Sequence variation in the Newcastle disease virus genome

Kattenbelt, J. A.; Stevens, Matthew P.; Gould, Allan R.

doi:10.1016/j.virusres.2005.10.001

Cited by 96 publications

(78 citation statements)

References 28 publications

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“…Virulent isolates from outbreaks in Australia were shown to be genetically similar to the viruses of low virulence that were known to be previously circulating in the country (Kattenbelt et al, 2006). These endemic low virulence viruses require only two point mutations to become virulent (Westbury, 2001).…”

Section: Advances In Animal and Veterinary Sciences June 2015 | Volummentioning

confidence: 95%

Virulence of Newcastle Disease Virus and Diagnostic Challenges

Bulbule¹

2015

Adv. Anim. Vet. Sci.

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Section: Advances In Animal and Veterinary Sciences June 2015 | Volummentioning

confidence: 95%

Virulence of Newcastle Disease Virus and Diagnostic Challenges

Bulbule¹

2015

Adv. Anim. Vet. Sci.

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“…Viral genome is non-segmented, formed by a single stranded RNA with negative polarity (-ss RNA), coding for six proteins: NP -nucleoprotein, M -matrix protein, F -fusion protein, HN -haemagglutinin-neuraminidase protein, P -phosphorylated nucleocapsideassociated protein and L-RNA-dependent RNA polymerase (Kattenbelt et al 2006). The virulence of the NDV is closely related to the variable cleavability of the F protein due to distinct amino acid composition of the "cleavage site" (L e e et al 2004;de Leeuw et al 2005).…”

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confidence: 99%

Detection of the Newcastle disease virus and its effect on development of post-vaccination immunity in a commercial flock of laying hens

et al. 2012

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The aim of this study was to monitor the concentration of antibodies against Newcastle disease after vaccination of laying hens at the beginning and in the end of the laying period. The study was carried out in one commercial flock of laying hens in Opatovice in the Czech Republic in the years 2008-2010. A total of 280 samples of blood sera were taken from laying hens coming from four poultry houses. The sera were tested by the haemagglutination inhibition test according to the OIE Manual. Virological testing was conducted as a consequence of atypical results of serological testing. Newcastle disease virus RNA was proved by the RT-nested PCR method in the pooled tissue samples of 5 hens, in the samples of intestines with ileocaecal tonsila, in trachea and also in one swab sample from the environment of one house. Based on sequencing analysis and subsequent phylogenetic analysis, the virus was identified as a low pathogenic strain of paramyxovirus (PMV-1). This low pathogenic strain did not have any impact on the health of laying hens.

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“…Most of the reports had not only looked into the biological characteristics of the virus but also sequenced the FPCS to determine the virulence of the virus [21,22,24,42]. There are also reports on isolation, biological characterization and FPCS sequence based pathotyping of NDV from backyard chicken [6] and other species of birds such as pigeons [18,24,40,42,46] Japanese quail [21], Turkey [37], Duck [47], crow [31], Emu [23] and Ostrich [45]. In fact there is also an isolation of a lentogenic strain of NDV from backyard chicken that has been completely characterised with respect to its biological and sequence (both the fusion (F) and Haemagglutinin neuraminidase (HN) genes) characteristics [6,32,34,43] and the same has been used in preparing an oral pellet vaccine.…”

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confidence: 99%

Analysis of the Fusion Protein Cleavage Site of Newcastle disease virus Isolates from India Reveals Preliminary Evidence for the Existence of II, VI and VII Genotypes

et al. 2011

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Newcastle disease virus (NDV) has been a threat to poultry industry in most of the developing countries with a wide variety of avian species being susceptible, coupled with the presence of mobile wild bird reservoirs contributing not only to the vast genomic diversity of this virus but also to the diagnostic failures. NDV of multiple genotypes (I-XI) is known to be prevalent and reported worldwide. However, there is a paucity of information on the circulating genotypes of NDV in India. This study utilized the fusion protein cleavage site (FPCS) sequence to determine the different genotypes of NDV circulating in India. Our results indicate that majority of NDV isolates from southern states of India namely, Tamil Nadu, Kerala and Karnataka were found to belong to genotype II. However, some of the strains from Tamil Nadu and most from Uttar Pradesh belong to genotype groups VI and VII. Interestingly, three isolates recovered from Tamil Nadu grouped with genotype IV viruses (namely Herts/33) which had not been hitherto reported to GenBank since 1989. This preliminary information points to the existence of multiple genotypes and also the need for efficacy studies with vaccines incorporating multiple genotypes in controlling virulent NDV (vNDV) outbreaks in India.

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Sequence variation in the Newcastle disease virus genome

Cited by 96 publications

References 28 publications

Virulence of Newcastle Disease Virus and Diagnostic Challenges

Virulence of Newcastle Disease Virus and Diagnostic Challenges

Detection of the Newcastle disease virus and its effect on development of post-vaccination immunity in a commercial flock of laying hens

Analysis of the Fusion Protein Cleavage Site of Newcastle disease virus Isolates from India Reveals Preliminary Evidence for the Existence of II, VI and VII Genotypes

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