SCCs. These results suggest that feline PVs alter cell regulation by degrading pRb. Unlike oncogenic human PVs, there was no evidence that feline PVs degrade p53. These results provide further evidence that PVs may cause feline cutaneous SCCs, especially those in UV-protected skin, and they suggest a possible mechanism of this oncogenic action.

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“…The bovine papillomaviruses (BVPs) of the Deltapapillomavirus genus, however, have the ability to infect both epithe lial and mesenchymal cells of different species (Bernard et al, 2010;Joh et al, 2011;Munday et al, 2014). Lesions caused by PVs in domestic cats may be oral papillomas (Felis catus (Fca) PV1) , feline cu taneous viral plaques, Bowenoid carcinomas (FcaPV2 and FcaPV3) (Lange et al, 2009;Munday et al, 2013) and feline sarcoids. Feline sarcoids are spindeloid sarco mas of younger cats with close connection to the epi dermis, which are reported not to metastasize but often tend to develop recurrences after incomplete surgical was not possible because of the location next to the left nostril.…”

Section: Introductionmentioning

confidence: 99%

Feline sarcoid in a 1-year-old domestic short-haired cat caused by bovine papillomavirus type 14 in Switzerland

Kiefer¹,

Tobler²,

Ramsauer³

et al. 2017

SAT

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A 1-year-old domestic short haired cat, living on a farm in Switzerland, was presented to the veterinarian with a 5 cm in diameter mass, bulging from her left nostril. The mass was only incompletely removed because of its unfavourable location. Histologically, the lesion consisted of an infiltrative growing spindeloid proliferation in close approximation to the epidermis and was diagnosed as a feline sarcoid tumour. The presence of Bovine Papillomavirus type 14 (BPV-14) specific DNA could be identified in the tissue by using two PCR assays. The amplified sequences of 194 and 549 base pairs (bp) were 99% and 100% identical with a virus isolated after autopsy, from a cat with feline sarcoid in the USA. The cat recovered completely after an even incomplete surgical excision and no recurrence could be observed 10 months later. SummaryA 1year old domestic short haired cat, living on a farm in Switzerland, was presented to the veterinarian with a 5 cm in diameter mass, bulging from her left nostril. The mass was only incompletely removed because of its unfavourable location. Histologically, the lesion con sisted of an infiltrative growing spindeloid proliferation in close approximation to the epidermis and was diag nosed as a feline sarcoid tumour. The presence of Bovine Papillomavirus type 14 (BPV14) specific DNA could be identified in the tissue by using two PCR assays. The amplified sequences of 194 and 549 base pairs (bp) were 99% and 100% identical with a virus isolated after aut opsy, from a cat with feline sarcoid in the USA. The cat recovered completely after an even incomplete surgical excision and no recurrence could be observed 10 months later.

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Sequence and classification of FdPV2, a papillomavirus isolated from feline Bowenoid in situ carcinomas

Cited by 68 publications

References 23 publications

The detection of Felis catus papillomavirus 3 DNA in a feline bowenoid in situ carcinoma with novel histologic features and benign clinical behavior

The detection of Felis catus papillomavirus 3 DNA in a feline bowenoid in situ carcinoma with novel histologic features and benign clinical behavior

Loss of Retinoblastoma Protein, But Not p53, Is Associated With the Presence of Papillomaviral DNA in Feline Viral Plaques, Bowenoid In Situ Carcinomas, and Squamous Cell Carcinomas

Feline sarcoid in a 1-year-old domestic short-haired cat caused by bovine papillomavirus type 14 in Switzerland

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