Sequential delivery of long‐pulsed 755‐nm alexandrite laser and long‐pulsed 1,064‐nm neodymium:yttrium‐aluminum‐garnet laser treatment for pigmented disorders

Abstract

Background Long‐pulsed (LP) lasers at pulse durations of 1‐300 ms have been used to destroy nests of nevi cells by selectively targeting pigment chromophores. Objective To evaluate dual‐wavelength LP laser‐induced tissue reactions. Methods The patterns of LP 755‐nm alexandrite (Alex) and/or 1064‐nm neodymium (Nd):yttrium‐aluminum‐garnet (YAG) laser‐induced tissue reactions were macroscopically evaluated using a tattoo‐embedded phantom. Additionally, a pilot in vivo human study was performed for common acquired melanocytic nevus, of which dermoscopic images and high‐speed cinematographs were obtained. Results Combinations of Nd:YAG and Alex laser treatments at interpulse intervals of 10 or 20 ms generated round to oval zones of photothermal and photoacoustic injury in two distinctive areas containing disintegrated tattoo particles. Treatment at interpulse intervals of 10 or 20 ms between Alex and Nd:YAG pulses elicited lesser degrees of thermal damage to surrounding tissues, compared to treatment at 100 or 200 ms. Immediately after combined LP laser treatment of human nevus lesions in vivo, Nd:YAG‐Alex treatment at a 20‐ms interpulse interval exhibited more remarkable crusting and erosive appearances than Alex‐Nd:YAG treatment. Conclusion For treating pigmented disorders, sequential delivery of LP Nd:YAG and Alex pulses at short interpulse intervals of 10‐20 ms can effectively destroy nests of pigment chromophores.

The dual 980‐nm and 1470‐nm diode laser for vascular lesions

“…Dual laser systems combine various wavelengths. [6][7][8] We present the very first data on a diode laser system with 980-nm and 1470-nm wavelength in dermatology. The 980-nm laser wavelength is primarily absorbed by hemoglobin.…”

“…Dual laser systems combine various wavelengths 6‐8 . We present the very first data on a diode laser system with 980‐nm and 1470‐nm wavelength in dermatology.…”

“…Dual lasers are a relatively new technology. They combine different wavelengths for optimal results 6‐8 . Here, we present the first experience with a new dual diode laser combining 980 nm with 1470 nm for vascular lesions.…”

Anti-melanogenesis Effect of a Dual-delivery Long-pulsed 1,064-nm Neodymium-doped Yttrium Aluminum Garnet and 755-nm Alexandrite Laser on Human Skin Explants

“…Long-pulsed (LP) lasers can be applied for pigmentary disorders, with high efficacy and a low risk of side effects, along with a short procedure time 1 2 . Recently, a dual-wavelength LP laser system was introduced 1 .…”

“…Long-pulsed (LP) lasers can be applied for pigmentary disorders, with high efficacy and a low risk of side effects, along with a short procedure time 1 2 . Recently, a dual-wavelength LP laser system was introduced 1 . This system seems to be theoretically more effective because it allows targeting of chromophores elaborately.…”