Sequence-dependent conformational changes in DNA induced by polynuclear platinum complexes

McGregor, Tracey D.; Balcarová, Zdeňka; Qu, Yun; Tran, My-Chau; Žaludová, Renata; Brabec, Viktor; Farrell, Nicholas

doi:10.1016/s0162-0134(99)00136-1

Cited by 39 publications

(27 citation statements)

References 17 publications

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“…1) was shown to have unique DNA binding properties (19,83,84). The prototype, also called BBR3464, is active against melanoma, lung cancer, and pancreatic cancers and retains active in cisplatinresistant cell lines.…”

Section: New Types Of Drugsmentioning

confidence: 99%

New clues for platinum antitumor chemistry: Kinetically controlled metal binding to DNA

Reedijk

2003

Proc. Natl. Acad. Sci. U.S.A.

579

349

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Section: New Types Of Drugsmentioning

confidence: 99%

New clues for platinum antitumor chemistry: Kinetically controlled metal binding to DNA

Reedijk

2003

Proc. Natl. Acad. Sci. U.S.A.

579

349

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“…The overall changes in the CD spectra indicate the existence of B ! A CT DNA transition that can be attributed to intrastrand linking of adjacent guanines so that the DNA conformation is modified and destacking of the adjacent bases occurs [72][73][74]. Similar behavior is observed in the CD spectra of CT DNA in the presence of complexes Mn(pr-norf) 2 -(H 2 O) 2 , Co(pr-norf) 2 (H 2 O) 2 , Ni(pr-norf) 2 (H 2 O) 2 , Zn(prnorf) 2 (H 2 O) 2 and Cd(pr-norf) 2 (H 2 O) 2 .…”

Section: Study Of the Complexes-dna Interaction With CD Spectroscopymentioning

confidence: 99%

Metal complexes with the quinolone antibacterial agent N-propyl-norfloxacin: Synthesis, structure and bioactivity

Efthimiadou

Psomas

Sanakis

et al. 2007

Journal of Inorganic Biochemistry

104

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“…The effect of various metal-based compounds, especially antitumor platinum drugs, on the salt-induced BrZ transition in poly(dG-dC) or poly(dG-m 5 dC) has already been described in several papers [36,37,38,39]. For instance, cisplatin was found to facilitate the BrZ transition, but the resulting Z form was distorted and the transition cooperativity was considerably reduced [40,41].…”

Section: Brz Transitionmentioning

confidence: 99%

Biophysical analysis of natural, double-helical DNA modified by anticancer heterocyclic complexes of ruthenium(III) in cell-free media

Malina

Nováková

Keppler

et al. 2001

J. Biol. Inorg. Chem.

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Modifications of natural DNA by three anticancer heterocyclic ruthenium(III) compounds were studied by methods of molecular biophysics. These methods included DNA binding studies using atomic absorption spectrophotometry, inhibition of restriction endonucleases, mapping of DNA adducts by transcription assay, interstrand cross-linking employing gel electrophoresis under denaturing conditions, DNA unwinding studied by gel electrophoresis, circular dichroism analysis of the B-->Z transition in DNA, and DNA melting curves measured by absorption spectrophotometry. The results indicate that the complexes HIm[trans-Cl4Im2RuIII], HInd[trans-Cl4Ind2RuIII], and Na[trans-Cl4Im(Me2SO)RuIII] (Im and Ind stand for imidazole and indazole, respectively) coordinate irreversibly to DNA. Their DNA binding mode is, however, different from that of cisplatin. Interestingly, Na[trans-Cl4Im(Me2SO)RuIII] binds to DNA considerably faster than the other two ruthenium compounds and cisplatin. In addition, when Na[trans-Cl4Im(Me2SO)RuIII] binds to DNA it exhibits an enhanced base sequence specificity in comparison with the other two ruthenium complexes. Na[trans-Cl4Im(Me2SO)RuIII] also forms bifunctional intrastrand adducts on double-helical DNA which are capable of terminating RNA synthesis in vitro, while the capability of the other two ruthenium compounds to form such adducts is markedly lower. This observation has been interpreted to mean that the bifunctional adducts of HInd[trans-Cl4Ind2RuIII] and Na[trans-Cl4Im2RuIII] formed on rigid double-helical DNA are sterically more crowded by their octahedral geometry than those of Na[trans-Cl4Im(Me2SO)RuIII]. In addition, the adducts of all three ruthenium compounds affect the conformation of DNA, Na[trans-Cl4Im(Me2SO)RuIII] being most effective. It has been suggested that the altered DNA binding mode of ruthenium compounds in comparison with cisplatin might be an important factor responsible for the altered cytostatic activity of this class of ruthenium compounds in tumor cells.

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Sequence-dependent conformational changes in DNA induced by polynuclear platinum complexes

Cited by 39 publications

References 17 publications

New clues for platinum antitumor chemistry: Kinetically controlled metal binding to DNA

New clues for platinum antitumor chemistry: Kinetically controlled metal binding to DNA

Metal complexes with the quinolone antibacterial agent N-propyl-norfloxacin: Synthesis, structure and bioactivity

Biophysical analysis of natural, double-helical DNA modified by anticancer heterocyclic complexes of ruthenium(III) in cell-free media

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