Sequential changes in hematologic and biochemical parameters in African tick bite fever

Jensenius, Mogens; Fournier, Pierre‐Edouard; Hellum, Kjell B.; Wesslén, Lars; Caruso, Giuseppe; Priø, Tine Krogstrup; Løhne, Kari; Vene, Sirkka; Raoult, Didier; Myrvang, Bjørn

doi:10.1046/j.1469-0691.2003.00713.x

Cited by 19 publications

(7 citation statements)

References 19 publications

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“…Few specific clinical signs exist in rickettsial diseases. Many cases have a nonfocal febrile disease of mild-to-moderate severity, accompanied by nonspecific results in routine blood tests ( 32 ). The inoculation eschar, a painless black skin lesion surrounded by a red halo that develops at the site of the infective tick or mite bite, is a useful diagnostic clue in SFG rickettsioses and scrub typhus, but may be absent in < 40% of such cases ( 14 ).…”

Section: Discussionmentioning

confidence: 99%

Multicenter GeoSentinel Analysis of Rickettsial Diseases in International Travelers, 1996–2008

Jensenius

Davis²,

Sonnenburg

et al. 2009

Emerg. Infect. Dis.

143

114

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Section: Discussionmentioning

confidence: 99%

Multicenter GeoSentinel Analysis of Rickettsial Diseases in International Travelers, 1996–2008

Jensenius

Davis²,

Sonnenburg

et al. 2009

Emerg. Infect. Dis.

143

114

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“…However, these major clinical signs vary with the rickettsial species involved (Table 1). Non‐specific haematological and biochemical findings include thrombocytopenia, leukocyte count abnormalities and elevated hepatic enzyme levels [15,16]. Further studies of atypical cases have also led to the description of new clinical syndromes caused by organisms previously considered as ‘rickettsiae of unknown pathogenicity’, including R. slovaca and R. helvetica [8,9,17].…”

Section: Clinical and Standard Laboratory Featuresmentioning

confidence: 99%

Guidelines for the diagnosis of tick-borne bacterial diseases in Europe

Brouqui¹,

Bacellar²,

Baranton³

et al. 2004

Clinical Microbiology and Infection

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361

281

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Ticks are obligate haematophagous acarines that parasitise every class of vertebrate (including man) and have a worldwide distribution. An increasing awareness of tick-borne diseases among clinicians and scientific researchers has led to the recent description of a number of emerging tick-borne bacterial diseases. Since the identification of Borrelia burgdorferi as the agent of Lyme disease in 1982, 11 tick-borne human bacterial pathogens have been described in Europe. Aetiological diagnosis of tick-transmitted diseases is often difficult and relies on specialised laboratories using very specific tools. Interpretation of laboratory data is very important in order to establish the diagnosis. These guidelines aim to help clinicians and microbiologists in diagnosing infection transmitted by tick bites and to provide the scientific and medical community with a better understanding of these infectious diseases.

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“…3 Basic laboratory findings of elevated C-reactive protein levels and lymphopenia are the most commonly found abnormalities in ATBF, with 94.5% of patients having one or both derangements. 9 Thrombocytopenia and elevation of aspartate aminotransferase and alanine aminotransfer levels can also occur, whereas abnormalities in bilirubin, hemoglobin, sodium, and creatinine are usually not present. 9 These factors can help differentiate ATBF from the more sinister rickettsial infections.…”

Section: Discussionmentioning

confidence: 99%

“…9 Thrombocytopenia and elevation of aspartate aminotransferase and alanine aminotransfer levels can also occur, whereas abnormalities in bilirubin, hemoglobin, sodium, and creatinine are usually not present. 9 These factors can help differentiate ATBF from the more sinister rickettsial infections. Although there are specific PCR tests for ATBF, the availability of these tests is limited.…”

Section: Discussionmentioning

confidence: 99%

31-Year-Old South African Man With Fever and Headache

Johnson

Schupack

Virk

2019

Mayo Clinic Proceedings

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A 31-year-old man with no medical history presented to the emergency department (ED) with a 1-week history of worsening headaches, myalgia, and high-grade fever. He had arrived in Minnesota from South Africa a few days before onset of symptoms to work on a local farm. In South Africa, he worked near Durban as a farmer tending sheep and cattle in open fields. He complained of diffuse body aches, mild headache, chills, and subjective fevers. He sought an evaluation at a local urgent care center 2 days after the onset of symptoms, where basic blood work was notable only for an elevated C-reactive protein level at 65.3 mg/L (reference range, <5.0 mg/L). He was given a course of amoxicillin and a tetanus shot. The patient was not taking any other daily medications. A blood smear was negative for malaria. While taking the antibiotics, his symptoms progressed with worsening headache and photophobia. He reported having multiple previous tick and mosquito bites, as well as animal exposures because of his work on the farm. Before leaving South Africa, he had felt well and had no known sick contacts. He was married and reported no recent new sexual contacts. He was unsure of his immunization status.He presented to the ED on day 7 of the current illness because of worsening symptoms. He underwent computed tomography of the head, lumbar puncture, and basic laboratory work-up and was initiated on treatment for meningitis before being admitted to the hospital.

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Sequential changes in hematologic and biochemical parameters in African tick bite fever

Abstract: The sequential changes in many biological parameters during the acute phase of ATBF mimic those reported in other SFG rickettsioses. Mild abnormalities are frequent, with increased S-CRP and lymphopenia being the two most consistent findings.

Cited by 19 publications

References 19 publications

Multicenter GeoSentinel Analysis of Rickettsial Diseases in International Travelers, 1996–2008

Multicenter GeoSentinel Analysis of Rickettsial Diseases in International Travelers, 1996–2008

Guidelines for the diagnosis of tick-borne bacterial diseases in Europe

31-Year-Old South African Man With Fever and Headache

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