Sequential delivery of chlorhexidine acetate and bFGF from PLGA-glycol chitosan core-shell microspheres

Chen, Ming-Mao; Cao, Huấn; Liu, Yuan-Yuan; Liu, Yan; Song, Feifei; Chen, Jingdi; Zhang, Qiqing; Yang, Wenzhi

doi:10.1016/j.colsurfb.2016.05.045

Cited by 34 publications

(16 citation statements)

References 30 publications

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“…These polymers containing ester bonds are biodegradable, and the biodegradation rate can be controlled by changing the degree of crystallinity or block copolymerization [11,12,13,14]. Nevertheless, the primary drawback is that the acidic degradation products may cause tissue inflammation in the degradation process [15,16,17]. Furthermore, the innate hydrophobicity of these macromolecules leads to a decrease in surface wettability, which is unfavorable for maintaining original molecular conformation and bioactivity of loaded drugs [13,18,19].…”

Section: Introductionmentioning

confidence: 99%

Porous Silk Fibroin Microspheres Sustainably Releasing Bioactive Basic Fibroblast Growth Factor

Wang

Niu

et al. 2018

Materials

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Basic fibroblast growth factor (bFGF) plays a significant role in stimulating cell proliferation. It remains a challenge in the field of biomaterials to develop a carrier with the capacity of continuously releasing bioactive bFGF. In this study, porous bFGF-loaded silk fibroin (SF) microspheres, with inside-out channels, were fabricated by high-voltage electrostatic differentiation, and followed by lyophilization. The embedded bFGF exhibited a slow release mode for over 13 days without suffering burst release. SEM observations showed that incubated L929 cells could fully spread and produce collagen-like fibrous matrix on the surface of SF microspheres. CLSM observations and the results of cell viability assay indicated that bFGF-loaded microspheres could significantly promote cell proliferation during five to nine days of culture, compared to bFGF-unloaded microspheres. This reveals that the bFGF released from SF microspheres retained obvious bioactivity to stimulate cell growth. Such microspheres sustainably releasing bioactive bFGF might be applied to massive cell culture and tissue engineering as a matrix directly, or after being combined with three-dimensional scaffolds.

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Section: Introductionmentioning

confidence: 99%

Porous Silk Fibroin Microspheres Sustainably Releasing Bioactive Basic Fibroblast Growth Factor

Wang

Niu

et al. 2018

Materials

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“…Positively charged GC allowed easier interaction between microspheres and negatively charged cell membranes by ionic adsorption. These microspheres were proved to be biocompatible with 3T3 fibroblast cells in vitro [37]. Chitosan shell on PLGA microparticles controlled the burst release as well as acidic degradation.…”

Section: Drug Deliverymentioning

confidence: 96%

PLGA Core-Shell Nano/Microparticle Delivery System for Biomedical Application

Patel

2021

Polymers

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Core–shell particles are very well known for their unique features. Their distinctive inner core and outer shell structure allowed promising biomedical applications at both nanometer and micrometer scales. The primary role of core–shell particles is to deliver the loaded drugs as they are capable of sequence-controlled release and provide protection of drugs. Among other biomedical polymers, poly (lactic-co-glycolic acid) (PLGA), a food and drug administration (FDA)-approved polymer, has been recognized for the vehicle material. This review introduces PLGA core–shell nano/microparticles and summarizes various drug-delivery systems based on these particles for cancer therapy and tissue regeneration. Tissue regeneration mainly includes bone, cartilage, and periodontal regeneration.

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“…The anionic materials commonly used to form complexes with chitosan include alginate [ 50 , 51 ], collagen [ 52 , 53 ], gelatin [ 9 , 54 , 55 , 56 ], poly(γ-glutamic acid) [ 57 ], β-glycerophosphate [ 58 , 59 , 60 ], and tripolyphosphate [ 47 , 61 ]. Chitosan can associate with synthetic polymers (poly(vinyl alcohol) [ 56 , 62 ], polyethylene glycol [ 63 ], and poly(lactic- co -glycolic acid) [ 64 ]) and other materials (including clays [ 65 ] and graphene oxide [ 52 ]) for producing DDSs with enhanced mechanical properties and hydrophilic–hydrophobic balance.…”

Section: Principal Polysaccharides Used For Biomedical Materialsmentioning

confidence: 99%

Polysaccharide-Based Materials Created by Physical Processes: From Preparation to Biomedical Applications

et al. 2021

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Polysaccharide-based materials created by physical processes have received considerable attention for biomedical applications. These structures are often made by associating charged polyelectrolytes in aqueous solutions, avoiding toxic chemistries (crosslinking agents). We review the principal polysaccharides (glycosaminoglycans, marine polysaccharides, and derivatives) containing ionizable groups in their structures and cellulose (neutral polysaccharide). Physical materials with high stability in aqueous media can be developed depending on the selected strategy. We review strategies, including coacervation, ionotropic gelation, electrospinning, layer-by-layer coating, gelation of polymer blends, solvent evaporation, and freezing–thawing methods, that create polysaccharide-based assemblies via in situ (one-step) methods for biomedical applications. We focus on materials used for growth factor (GFs) delivery, scaffolds, antimicrobial coatings, and wound dressings.

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Sequential delivery of chlorhexidine acetate and bFGF from PLGA-glycol chitosan core-shell microspheres

Cited by 34 publications

References 30 publications

Porous Silk Fibroin Microspheres Sustainably Releasing Bioactive Basic Fibroblast Growth Factor

Porous Silk Fibroin Microspheres Sustainably Releasing Bioactive Basic Fibroblast Growth Factor

PLGA Core-Shell Nano/Microparticle Delivery System for Biomedical Application

Polysaccharide-Based Materials Created by Physical Processes: From Preparation to Biomedical Applications

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